Interfacial Cholesterol Binding Sites on Potassium Channels
Potassium Channels
[EC and IC, extracellular and intracelluar interfaces, respectively; Chl gives the letter assigned to cholesterol molecules in the PDB files; Units of E, kcals/mol with molar concentration units]
| PDB | Chl | E | Local Residues |
| Bacterial Potassium Channels | |||
| KcsA | |||
| KcsA, plus K+, Streptomyces lividans, 1k4c | |||
| 1k4c_EC | A | -12.6 | Thr33.F, Leu36.F, Val37.F, Leu40.F, Leu66.F, Trp67.F, Val70.F, Val106.F, Leu86.I, Cys90.I, Val93.I, Val97.I |
| B | -12.6 | Leu86.F, Cys90.F, Val93.F, Val97.F, Thr33.L, Leu36.L, Val37.L, Leu40.L, Leu66.L, Trp67.L, Val70.L, Val106.L | |
| D | -12.6 | Thr33.C, Leu36.C, Val37.C, Leu40.C, Leu66.C, Trp67.C, Val70.C, Val106.C, Leu86.L, Cys90.L, Val93.L, Val97.L | |
| E | -12.6 | Leu86.C, Cys90.C, Val93.C, Val97.C, Thr33.I, Leu36.I, Val37.I, Leu40.I, Leu66.I, Trp67.I, Val70.I, Val106.I | |
| G | -12.5 | Leu86.C, Arg89.C, Cys90.C, Val93.C, Thr33.I, Val34.I, Val37.I, Leu40.I, Leu66.I, Trp67.I, Val70.I | |
| H | -12.5 | Thr33.C, Val34.C, Val37.C, Leu40.C, Leu66.C, Trp67.C, Val70.C, Leu86.L, Arg89.L, Cys90.L, Val93.L | |
| J | -12.5 | Thr33.F, Val34.F, Val37.F, Leu40.F, Leu66.F, Trp67.F, Val70.F, Leu86.I, Arg89.I, Cys90.I, Val93.I | |
| K | -12.4 | Leu86.F, Arg89.F, Cys90.F, Val93.F, Thr33.L, Val34.L, Val37.L, Leu40.L, Leu66.L, Trp67.L, Val70.L | |
| 1k4c_IC | A | -13.0 | Val97.F, Thr101.F, Trp26.L, Ala29.L, Thr33.L, Leu36.L, Val37.L, Phe103.L, Val106.L, Leu110.L |
| B | -13.0 | Trp26.F, Ala29.F, Thr33.F, Leu36.F, Val37.F, Phe103.F, Val106.F, Leu110.F, Val97.I | |
| D | -13.0 | Trp26.C, Ala29.C, Thr33.C, Leu36.C, Val37.C, Phe103.C, Val106.C, Leu110.C, Val97.L | |
| E | -13.0 | Val97.C, Trp26.I, Ala29.I, Thr33.I, Leu36.I, Val37.I, Phe103.I, Val106.I, Leu110.I | |
| KcsA, open mutant, Streptomyces lividans, 5vk6 | |||
| 5vk6_EC | A | -14.4 | Thr33.C, Val37.C, Pro63.C, Arg64.C, Leu66.C, Trp67.C, Val70.C, Leu86.I, Arg89.I, Cys90.I, Val93.I |
| B | -14.4 | Leu86.C, Arg89.C, Cys90.C, Val93.C, Thr33.L, Val37.L, Pro63.L, Arg64.L, Leu66.L, Trp67.L, Val70.L | |
| D | -13.6 | Leu86.F, Arg89.F, Cys90.F, Val93.F, Pro63.I, Arg64.I, Leu66.I, Trp67.I, Val70.I | |
| E | -13.5 | Pro63.F, Arg64.F, Leu66.F, Trp67.F, Val70.F, Leu86.L, Arg89.L, Cys90.L, Val93.L | |
| 5vk6_IC | A | -14.1 | Trp26.C, Ala29.C, Gly30.C, Thr33.C, Val106.C, Leu110.C, Trp87.I, Cys90.I, Val94.I, Val97.I |
| B | -13.5 | Trp87.C, Cys90.C, Val94.C, Val97.C, Trp26.L, Arg27.L, Ala29.L, Gly30.L, Thr33.L | |
| D | -13.4 | Trp26.F, Arg27.F, Ala29.F, Gly30.F, Thr33.F, Trp87.L, Cys90.L, Val94.L, Val97.L | |
| E | -13.4 | Trp87.F, Cys90.F, Val94.F, Val97.F, Trp26.I, Arg27.I, Ala29.I, Gly30.I, Thr33.I | |
| Inward-rectifier Kir channels | |||
| Kir2.2 | |||
| Kir2.2, chicken, 3jyc | |||
| 3jyc_EC | E | -12.7 | Pro156.B, Val159.B, Phe160.B, Val163.B, Ile167.B, Ser87.D, Leu91.D, Val131.D, Phe134.D |
| F | -12.7 | Ser87.A, Leu91.A, Val131.A, Phe134.A, Pro156.D, Val159.D, Phe160.D, Val163.D, Ile167.D | |
| G | -12.7 | Pro156.A, Val159.A, Phe160.A, Val163.A, Ile167.A, Ser87.C, Leu91.C, Val131.C, Phe134.C | |
| H | -12.7 | Ser87.B, Leu91.B, Val131.B, Phe134.B, Pro156.C, Val159.C, Phe160.C, Val163.C, Ile167.C | |
| 3jyc_IC | E | -13.7 | Arg80.B, Leu83.B, Leu157.C, Phe160.C, Met161.C, Val164.C, Val168.C, Ile171.C |
| F | -13.6 | Arg80.A, Leu83.A, Leu157.D, Phe160.D, Met161.D, Val164.D, Val168.D, Ile171.D | |
| G | -13.4 | Ile100.A, Phe160.A, Met161.A, Val164.A, Val168.A, Ile171.A, Phe175.A, Arg80.C, Leu83.C | |
| H | -13.3 | Ile100.B, Phe160.B, Met161.B, Val164.B, Val168.B, Ile171.B, Phe175.B, Arg80.D, Leu83.D | |
| Kir2.2, complex with PPA, chicken, 3spc | |||
| 3spc_EC | E | -13.4 | Pro156.B, Val159.B, Phe160.B, Val163.B, Val164.B, Ile167.B, Ser87.C, Leu91.C, Val131.C, Phe134.C |
| F | -13.4 | Ser87.A, Leu91.A, Val131.A, Phe134.A, Pro156.C, Val159.C, Phe160.C, Val163.C, Val164.C, Ile167.C | |
| G | -13.4 | Pro156.A, Val159.A, Phe160.A, Val163.A, Val164.A, Ile167.A, Ser87.D, Leu91.D, Val131.D, Phe134.D | |
| H | -13.4 | Ser87.B, Leu91.B, Val131.B, Phe134.B, Pro156.D, Val159.D, Phe160.D, Val163.D, Val164.D, Ile167.D | |
| 3spc_IC | [none] | ||
| Kir2.2, mutant in complex with PIP2, chicken, 3spg | |||
| 3spg_EC | [none] | ||
| 3spg_IC | [none] | ||
| Kir2.2, mutant in complex witn PIP2, chicken, 3sph | |||
| 3sph_EC | E | -12.5 | Glu153.B, Pro156.B, Val159.B, Phe160.B, Val163.B, Leu91.C, Val131.C, Phe134.C |
| F | -12.5 | Glu153.A, Pro156.A, Val159.A, Phe160.A, Val163.A, Leu91.D, Val131.D, Phe134.D | |
| G | -12.5 | Leu91.B, Val131.B, Phe134.B, Glu153.D, Pro156.D, Val159.D, Phe160.D, Val163.D | |
| H | -12.5 | Leu91.A, Val131.A, Phe134.A, Glu153.C, Pro156.C, Val159.C, Phe160.C, Val163.C | |
| 3sph_IC | [none] | ||
| Kir2.2, in complex with PIP2, chicken, 3spi | |||
| 3spi_EC | E | -13.1 | Leu91.B, Val131.B, Phe134.B, Pro156.D, Val159.D, Phe160.D, Val163.D, Ile167.D |
| F | -13.1 | Pro156.B, Val159.B, Phe160.B, Val163.B, Ile167.B, Leu91.C, Val131.C, Phe134.C | |
| G | -12.6 | Glu153.A, Pro156.A, Val159.A, Phe160.A, Val163.A, Ile167.A, Leu91.D, Val131.D, Phe134.D | |
| H | -12.4 | Leu91.A, Val131.A, Phe134.A, Glu153.C, Pro156.C, Val159.C, Phe160.C, Val163.C, Ile167.C | |
| 3spi_IC | [none] | ||
| Kir2.2, mutant apo form, chicken 3spj | |||
| 3spj_EC | E | -13.1 | Leu91.B, Val131.B, Phe134.B, Pro156.D, Val159.D, Phe160.D, Val163.D, Ile167.D |
| F | -13.1 | Pro156.B, Val159.B, Phe160.B, Val163.B, Ile167.B, Leu91.C, Val131.C, Phe134.C | |
| G | -12.6 | Glu153.A, Pro156.A, Val159.A, Phe160.A, Val163.A, Ile167.A, Leu91.D, Val131.D, Phe134.D | |
| H | -12.4 | Leu91.A, Val131.A, Phe134.A, Glu153.C, Pro156.C, Val159.C, Phe160.C, Val163.C, Ile167.C | |
| 3spj_IC | [none] | ||
| Kir2.2, K62W mutant, apo form, chicken, 5kum | |||
| 5kum_EC | [none] | ||
| 5kum_IC | [none] | ||
| Kir2.2, open mutant complex with PIP2, chicken, 6m84 | |||
| 6m84_EC | [none] | ||
| 6m84_IC | E | -13.3 | Phe160.A, Val163.A, Val164.A, Trp79.C, Arg80.C, Tyr81.C, Leu83.C, Leu84.C, Ser87.C, Leu91.C, Phe134.C |
| F | -13.3 | Arg80.A, Leu83.A, Leu84.A, Ser87.A, Leu91.A, Phe134.A, Phe160.D, Val163.D, Val164.D | |
| G | -13.2 | Phe160.B, Val163.B, Val164.B, Trp79.D, Arg80.D, Tyr81.D, Leu83.D, Leu84.D, Ser87.D, Leu91.D, Phe134.D | |
| Kir2.2, apo channel in different salt condition, chicken, 6m85 | |||
| 6m85_EC | E | -13.1 | Pro156.A, Val159.A, Phe160.A, Val163.A, Ile167.A, Ser87.D, Leu91.D, Val131.D, Phe134.D |
| F | -13.1 | Pro156.B, Val159.B, Phe160.B, Val163.B, Ile167.B, Ser87.C, Leu91.C, Val131.C, Phe134.C | |
| G | -13.1 | Ser87.B, Leu91.B, Val131.B, Phe134.B, Pro156.D, Val159.D, Phe160.D, Val163.D, Ile167.D | |
| H | -13.1 | Ser87.A, Leu91.A, Val131.A, Phe134.A, Pro156.C, Val159.C, Phe160.C, Val163.C, Ile167.C | |
| 6m85_IC | [none] | ||
| Kir2.2, open mutant, chicken, 6m86 | |||
| 6m86_EC | [none] | ||
| 6m86_IC | [none] | ||
| Kir3.2 | |||
| Kir3.2, GIRK2, complex with PIP2, mouse, 3sya | |||
| 3sya_EC | E | -11.7 | Met100.A, Thr103.A, Val104.A, Leu107.A, Val142.A, Phe145.A, Asp164.C, Pro167.C, Ile170.C, Ile171.C |
| F | -11.5 | Asp164.B, Pro167.B, Ile170.B, Ile171.B, Met100.C, Thr103.C, Val104.C, Leu107.C, Val142.C, Phe145.C | |
| G | -11.5 | Asp164.A, Pro167.A, Ile170.A, Ile171.A, Met100.D, Thr103.D, Val104.D, Leu107.D, Val142.D, Phe145.D | |
| H | -11.5 | Met100.B, Thr103.B, Val104.B, Leu107.B, Val142.B, Phe145.B, Pro167.D, Ile170.D, Ile171.D | |
| 3sya_IC | F | -13.2 | Leu95.A, Leu79.C, Thr80.C, Ile82.C, Phe108.C, Phe109.C, Ile175.C, Leu179.C |
| G | -13.1 | Leu79.B, Thr80.B, Asp81.B, Ile82.B, Phe108.B, Phe109.B, Ile175.B, Leu179.B, Leu95.C | |
| H | -12.9 | Leu79.A, Thr80.A, Ile82.A, Phe108.A, Phe109.A, Ile175.A, Leu179.A, Leu95.D | |
| I | -12.9 | Leu95.B, Leu79.D, Thr80.D, Ile82.D, Phe108.D, Phe109.D, Ile175.D, Leu179.D | |
| Kir3.2, GIRK2, D228N mutant, mouse, 3syc | |||
| 3syc_EC | E | -12.1 | Cys166.B, Pro167.B, Ile170.B, Ile171.B, Leu174.B, Met100.C, Val104.C, Leu107.C, Phe141.C, Val142.C, Phe145.C |
| F | -12.1 | Cys166.A, Pro167.A, Ile170.A, Ile171.A, Leu174.A, Met100.D, Val104.D, Leu107.D, Phe141.D, Val142.D, Phe145.D | |
| G | -12.1 | Met100.A, Val104.A, Leu107.A, Phe141.A, Val142.A, Cys166.C, Pro167.C, Ile170.C, Ile171.C, Leu174.C | |
| H | -12.1 | Met100.B, Val104.B, Leu107.B, Phe141.B, Val142.B, Phe145.B, Cys166.D, Pro167.D, Ile170.D, Ile171.D, Leu174.D | |
| 3syc_IC | E | -15.7 | Ile82.D, Thr85.D, Leu86.D, Leu89.D, Phe93.D, Ile97.D, Val101.D, Val104.D, Phe108.D |
| F | -15.7 | Ile82.A, Thr85.A, Leu86.A, Leu89.A, Phe93.A, Ile97.A, Val101.A, Val104.A, Phe108.A | |
| G | -15.6 | Ile82.C, Thr85.C, Leu86.C, Leu89.C, Phe93.C, Ile97.C, Met100.C, Val101.C, Val104.C, Leu107.C | |
| H | -14.6 | Trp91.B, Leu95.B, Ile195.B, Lys200.B, Ile82.D, Phe83.D, Phe108.D, Phe109.D, Ile175.D, Leu179.D, Phe186.D | |
| I | -14.6 | Ile82.A, Phe83.A, Phe108.A, Phe109.A, Ile175.A, Leu179.A, Phe186.A, Trp91.D, Leu95.D, Ile195.D, Lys200.D | |
| J | -14.6 | Ile82.B, Phe83.B, Phe108.B, Phe109.B, Ile175.B, Leu179.B, Phe186.B, Trp91.C, Leu95.C, Ile195.C, Lys200.C | |
| K | -14.6 | Trp91.A, Leu95.A, Ile195.A, Lys200.A, Ile82.C, Phe83.C, Phe108.C, Phe109.C, Ile175.C, Leu179.C, Phe186.C | |
| L | -14.4 | Ile82.B, Thr85.B, Leu86.B, Leu89.B, Phe93.B, Ile97.B, Met100.B, Val101.B, Val104.B, Leu107.B | |
| Kir3.2, GIRK2, wild type, mouse, 3syo | |||
| 3syo_EC | E | -11.8 | Pro167.B, Ile170.B, Ile171.B, Met100.C, Val104.C, Leu107.C, Phe141.C, Val142.C |
| F | -11.8 | Met100.B, Val104.B, Leu107.B, Phe141.B, Val142.B, Asp164.D, Pro167.D, Ile170.D, Ile171.D | |
| G | -11.8 | Met100.A, Val104.A, Leu107.A, Phe141.A, Val142.A, Pro167.C, Ile170.C, Ile171.C | |
| H | -11.8 | Ile170.A, Ile171.A, Leu174.A, Leu96.D, Val99.D, Met100.D, Phe141.D, Val142.D | |
| 3syo_IC | F | -14.2 | Trp91.B, Leu95.B, Ile195.B, Lys200.B, Asp81.D, Ile82.D, Phe83.D, Phe108.D, Phe109.D, Leu179.D, Phe186.D |
| G | -14.2 | Ile82.A, Phe83.A, Phe108.A, Phe109.A, Leu179.A, Phe186.A, Trp91.D, Leu95.D, Ile195.D, Lys200.D | |
| H | -14.2 | Trp91.A, Leu95.A, Ile195.A, Lys200.A, Ile82.C, Phe83.C, Phe108.C, Phe109.C, Leu179.C, Phe186.C | |
| I | -14.2 | Ile82.B, Phe83.B, Phe108.B, Phe109.B, Ile175.B, Leu179.B, Phe186.B, Trp91.C, Leu95.C, Ile195.C, Lys200.C | |
| J | -12.4 | Ile82.C, Thr85.C, Leu86.C, Leu89.C, Ile97.C, Met100.C, Val101.C, Val104.C, Phe108.C | |
| K | -12.4 | Ile82.D, Thr85.D, Leu86.D, Leu89.D, Ile97.D, Met100.D, Val101.D, Val104.D, Phe108.D | |
| L | -12.4 | Ile82.B, Thr85.B, Leu86.B, Leu89.B, Ile97.B, Met100.B, Val101.B, Val104.B, Phe108.B | |
| M | -12.3 | Ile82.A, Thr85.A, Leu86.A, Leu89.A, Ile97.A, Met100.A, Val101.A, Val104.A | |
| Kir3.2, GIRK2, R201A mutant, mouse, 3syp | |||
| 3syp_EC | E | -12.4 | Pro167.B, Ile170.B, Ile171.B, Met100.C, Thr103.C, Val104.C, Leu107.C, Phe141.C, Val142.C, Phe145.C |
| E | -12.4 | Met100.A, Thr103.A, Val104.A, Leu107.A, Phe141.A, Val142.A, Phe145.A, Pro167.C, Ile170.C, Ile171.C | |
| G | -12.4 | Met100.B, Thr103.B, Val104.B, Leu107.B, Phe141.B, Val142.B, Phe145.B, Cys166.D, Pro167.D, Ile170.D, Ile171.D | |
| H | -12.4 | Cys166.A, Pro167.A, Ile170.A, Ile171.A, Met100.D, Thr103.D, Val104.D, Leu107.D, Phe141.D, Val142.D, Phe145.D | |
| I | -12.3 | Phe108.C, Ile112.C, Leu115.C, Ile116.C, Glu168.C, Leu172.C, Ile175.C, Leu179.C | |
| J | -12.4 | Phe108.A, Ile112.A, Leu115.A, Ile116.A, Glu168.A, Leu172.A, Ile175.A, Leu179.A | |
| K | -12.3 | Phe108.D, Ile112.D, Leu115.D, Ile116.D, Glu168.D, Leu172.D, Ile175.D, Leu179.D | |
| L | -12.3 | Phe108.B, Ile112.B, Leu115.B, Ile116.B, Glu168.B, Leu172.B, Ile175.B, Leu179.B | |
| 3syp_IC | E | -12.5 | Lys200.A, Ile82.C, Phe83.C, Leu86.C, Val101.C, Val104.C, Phe108.C, Phe186.C |
| F | -12.5 | Asp81.B, Ile82.B, Phe83.B, Leu86.B, Val101.B, Val104.B, Phe108.B, Phe186.B, Lys200.C | |
| G | -12.5 | Asp81.A, Ile82.A, Phe83.A, Leu86.A, Val101.A, Val104.A, Phe108.A, Phe186.A, Lys200.D | |
| H | -12.5 | Ile195.B, Lys200.B, Ile82.D, Phe83.D, Leu86.D, Val101.D, Val104.D, Phe108.D, Phe186.D | |
| I | -12.3 | Ile82.A, Phe83.A, Phe108.A, Leu179.A, Ile182.A, Phe186.A, Trp91.D, Leu95.D, Ile195.D, Lys200.D | |
| J | -12.3 | Trp91.B, Leu95.B, Ile195.B, Lys200.B, Asp81.D, Ile82.D, Phe83.D, Phe108.D, Leu179.D, Ile182.D, Phe186.D | |
| K | -12.3 | Asp81.B, Ile82.B, Phe83.B, Phe108.B, Leu179.B, Ile182.B, Phe186.B, Trp91.C, Leu95.C, Ile195.C, Lys200.C | |
| L | -12.3 | Trp91.A, Leu95.A, Ile195.A, Lys200.A, Ile82.C, Phe83.C, Leu86.C, Phe108.C, Leu179.C, Ile182.C, Phe186.C | |
| Kir3.2, GIRK2, R201A mutant plus PIP2, mouse, 3syq | |||
| 3syq_EC | E | -12.9 | Met100.C, Thr103.C, Val104.C, Leu107.C, Phe141.C, Val142.C, Cys166.D, Pro167.D, Ile170.D, Ile171.D, Leu174.D |
| F | -12.9 | Cys166.A, Pro167.A, Ile170.A, Ile171.A, Met100.D, Thr103.D, Val104.D, Leu107.D, Phe141.D, Val142.D, Phe145.D | |
| G | -12.9 | Met100.A, Thr103.A, Val104.A, Leu107.A, Phe141.A, Val142.A, Asp164.B, Cys166.B, Pro167.B, Ile170.B, Ile171.B, Leu174.B | |
| H | -12.9 | Met100.B, Thr103.B, Val104.B, Leu107.B, Phe141.B, Val142.B, Phe145.B, Cys166.C, Pro167.C, Ile170.C, Ile171.C | |
| I | -12.8 | Leu95.C, Phe108.D, Ile112.D, Leu115.D, Ile116.D, Glu168.D, Leu172.D, Ile175.D, Leu179.D | |
| J | -12.8 | Leu95.A, Phe108.B, Ile112.B, Leu115.B, Ile116.B, Glu168.B, Leu172.B, Ile175.B, Leu179.B | |
| K | -12.4 | Phe108.C, Ile112.C, Leu115.C, Ile116.C, Glu168.C, Leu172.C, Ile175.C, Leu179.C | |
| L | -12.4 | Phe108.A, Ile112.A, Leu115.A, Ile116.A, Glu168.A, Leu172.A, Ile175.A, Leu179.A | |
| 3syq_IC | G | -12.9 | Ile82.D, Thr85.D, Leu86.D, Ile97.D, Met100.D, Val101.D, Val104.D, Phe186.D |
| H | -12.8 | Ile82.B, Thr85.B, Leu86.B, Ile97.B, Met100.B, Val101.B, Val104.B, Phe186.B | |
| I | -12.5 | Trp91.C, Ile195.C, Ile82.D, Phe83.D, Val101.D, Val104.D, Phe108.D, Ile182.D, Phe186.D | |
| J | -14.0 | Trp91.A, Ile195.A, Ile82.B, Phe83.B, Val101.B, Val104.B, Leu107.B, Phe108.B, Phe186.B | |
| K | -12.6 | Trp91.C, Leu95.C, Ile82.D, Phe108.D, Phe109.D, Leu172.D, Ile175.D, Leu179.D | |
| L | -11.9 | Phe108.A, Phe109.A, Ile112.A, Leu172.A, Ile175.A, Leu179.A, Trp91.D, Arg92.D, Leu95.D | |
| M | -12.8 | Trp91.A, Leu95.A, Ile82.B, Phe108.B, Phe109.B, Leu172.B, Ile175.B, Leu179.B | |
| Kir3.2, GIRK2, complex with βγ G protein subunits, human, 4kfm | |||
| 4kfm_EC | B | -12.0 | Pro167.C, Ile170.C, Ile171.C, Leu174.C, Leu96.F, Val99.F, Met100.F, Thr103.F, Leu107.F, Phe141.F, Val142.F |
| D | -12.0 | Leu96.A, Val99.A, Met100.A, Thr103.A, Leu107.A, Phe141.A, Val142.A, Pro167.F, Ile170.F, Ile171.F, Leu174.F | |
| E | -12.0 | Pro167.A, Ile170.A, Ile171.A, Leu174.A, Leu96.J, Val99.J, Met100.J, Thr103.J, Leu107.J, Phe141.J, Val142.J | |
| G | -12.0 | Leu96.C, Val99.C, Met100.C, Thr103.C, Leu107.C, Phe141.C, Val142.C, Pro167.J, Ile170.J, Ile171.J, Leu174.J | |
| 4kfm_IC | [none] | ||
| Kir6.2 | |||
| Kir6.2, with glibenclamide and ATPγS, mouse, 5yke | |||
| 5yke_EC | B | -14.8 | Pro143.C, Ile146.C, Leu147.C, Ile150.C, Leu73.E, Thr76.E, Met77.E, Leu80.E, Phe117.E, Ser118.E, Phe121.E |
| D | -14.8 | Leu73.A, Thr76.A, Met77.A, Leu80.A, Leu84.A, Phe117.A, Ser118.A, Phe121.A, Pro143.G, Ile146.G, Leu147.G, Ile150.G | |
| F | -14.7 | Pro143.A, Ile146.A, Leu147.A, Ile150.A, Thr76.C, Met77.C, Leu80.C, Leu84.C, Phe117.C, Ser118.C, Phe121.C | |
| I | -14.7 | Pro143.E, Ile146.E, Leu147.E, Ile150.E, Leu73.G, Thr76.G, Met77.G, Leu80.G, Leu84.G, Phe117.G, Ser118.G, Phe121.G | |
| J | -13.6 | Met77.G, Leu84.G, Phe117.G, Val33.H, Val37.H, Phe41.H, Phe44.H, Leu104.H, His105.H, Met108.H, Met112.H | |
| K | -12.8 | Leu311.H, Phe314.H, Leu318.H, Val443.H, Val447.H, Ile450.H, Leu451.H, Tyr454.H | |
| L | -12.7 | Val86.H, Ile89.H, Ala90.H, Ile93.H, Leu94.H, Tyr356.H, Val357.H, Val360.H | |
| M | -13.6 | Val1163.H, Ala1167.H, Pro1170.H, Ile1262.H, Ala1265.H, Thr1266.H, Ser1269.H, Asn1270.H | |
| N | -12.4 | His1024.H, Met1025.H, Tyr1032.H, Leu1148.H, Val1151.H, Ser1152.H, Thr1155.H, Tyr1159.H | |
| 5yke_IC | B | -16.2 | Ile76.H, Phe79.H, Ile80.H, Phe83.H, Leu224.H, Leu225.H, Lys227.H, Gly228.H, Phe305.H, Leu368.H, Thr371.H, Phe372.H, Ala375.H |
| D | -14.3 | Val1151.H, Leu1154.H, Leu1165.H, Leu1168.H, Leu1169.H, Ala1172.H, Cys1175.H, Gln1179.H, Met1298.H, Val1299.H, Leu1302.H | |
| F | -14.2 | Trp75.H, Leu82.H, Val86.H, Phe114.H, Ile118.H, Val121.H, His125.H, Leu225.H, Phe363.H, Leu364.H | |
| I | -13.8 | Trp75.H, Phe114.H, Met115.H, Ile118.H, Val121.H, Val122.H, His125.H, Asn223.H, Leu225.H | |
| J | -13.5 | Trp231.H, Asn234.H, Leu1171.H, Val1174.H, Trp1247.H, Arg1251.H, Ile1255.H, Cys1258.H, Ile1262.H | |
| K | -13.0 | Val59.G, Phe60.G, Leu63.G, Leu85.G, Phe86.G, Val155.G, Ile159.G, Ile162.G, Phe38.H, Ile42.H | |
| Kir6.2, with ATP and glibenclamide, rat, 6baa | |||
| 6baa_EC | E | -14.6 | Phe83.F, Leu308.F, Leu312.F, Ala315.F, Asn354.F, Val357.F, Leu358.F, Leu361.F, Phe372.F |
| G | -14.5 | Tyr356.F, Ala1167.F, Pro1170.F, Leu1171.F, Cys1258.F, Ile1262.F, Ala1265.F, Thr1266.F, Ser1269.F | |
| H | -14.1 | Ile462.F, Ala465.F, Leu469.F, Ile557.F, Val560.F, Gly561.F, Ser564.F, Phe565.F | |
| I | -13.5 | Pro143.A, Ile146.A, Leu147.A, Ile150.A, Leu73.B, Thr76.B, Leu80.B, Leu84.B, Ser118.B | |
| J | -13.5 | Pro143.B, Ile146.B, Leu147.B, Ile150.B, Leu73.C, Thr76.C, Leu80.C, Leu84.C, Ser118.C | |
| K | -13.4 | Leu73.A, Met77.A, Leu80.A, Leu84.A, Ser118.A, Pro143.D, Ile146.D, Leu147.D, Ile150.D | |
| L | -13.5 | Ile146.C, Leu147.C, Ile150.C, Leu73.D, Thr76.D, Leu80.D, Leu84.D, Phe117.D, Ser118.D, Phe121.D | |
| M | -13.3 | Val86.F, Ile89.F, Ala90.F, Ile93.F, Tyr356.F, Val360.F, Phe363.F, Leu1261.F | |
| N | -13.3 | Leu84.B, Phe117.B, Leu40.F, Phe44.F, His105.F, Met108.F, Met112.F, Met115.F | |
| O | -13.2 | Ile307.F, Leu311.F, Leu318.F, Val443.F, Val447.F, Ile450.F, Leu451.F, Tyr454.F | |
| P | -12.5 | Leu85.B, Phe86.B, Val89.B, Leu92.B, Ala96.B, Leu144.B, Val151.B, Val155.B, Phe27.F, Leu31.F, Val34.F | |
| Q | -12.8 | Phe545.F, Leu556.F, Ile557.F, Val560.F, Gly561.F, Ser564.F, Cys1072.F, Ile1076.F | |
| 6baa_IC | E | -15.8 | Trp75.F, Phe79.F, Leu82.F, Val86.F, Phe114.F, Ile118.F, Val121.F, Val122.F, His125.F, Asn223.F, Leu225.F, Phe363.F, Leu364.F |
| G | -14.4 | Phe44.F, Leu47.F, Trp51.F, Gln54.F, Met115.F, Thr119.F, Val122.F, Asn126.F | |
| H | -14.2 | Thr1147.F, Val1151.F, Leu1154.F, Ser1158.F, Leu1165.F, Leu1168.F, Gln1179.F, Met1298.F, Val1299.F, Leu1302.F | |
| I | -14.2 | Trp231.F, Asn234.F, Leu1171.F, Trp1247.F, Cys1251.F, Tyr1254.F, Cys1258.F, Leu1261.F, Ile1262.F | |
| J | -13.6 | Leu140.F, Thr144.F, Leu145.F, Ile148.F, Val187.F, Ile190.F, Arg191.F, Arg194.F, Ile196.F | |
| Kir6.2, with repaglinide and ATPγS, mouse, 6jb1 | |||
| 6jb1_EC | D | -14.6 | Tyr356.B, Leu1171.B, Cys1258.B, Leu1261.B, Ile1262.B, Ala1265.B, Thr1266.B, Ser1269.B |
| F | -14.0 | Pro143.A, Ile146.A, Leu147.A, Ile150.A, Leu73.G, Met77.G, Leu80.G, Leu84.G, Phe117.G, Ser118.G, Phe121.G | |
| H | -14.0 | Leu308.B, Leu312.B, Ala315.B, Leu318.B, Cys319.B, Gly322.B, Leu352.B, Gly353.B, Leu358.B, Leu361.B | |
| I | -13.9 | Leu73.A, Met77.A, Leu80.A, Leu84.A, Phe117.A, Ser118.A, Phe121.A, Pro143.C, Ile146.C, Leu147.C, Ile150.C | |
| J | -13.9 | Leu73.E, Leu80.E, Leu84.E, Phe117.E, Ser118.E, Phe121.E, Ile146.G, Leu147.G, Ile150.G | |
| K | -13.8 | Leu73.C, Met77.C, Leu80.C, Leu84.C, Phe117.C, Ser118.C, Phe121.C, Pro143.E, Ile146.E, Leu147.E, Ile150.E | |
| L | -14.3 | Val86.B, Ala90.B, Ile93.B, Leu94.B, Asn354.B, Tyr356.B, Val357.B, Val360.B | |
| M | -13.8 | Met77.A, Leu84.A, Phe117.A, Phe5.B, Val37.B, Leu40.B, Phe41.B, Phe44.B, Phe48.B, Met108.B, Met112.B, Met115.B | |
| N | -13.7 | Ile80.B, Phe83.B, Leu167.B, Cys170.B, Leu171.B, Leu174.B, Leu312.B, Ser348.B, Gln349.B, Leu352.B, Leu368.B | |
| O | -13.0 | Val89.A, Leu92.A, Ile93.A, Ala96.A, Leu144.A, Phe27.B, Leu31.B, Ile141.B, Leu145.B | |
| P | -12.9 | Leu85.A, Val89.A, Leu92.A, Ala96.A, Leu144.A, Val21.B, Phe27.B, Leu31.B, Val34.B, Phe38.B, Ile42.B, Leu145.B | |
| Q | -12.6 | Phe545.B, Met546.B, Ile550.B, Ala553.B, Leu556.B, Ile557.B, Val560.B, Ser564.B, Thr1069.B, Ile1076.B | |
| 6jb1_IC | D | -15.2 | Cys1150.B, Val1151.B, Leu1154.B, Thr1155.B, Ser1158.B, Leu1165.B, Leu1168.B, Cys1175.B, Tyr1176.B, Gln1179.B, |
| F | -15.0 | Asn547.B, Thr548.B, Pro551.B, Ile552.B, Val555.B, Leu580.B, His584.B, Val587.B, Thr588.B, Phe591.B, Leu592.B, | |
| H | -13.3 | Trp231.B, Asn234.B, Ala1167.B, Leu1171.B, Val1174.B, Ile1178.B, Arg1251.B, Ile1255.B, Cys1258.B, Ile1262.B | |
| I | -13.6 | Leu85.A, Phe86.A, Val151.A, Ile42.B, Ile46.B, Lys134.B, Leu135.B, Ile137.B, Ile141.B | |
| J | -13.1 | Trp75.B, Leu82.B, Val86.B, Phe114.B, Ile118.B, Val121.B, Val122.B, His125.B, Asn223.B, Leu225.B | |
| K | -15.0 | Phe44.B, Leu47.B, Phe48.B, Trp51.B, Met115.B, Ile118.B, Val122.B, Asn126.B | |
| Voltage-gated Kv channels | |||
| Kv1.2 | |||
| Kv1.2, rat, 2a79 | |||
| 2a79_EC | A | -15.8 | Leu328.F, Ile332.F, Leu335.F, Pro362.F, Phe365.F, Val369.F, Ile385.N, Lys388.N, Ile389.N, Ser392.N, Leu393.N |
| E | -15.5 | Ile385.B, Lys388.B, Ile389.B, Ser392.B, Leu393.B, Leu328.N, Ile332.N, Leu335.N, Pro362.N, Asp363.N, Phe365.N, Trp366.N, Val369.N | |
| M | -12.6 | Phe223.B, Thr227.B, Ile230.B, Ile231.B, Ser234.B, Phe235.B, Leu238.B, Ala14.D, Ala17.D | |
| Q | -15.7 | Ile385.F, Lys388.F, Ile389.F, Ser392.F, Leu393.F, Leu328.J, Ile332.J, Leu335.J, Pro362.J, Phe365.J, Trp366.J, Val369.J | |
| R | -12.6 | Phe223.F, Thr227.F, Ile230.F, Ile231.F, Ser234.F, Phe235.F, Leu238.F, Ala14.H, Ala17.H | |
| S | -12.4 | Phe223.N, Thr227.N, Ile230.N, Ile231.N, Ser234.N, Phe235.N, Leu238.N, Ala14.P, Ala17.P | |
| T | -12.3 | Phe223.J, Thr227.J, Ile230.J, Ile231.J, Ser234.J, Phe235.J, Leu238.J, Ala14.L, Ala17.L | |
| U | -15.5 | Leu328.B, Ile332.B, Leu335.B, Pro362.B, Phe365.B, Trp366.B, Val369.B, Ile385.J, Lys388.J, Ile389.J, Ser392.J, Leu393.J | |
| 2a79_IC | A | -13.1 | His310.B, Ser311.B, Lys312.B, Gly313.B, Tyr417.B, Arg326.J, Leu330.J, Phe333.J |
| E | -13.2 | Arg326.F, Leu330.F, Phe333.F, His310.J, Ser311.J, Lys312.J, Gly313.J, Tyr417.J, Ala46.K | |
| I | -12.8 | His310.F, Ala34.G, Ala35.G, Ala38.G, Ala39.G, Ala42.G, Ala46.G, Phe336.N | |
| M | -12.8 | Ser311.F, Lys312.F, Gly313.F, Arg326.N, Gly329.N, Leu330.N, Ile332.N, Phe333.N | |
| Q | -12.7 | His310.J, Lys312.J, Ala34.K, Ala35.K, Ala38.K, Ala39.K, Ala42.K, Ala46.K | |
| R | -12.9 | Phe333.B, Phe336.B, Leu307.N, His310.N, Lys312.N, Ala34.O, Ala35.O, Ala38.O, Ala39.O, Ala42.O | |
| S | -12.8 | His310.B, Ala34.C, Ala35.C, Ala38.C, Ala39.C, Ala42.C, Ala46.C, Phe336.J | |
| T | -13.7 | Arg326.B, Gly329.B, Leu330.B, Ile332.B, Phe333.B, Ser311.N, Lys312.N, Gly313.N | |
| Kv1.2/Kv2.1 paddle chimera, rat, 2r9r | |||
| 2r9r_EC | A | -15.2 | Ile381.B, Lys384.B, Ile385.B, Ile328.D, Phe329.D, Phe332.D, Pro358.D, Asp359.D, Phe361.D, Trp362.D, Val365.D |
| C | -15.2 | Ile381.D, Lys384.D, Ile385.D, Ile328.H, Phe329.H, Phe332.H, Pro358.H, Asp359.H, Phe361.H, Trp362.H, Val365.H | |
| E | -13.8 | Gln214.H, Ser215.H, Thr216.H, Phe218.H, Phe223.H, Leu238.H, Tyr266.H, Tyr267.H, Ile270.H | |
| G | -13.8 | Gln214.F, Ser215.F, Thr216.F, Phe218.F, Phe223.F, Leu238.F, Tyr266.F, Tyr267.F, Ile270.F | |
| I | -13.8 | Ser215.D, Thr216.D, Phe218.D, Phe223.D, Leu238.D, Tyr266.D, Tyr267.D, Ile270.D | |
| J | -13.2 | Leu337.B, Phe338.B, Ala341.B, Ala345.B, Val386.B, Leu389.B, Ile291.D, Ile294.D, Phe301.D | |
| K | -13.1 | Leu337.D, Phe338.D, Ala341.D, Ala345.D, Val386.D, Ile291.H, Ile294.H, Phe301.H | |
| L | -15.2 | Ile328.F, Phe329.F, Phe332.F, Pro358.F, Asp359.F, Phe361.F, Trp362.F, Val365.F, Ile381.H, Lys384.H, Ile385.H | |
| M | -15.2 | Ile328.B, Phe329.B, Phe332.B, Pro358.B, Asp359.B, Phe361.B, Trp362.B, Val365.B, Ile381.F, Lys384.F, Ile385.F | |
| N | -13.8 | Gln214.B, Ser215.B, Thr216.B, Phe218.B, Phe223.B, Leu238.B, Tyr266.B, Tyr267.B, Ile270.B | |
| O | -13.2 | Ile291.F, Ile294.F, Phe301.F, Leu337.H, Phe338.H, Ala341.H, Ala345.H, Val386.H, Leu389.H | |
| P | -13.1 | Ile291.B, Ile294.B, Phe301.B, Leu337.F, Phe338.F, Ala341.F, Ala345.F, Val386.F, Leu389.F | |
| 2r9r_IC | A | -15.7 | Arg322.D, Leu326.D, Phe329.D, Leu174.H, His306.H, Ser307.H, Lys308.H, Gly309.H |
| C | -14.1 | Leu174.F, Val178.F, Leu303.F, His306.F, Ser307.F, Lys308.F, Gly309.F, Arg322.H, Leu326.H, Phe329.H, Phe332.H | |
| E | -12.8 | Phe145.D, Gln146.D, Val149.D, Ile231.D, Phe235.D, Leu238.D, Val239.D, Phe242.D, Ala243.D | |
| G | -12.7 | Phe145.H, Gln146.H, Val149.H, Ile231.H, Phe235.H, Leu238.H, Val239.H, Phe242.H, Ala243.H | |
| I | -12.6 | Phe145.F, Gln146.F, Val149.F, Ile231.F, Phe235.F, Leu238.F, Val239.F, Phe242.F, Ala243.F | |
| J | -15.8 | Leu174.B, His306.B, Ser307.B, Lys308.B, Gly309.B, Leu310.B, Arg322.F, Leu326.F, Phe329.F | |
| K | -15.8 | Arg322.B, Leu326.B, Ile328.B, Phe329.B, Ser307.D, Lys308.D, Gly309.D, Leu310.D | |
| L | -12.8 | Phe145.B, Gln146.B, Val149.B, Ile231.B, Phe235.B, Leu238.B, Val239.B, Phe242.B, Ala243.B | |
| Kv1.2/Kv2.1 paddle chimera, rat,3lnm | |||
| 3lnm_EC | A | -15.2 | Ile328.B, Phe329.B, Phe332.B, Pro358.B, Asp359.B, Phe361.B, Trp362.B, Val365.B, Ile381.S, Lys384.S, Ile385.S, Ser388.S |
| C | -15.1 | Ile328.S, Phe329.S, Phe332.S, Pro358.S, Asp359.S, Phe361.S, Trp362.S, Val365.S, Ile381.U, Lys384.U, Ile385.U, Ser388.U | |
| D | -13.9 | Gln214.I, Ser215.I, Thr216.I, Phe218.I, Phe223.I, Thr227.I, Ile231.I, Leu238.I, Tyr266.I, Tyr267.I, Ile270.I | |
| E | -13.9 | Gln214.B, Ser215.B, Thr216.B, Phe218.B, Phe223.B, Thr227.B, Ile231.B, Leu238.B, Tyr266.B, Tyr267.B, Ile270.B | |
| F | -13.8 | Gln214.S, Ser215.S, Thr216.S, Phe218.S, Phe223.S, Thr227.S, Ile231.S, Leu238.S, Tyr266.S, Tyr267.S, Ile270.S | |
| G | -15.1 | Ile381.B, Lys384.B, Ile385.B, Ser388.B, Ile328.I, Phe329.I, Phe332.I, Pro358.I, Asp359.I, Phe361.I, Trp362.I, Val365.I | |
| H | -15.1 | Ile381.I, Lys384.I, Ile385.I, Ser388.I, Ile328.U, Phe329.U, Phe332.U, Pro358.U, Asp359.U, Phe361.U, Trp362.U, Val365.U | |
| J | -13.9 | Gln214.I, Ser215.I, Thr216.I, Phe218.I, Phe223.I, Thr227.I, Ile231.I, Leu238.I, Tyr266.I, Tyr267.I, Ile270.I | |
| K | -13.9 | Gln214.U, Ser215.U, Thr216.U, Phe218.U, Phe223.U, Thr227.U, Ile231.U, Leu238.U, Tyr266.U, Tyr267.U, Ile270.U | |
| L | -13.8 | Gln214.S, Ser215.S, Thr216.S, Phe218.S, Phe223.S, Thr227.S, Ile231.S, Leu238.S, Tyr266.S, Tyr267.S, Ile270.S | |
| 3lnm_IC | A | -16.6 | Val170.B, Leu174.B, Val178.B, Leu303.B, His306.B, Ser307.B, Lys308.B, Gly309.B, Arg322.S, Leu326.S, Phe329.S |
| C | -16.5 | Arg322.B, Leu326.B, Phe329.B, Val170.I, Leu174.I, Val178.I, Leu303.I, His306.I, Ser307.I, Lys308.I, Gly309.I | |
| D | -14.1 | Phe145.S, Val149.S, Ile231.S, Phe235.S, Leu238.S, Val239.S, Phe242.S, Ala243.S | |
| E | -14.1 | Phe145.B, Val149.B, Ile231.B, Phe235.B, Leu238.B, Val239.B, Phe242.B, Ala243.B | |
| F | -14.0 | Phe145.I, Gln146.I, Ile231.I, Phe235.I, Leu238.I, Val239.I, Phe242.I, Ala243.I | |
| G | -12.6 | Ile254.S, Phe301.S, Gly314.S, Leu317.S, Lys318.S, Leu337.U, Phe338.U, Ala341.U | |
| H | -12.6 | Leu337.B, Phe338.B, Ala341.B, Ile254.I, Phe301.I, Gly314.I, Leu317.I, Lys318.I | |
| J | -16.5 | Arg322.I, Leu326.I, Phe329.I, Val170.U, Leu174.U, Val178.U, Leu303.U, His306.U, Ser307.U, Lys308.U, Gly309.U | |
| K | -16.4 | Val170.S, Leu174.S, Val178.S, Leu303.S, His306.S, Ser307.S, Lys308.S, Gly309.S, Arg322.U, Leu326.U, Phe329.U | |
| L | -14.1 | Phe145.U, Gln146.U, Ile231.U, Phe235.U, Leu238.U, Val239.U, Phe242.U, Ala243.U | |
| M | -12.6 | Leu337.I, Phe338.I, Ala341.I, Leu389.I, Ile254.U, Phe301.U, Gly314.U, Leu317.U, Lys318.U | |
| Kv1.2/Kv2.1 paddle chimera, rat, 3lut | |||
| 3lut_EC | [none] | ||
| 3lut_IC | [npne] | ||
| Kv1.2/Kv2.1 paddle chimera, plus CTX, rat,4jta | |||
| 4jta_EC | C | -14.6 | Ile328.A, Phe332.A, Pro358.A, Asp359.A, Phe361.A, Trp362.A, Val365.A, Ile381.F, Lys384.F, Ile385.F, Ser388.F |
| E | -14.3 | Ile381.D, Lys384.D, Ile385.D, Ser388.D, Ile328.F, Phe329.F, Phe332.F, Pro358.F, Asp359.F, Phe361.F, Trp362.F, Val365.F | |
| G | -12.8 | Gln214.A, Ser215.A, Thr216.A, Phe218.A, Phe223.A, Leu238.A, Tyr266.A, Tyr267.A, Ile270.A | |
| H | -12.8 | Leu337.D, Phe338.D, Ala341.D, Ala345.D, Val386.D, Ile291.F, Ile294.F, Phe301.F | |
| I | -12.6 | Ile291.A, Ile294.A, Phe301.A, Leu337.F, Phe338.F, Ala341.F, Ala345.F, Val386.F, Leu389.F | |
| J | -12.9 | Gln214.F, Ser215.F, Thr216.F, Phe218.F, Phe223.F, Leu238.F, Tyr266.F, Tyr267.F, Ile270.F | |
| K | -12.9 | Ser215.B, Thr216.B, Phe218.B, Phe223.B, Leu238.B, Tyr266.B, Tyr267.B, Ile270.B | |
| L | -12.7 | Ser234.A, Phe237.A, Leu238.A, Tyr267.A, Ile270.A, Phe271.A, Glu274.A, Ser275.A | |
| M | -12.8 | Phe329.A, Phe332.A, Ile336.A, Pro358.A, Phe361.A, Leu174.B, Ile177.B, Val178.B, Cys181.B, Leu182.B, Leu185.B | |
| N | -12.3 | Leu174.A, Val178.A, Leu182.A, Leu185.A, Ile381.D, Phe332.F, Pro358.F, Phe361.F | |
| O | -12.5 | Ser234.D, Phe237.D, Leu238.D, Ile263.D, Tyr267.D, Ile270.D, Phe271.D, Glu274.D | |
| P | -14.6 | Ile381.A, Lys384.A, Ile385.A, Ser388.A, Ile328.B, Phe332.B, Pro358.B, Asp359.B, Phe361.B, Trp362.B, Val365.B | |
| Q | -14.5 | Ile381.B, Lys384.B, Ile385.B, Ser388.B, Ile328.D, Phe332.D, Pro358.D, Asp359.D, Phe361.D, Trp362.D, Val365.D | |
| R | -12.8 | Gln214.D, Ser215.D, Thr216.D, Phe218.D, Phe223.D, Leu238.D, Tyr266.D, Tyr267.D, Ile270.D | |
| S | -12.8 | Leu337.A, Phe338.A, Ala341.A, Ala345.A, Val386.A, Ile291.B, Ile294.B, Phe301.B | |
| T | -12.6 | Leu337.B, Phe338.B, Ala341.B, Ala345.B, Val386.B, Leu389.B, Ile291.D, Ile294.D, Phe301.D | |
| U | -13.0 | Ser234.B, Phe237.B, Leu238.B, Ile263.B, Tyr267.B, Phe271.B, Glu274.B, Ser275.B | |
| V | -12.9 | Phe329.D, Phe332.D, Ile336.D, Pro358.D, Phe361.D, Leu174.F, Ile177.F, Val178.F, Cys181.F, Leu182.F, Leu185.F | |
| W | -12.7 | Phe329.B, Phe332.B, Ile336.B, Pro358.B, Phe361.B, Leu174.D, Ile177.D, Val178.D, Leu182.D, Leu185.D, Leu303.D | |
| 4jta_IC | C | -14.9 | Arg322.A, Leu326.A, Phe329.A, Phe332.A, Leu174.B, His306.B, Ser307.B, Lys308.B, Gly309.B |
| E | -14.9 | Leu174.A, His306.A, Ser307.A, Lys308.A, Gly309.A, Arg322.F, Leu326.F, Phe329.F, Phe332.F | |
| G | -13.7 | Phe145.A, Gln146.A, Val149.A, Ile231.A, Phe235.A, Leu238.A, Val239.A, Phe242.A, Ala243.A | |
| H | -13.7 | Phe145.F, Gln146.F, Val149.F, Phe235.F, Leu238.F, Val239.F, Phe242.F, Ala243.F | |
| I | -13.4 | Phe145.B, Gln146.B, Val149.B, Phe235.B, Leu238.B, Val239.B, Phe242.B, Ala243.B | |
| J | -13.0 | Ile254.A, Phe301.A, Gly314.A, Leu317.A, Lys318.A, Leu337.F, Phe338.F, Ala341.F, Leu389.F | |
| K | -12.9 | Leu337.D, Phe338.D, Ala341.D, Leu389.D, Ile254.F, Phe301.F, Gly314.F, Leu317.F, Lys318.F | |
| L | -12.3 | Leu152.A, Phe153.A, Pro161.A, Ile165.A, Val168.A, Leu228.A, Ile231.A, Trp232.A, Phe235.A | |
| M | -12.3 | Leu152.B, Phe153.B, Pro161.B, Ile165.B, Val168.B, Leu228.B, Ile231.B, Trp232.B, Phe235.B | |
| N | -14.9 | Arg322.B, Leu326.B, Phe329.B, Phe332.B, Leu174.D, His306.D, Ser307.D, Lys308.D, Gly309.D | |
| O | -14.9 | Arg322.D, Leu326.D, Phe329.D, Phe332.D, Leu174.F, His306.F, Ser307.F, Lys308.F, Gly309.F | |
| P | -13.8 | Phe145.D, Gln146.D, Val149.D, Ile231.D, Phe235.D, Leu238.D, Val239.D, Phe242.D, Ala243.D | |
| Q | -13.0 | Leu337.B, Phe338.B, Ala341.B, Leu389.B, Ile254.D, Phe301.D, Gly314.D, Leu317.D, Lys318.D | |
| R | -12.9 | Leu337.A, Phe338.A, Ala341.A, Leu389.A, Ile254.B, Phe301.B, Gly314.B, Leu317.B, Lys318.B | |
| S | -12.3 | Leu152.D, Phe153.D, Pro161.D, Ile165.D, Val168.D, Leu228.D, Ile231.D, Trp232.D, Phe235.D | |
| T | -12.3 | Leu152.F, Phe153.F, Pro161.F, Ile165.F, Val168.F, Leu228.F, Ile231.F, Trp232.F, Phe235.F | |
| Kv1.2/Kv2.1 paddle chimera, plus CTX, rat,4jtc | |||
| 4jtc_EC | A | -16.1 | Ile381.B, Lys384.B, Ile385.B, Ser388.B, Ile328.F, Phe329.F, Phe332.F, Pro358.F, Asp359.F, Phe361.F, Trp362.F, Val365.F |
| C | -16.0 | Ile328.D, Phe329.D, Phe332.D, Pro358.D, Asp359.D, Phe361.D, Trp362.D, Val365.D, Ile381.F, Lys384.F, Ile385.F, Ser388.F | |
| E | -12.9 | Ser215.D, Thr216.D, Phe218.D, Phe223.D, Ile231.D, Phe235.D, Leu238.D, Tyr266.D, Tyr267.D, Ile270.D | |
| G | -12.9 | Ser215.H, Thr216.H, Phe218.H, Phe223.H, Ile231.H, Phe235.H, Leu238.H, Tyr266.H, Tyr267.H, Ile270.H | |
| I | -12.8 | Gln214.F, Ser215.F, Thr216.F, Phe218.F, Phe223.F, Ile231.F, Phe235.F, Leu238.F, Tyr266.F, Tyr267.F, Ile270.F | |
| J | -12.4 | Leu337.B, Ala341.B, Phe344.B, Ala345.B, Gly382.B, Val386.B, Leu389.B, Ile294.F, Phe301.F | |
| K | -12.3 | Ile294.D, Phe301.D, Leu337.F, Ala341.F, Phe344.F, Ala345.F, Gly382.F, Val386.F, Leu389.F | |
| L | -16.1 | Ile381.D, Lys384.D, Ile385.D, Ser388.D, Ile328.H, Phe329.H, Phe332.H, Pro358.H, Asp359.H, Phe361.H, Trp362.H, Val365.H | |
| M | -16.0 | Ile328.B, Phe329.B, Phe332.B, Pro358.B, Asp359.B, Phe361.B, Trp362.B, Val365.B, Ile381.H, Lys384.H, Ile385.H, Ser388.H | |
| N | -12.9 | Ser215.B, Thr216.B, Phe218.B, Phe223.B, Ile231.B, Phe235.B, Leu238.B, Tyr266.B, Tyr267.B, Ile270.B | |
| O | -12.4 | Leu337.D, Ala341.D, Phe344.D, Ala345.D, Gly382.D, Val386.D, Leu389.D, Ile294.H, Phe301.H | |
| P | -12.3 | Ile294.B, Phe301.B, Leu337.H, Ala341.H, Phe344.H, Ala345.H, Gly382.H, Val386.H, Leu389.H | |
| 4jtc_IC | A | -14.2 | His306.D, Ser307.D, Lys308.D, Gly309.D, Arg322.F, Leu326.F, Ile328.F, Phe329.F |
| C | -14.2 | Leu326.D, Phe329.D, Leu174.H, His306.H, Ser307.H, Lys308.H, Gly309.H, Leu310.H | |
| E | -13.3 | Ile254.F, Ile258.F, Met295.F, Leu298.F, Phe301.F, Gly314.F, Gln315.F, Leu317.F, Lys318.F | |
| G | -13.3 | Ile254.D, Ile258.D, Met295.D, Leu298.D, Phe301.D, Gly314.D, Gln315.D, Leu317.D, Lys318.D | |
| I | -14.2 | His306.B, Ser307.B, Lys308.B, Gly309.B, Arg322.H, Leu326.H, Ile328.H, Phe329.H | |
| J | -13.7 | Arg322.B, Leu326.B, Phe329.B, Leu174.F, His306.F, Ser307.F, Lys308.F, Gly309.F | |
| K | -13.3 | Ile254.H, Ile258.H, Met295.H, Leu298.H, Phe301.H, Gly314.H, Gln315.H, Leu317.H, Lys318.H | |
| L | -13.2 | Ile254.B, Ile258.B, Met295.B, Leu298.B, Phe301.B, Gly314.B, Gln315.B, Leu317.B, Lys318.B | |
| Kv1.2/Kv2.1 paddle chimera, plus CTX and CsCl, rat,4jtd | |||
| 4jtd_EC | A | -15.1 | Gly325.D, Ile328.D, Phe329.D, Phe332.D, Pro358.D, Asp359.D, Phe361.D, Trp362.D, Val365.D, Ile381.F, Lys384.F, Ile385.F, Ser388.F |
| C | -15.1 | Ile381.B, Lys384.B, Ile385.B, Ser388.B, Gly325.F, Ile328.F, Phe329.F, Phe332.F, Pro358.F, Asp359.F, Phe361.F, Trp362.F, Val365.F | |
| E | -12.7 | Leu337.B, Ala341.B, Phe344.B, Ala345.B, Gly382.B, Val386.B, Leu389.B, Ile294.F, Phe301.F | |
| G | -12.6 | Ile294.D, Phe301.D, Leu337.F, Ala341.F, Phe344.F, Ala345.F, Gly382.F, Val386.F, Leu389.F | |
| I | -12.5 | Ile294.B, Ala341.H, Phe344.H, Ala345.H, Glu346.H, Gly382.H, Ile385.H, Val386.H, Leu389.H | |
| J | -15.1 | Gly325.B, Ile328.B, Phe329.B, Phe332.B, Pro358.B, Asp359.B, Phe361.B, Trp362.B, Val365.B, Ile381.H, Lys384.H, Ile385.H, Ser388.H | |
| K | -15.0 | Ile381.D, Lys384.D, Ile385.D, Ser388.D, Gly325.H, Ile328.H, Phe329.H, Phe332.H, Pro358.H, Asp359.H, Phe361.H, Trp362.H, Val365.H | |
| L | -12.7 | Leu337.D, Ala341.D, Phe344.D, Ala345.D, Gly382.D, Val386.D, Leu389.D, Ile294.H, Phe301.H | |
| M | -12.6 | Ile294.B, Phe301.B, Leu337.H, Ala341.H, Phe344.H, Ala345.H, Gly382.H, Val386.H, Leu389.H | |
| 4jtd_IC | A | -14.8 | Arg322.D, Leu326.D, Phe329.D, Val170.H, Leu174.H, His306.H, Ser307.H, Lys308.H, Gly309.H |
| C | -13.8 | Leu174.D, His306.D, Ser307.D, Lys308.D, Gly309.D, Arg322.F, Leu326.F, Phe329.F | |
| E | -13.7 | Gln146.F, Val149.F, Ile231.F, Phe235.F, Leu238.F, Val239.F, Phe242.F, Ala243.F | |
| G | -13.7 | Phe145.H, Gln146.H, Val149.H, Ile231.H, Phe235.H, Leu238.H, Val239.H, Phe242.H, Ala243.H | |
| I | -13.6 | Phe145.D, Gln146.D, Val149.D, Ile231.D, Phe235.D, Leu238.D, Val239.D, Phe242.D, Ala243.D | |
| J | -13.8 | Arg322.B, Leu326.B, Phe329.B, Leu174.F, His306.F, Ser307.F, Lys308.F, Gly309.F | |
| K | -13.8 | Leu174.B, His306.B, Ser307.B, Lys308.B, Gly309.B, Arg322.H, Leu326.H, Phe329.H | |
| L | -13.6 | Phe145.B, Gln146.B, Val149.B, Ile231.B, Phe235.B, Leu238.B, Val239.B, Phe242.B, Ala243.B | |
| Kv1.2/Kv2.1 paddle chimera, V406W mutant, rat,5wie | |||
| 5wie_EC | A | -15.3 | Arg287.D, Gln290.D, Ile291.D, Ile294.D, Ala341.F, Ala345.F, Ile385.F, Val386.F, Leu389.F |
| C | -15.2 | Leu337.B, Ala341.B, Ala345.B, Ile385.B, Val386.B, Leu389.B, Arg287.F, Gln290.F, Ile291.F, Ile294.F | |
| E | -13.6 | Ile328.D, Phe329.D, Phe332.D, Pro358.D, Asp359.D, Phe361.D, Trp362.D, Val365.D, Ile381.F, Lys384.F, Ile385.F, Ser388.F | |
| G | -13.4 | Ile381.B, Lys384.B, Ile385.B, Ser388.B, Ile328.F, Phe329.F, Phe332.F, Pro358.F, Asp359.F, Phe361.F, Trp362.F, Val365.F | |
| I | -13.2 | Ser215.H, Thr216.H, Phe218.H, Phe223.H, Thr227.H, Leu238.H, Tyr267.H, Ile270.H | |
| J | -13.2 | Gln214.D, Ser215.D, Thr216.D, Phe218.D, Phe223.D, Leu238.D, Tyr267.D, Ile270.D | |
| K | -13.2 | Ser215.F, Thr216.F, Phe218.F, Phe223.F, Thr227.F, Leu238.F, Tyr267.F, Ile270.F | |
| L | -15.3 | Leu337.D, Ala341.D, Ala345.D, Ile385.D, Val386.D, Leu389.D, Arg287.H, Ile291.H, Ile294.H | |
| M | -15.3 | Arg287.B, Gln290.B, Ile291.B, Ile294.B, Ala341.H, Ala345.H, Ile385.H, Val386.H, Leu389.H | |
| N | -13.6 | Ile328.B, Phe329.B, Phe332.B, Pro358.B, Asp359.B, Phe361.B, Trp362.B, Val365.B, Ile381.H, Lys384.H, Ile385.H, Ser388.H | |
| O | -13.4 | Ile381.D, Lys384.D, Ile385.D, Ser388.D, Ile328.H, Phe329.H, Phe332.H, Pro358.H, Asp359.H, Phe361.H, Trp362.H, Val365.H | |
| P | -13.2 | Ser215.B, Thr216.B, Phe218.B, Phe223.B, Thr227.B, Leu238.B, Tyr267.B, Ile270.B | |
| 5wie_IC | [none] | ||
| Kv1.2/Kv2.1 paddle chimera, in nanodiscs, rat, 6ebk | |||
| 6ebk_EC | A | -15.6 | Arg287.D, Ile291.D, Ile294.D, Leu298.D, Phe301.D, Ala341.F, Ala345.F, Gly382.F, Ile385.F, Val386.F, Leu389.F |
| C | -15.4 | Arg287.B, Ile291.B, Ile294.B, Phe301.B, Ala341.D, Ala345.D, Gly382.D, Ile385.D, Val386.D, Leu389.D | |
| E | -14.1 | Ser215.D, Thr216.D, Ser217.D, Phe218.D, Phe223.D, Thr227.D, Ile231.D, Phe235.D, Leu238.D, Tyr266.D | |
| G | -14.0 | Gln214.H, Ser215.H, Thr216.H, Phe218.H, Phe223.H, Thr227.H, Ile231.H, Leu238.H, Tyr266.H, Tyr267.H, Ile270.H | |
| I | -14.8 | Gln214.F, Ser215.F, Thr216.F, Phe223.F, Thr227.F, Ile231.F, Leu238.F, Tyr266.F, Tyr267.F, Ile270.F | |
| J | -13.2 | Ile328.D, Phe329.D, Phe332.D, Pro358.D, Asp359.D, Phe361.D, Ile381.F, Lys384.F, Ile385.F | |
| K | -13.1 | Ser215.B, Thr216.B, Phe218.B, Phe223.B, Thr227.B, Ile231.B, Leu238.B, Tyr266.B, Tyr267.B, Ile270.B | |
| N | -13.8 | Phe338.B, Ala341.B, Phe344.B, Ala345.B, Gly382.B, Val386.B, Arg287.H, Gln290.H, Ile291.H, Ile294.H | |
| O | -13.4 | Ile381.B, Lys384.B, Ile385.B, Ile328.H, Phe329.H, Phe332.H, Pro358.H, Asp359.H, Phe361.H, Trp362.H | |
| Q | -12.8 | Arg287.F, Ile291.F, Ile294.F, Phe338.H, Ala341.H, Phe344.H, Ala345.H, Gly382.H, Val386.H | |
| R | -13.3 | Ile328.F, Phe329.F, Phe332.F, Pro358.F, Asp359.F, Phe361.F, Ile381.H, Lys384.H, Ile385.H | |
| 6ebk_IC | [none] | ||
| Kv1.2/Kv2.1 paddle chimera, in nanodiscs, TM domain, rat, 6ebm | |||
| 6ebm_EC | A | -14.9 | Arg287.D, Ile291.D, Ile294.D, Phe301.D, Ala341.F, Ala345.F, Gly382.F, Ile385.F, Val386.F, Leu389.F |
| C | -14.4 | Gln214.D, Ser215.D, Thr216.D, Phe223.D, Thr227.D, Ile231.D, Leu238.D, Tyr266.D, Tyr267.D, Ile270.D | |
| E | -14.3 | Gln214.F, Ser215.F, Thr216.F, Phe223.F, Thr227.F, Ile231.F, Leu238.F, Tyr266.F, Tyr267.F, Ile270.F | |
| G | -13.9 | Ser215.B, Thr216.B, Ser217.B, Phe218.B, Phe223.B, Thr227.B, Leu238.B, Tyr266.B, Tyr267.B | |
| I | -13.2 | Ile291.F, Ile294.F, Ala341.H, Phe344.H, Ala345.H, Gly382.H, Ile385.H, Val386.H, Leu389.H | |
| J | -13.1 | Ile328.D, Phe332.D, Pro358.D, Asp359.D, Phe361.D, Ile381.F, Lys384.F, Ile385.F | |
| K | -12.9 | Leu337.B, Ala341.B, Ala345.B, Gly382.B, Val386.B, Arg287.H, Ile291.H, Ile294.H, Leu298.H, Phe301.H | |
| L | -15.4 | Arg287.B, Ile291.B, Ile294.B, Ala341.D, Ala345.D, Gly382.D, Ile385.D, Val386.D, Leu389.D | |
| M | -13.4 | Ser215.H, Thr216.H, Phe218.H, Phe223.H, Thr227.H, Leu228.H, Ile231.H, Trp232.H | |
| N | -13.3 | Ile328.B, Phe329.B, Phe332.B, Pro358.B, Asp359.B, Phe361.B, Ile381.D, Lys384.D, Ile385.D | |
| O | -13.0 | Ile381.B, Lys384.B, Ile385.B, Ser388.B, Leu389.B, Ile328.H, Pro358.H, Asp359.H, Phe361.H, Trp362.H | |
| 6ebm_IC | A | -14.9 | Leu174.B, Leu303.B, Ser307.B, Lys308.B, Gly309.B, Arg322.D, Phe329.D, Phe332.D |
| C | -14.1 | Val170.D, Leu174.D, Leu303.D, His306.D, Ser307.D, Lys308.D, Arg322.F, Ile328.F, Phe329.F, Phe332.F | |
| E | -13.3 | Ile254.F, Leu298.F, Phe301.F, Gly314.F, Gln315.F, Leu317.F, Lys318.F, Met321.F, Leu337.H, Phe338.H, Ala341.H, Val386.H, Leu389.H | |
| G | -13.2 | Ile254.D, Ile294.D, Leu298.D, Phe301.D, Gly314.D, Leu317.D, Lys318.D, Met321.D, Leu337.F, Phe338.F, Ala341.F, Val386.F, Leu389.F | |
| I | -16.0 | Arg322.B, Gly325.B, Leu326.B, Ile328.B, Phe329.B, Ser307.H, Lys308.H, Gly309.H, Leu310.H | |
| J | -14.5 | Met171.F, Leu174.F, Val178.F, Leu303.F, Ser307.F, Arg322.H, Phe329.H, Phe332.H | |
| K | -12.9 | Leu337.B, Phe338.B, Ala341.B, Val386.B, Leu389.B, Ile254.H, Leu298.H, Phe301.H, Gly314.H, Leu317.H, Lys318.H | |
| L | -12.8 | Ile254.B, Leu298.B, Phe301.B, Gly314.B, Gln315.B, Leu317.B, Lys318.B, Leu337.D, Phe338.D, Ala341.D, Val386.D, Leu389.D | |
| Kv7.1 | |||
| Kv 7.1 (KCNQ1) complex with CaM, Xenopus, 5vms | |||
| 5vms_EC | B | -14.1 | Trp313.A, Lys316.A, Thr317.A, Ser320.A, Leu256.C, Phe260.C, Leu293.C, Phe120.E, Ile128.E |
| D | -14.0 | Leu256.A, Phe260.A, Ala290.A, Leu293.A, Phe120.C, Ile128.C, Trp313.G, Lys316.G, Thr317.G, Ser320.G | |
| F | -12.7 | Leu193.E, Ile194.E, Val197.E, Ala198.E, Ile201.E, Val202.E, Arg218.E, Gly219.E | |
| H | -12.6 | Leu193.C, Ile194.C, Val197.C, Ala198.C, Ile201.C, Val202.C, Arg218.C, Gly219.C | |
| I | -12.6 | Leu193.A, Ile194.A, Val197.A, Ala198.A, Ile201.A, Val202.A, Arg218.A, Gly219.A | |
| J | -12.1 | Ile151.C, Val155.C, Gly158.C, Val162.C, Val200.C, Leu203.C, Cys204.C, Gly206.C | |
| K | -11.9 | Ile151.E, Val155.E, Gly158.E, Ala159.E, Val162.E, Val200.E, Leu203.E, Cys204.E | |
| L | -14.1 | Trp313.C, Lys316.C, Thr317.C, Ser320.C, Leu256.E, Phe260.E, Ala290.E, Leu293.E, Trp294.E, Phe120.G, Ile128.G | |
| M | -14.0 | Phe120.A, Ile128.A, Trp313.E, Ile314.E, Lys316.E, Thr317.E, Ser320.E, Leu256.G, Phe260.G, Leu293.G | |
| N | -12.5 | Leu193.G, Ile194.G, Val197.G, Ala198.G, Ile201.G, Val202.G, Arg218.G, Gly219.G | |
| O | -12.1 | Ile151.G, Val155.G, Gly158.G, Val162.G, Val200.G, Leu203.G, Cys204.G, Gly206.G | |
| P | -11.9 | Ile151.A, Val155.A, Gly158.A, Ala159.A, Val162.A, Val200.A, Leu203.A, Cys204.A | |
| 5vms_IC | B | -14.5 | Tyr161.E, Leu165.E, Val177.E, Arg180.E, Leu181.E, Ala184.E, Leu193.E, Val200.E |
| D | -14.5 | Tyr161.C, Leu165.C, Val177.C, Arg180.C, Leu181.C, Ala184.C, Leu193.C, Val200.C | |
| F | -14.4 | Tyr161.A, Leu165.A, Val177.A, Arg180.A, Leu181.A, Ala184.A, Leu193.A, Val200.A | |
| H | -14.5 | Tyr161.G, Leu165.G, Val177.G, Arg180.G, Leu181.G, Ala184.G, Leu193.G, Val200.G | |
| Kv 7.1 (KCNQ1) complex with CaM, human, 6uzz | |||
| 6uzz_EC | B | -14.8 | Phe127.C, Phe130.C, Leu134.C, Phe270.E, Leu273.E, Ala300.E, Asp301.E, Leu303.E, Trp304.E, Val307.E, Thr327.G |
| D | -14.8 | Thr327.A, Phe127.E, Phe130.E, Leu134.E, Phe270.G, Leu273.G, Ala300.G, Leu303.G, Trp304.G, Val307.G | |
| F | -14.8 | Phe270.A, Leu273.A, Ala300.A, Leu303.A, Trp304.A, Val307.A, Thr327.C, Phe127.G, Phe130.G, Leu134.G | |
| H | -14.1 | Phe157.G, Ile161.G, Val164.G, Val165.G, Gly168.G, Thr169.G, Val172.G, Met210.G, Leu213.G, Cys214.G, Ser217.G | |
| I | -14.0 | Phe157.E, Ile161.E, Val164.E, Val165.E, Gly168.E, Thr169.E, Val172.E, Met210.E, Leu213.E, Cys214.E, Ser217.E | |
| J | -13.7 | Ile200.E, Leu203.E, Ile204.E, Val207.E, Ala208.E, Val211.E, Val212.E, Ser225.E, Ala226.E, Arg228.E, Gly229.E | |
| K | -13.6 | Ile200.G, Ile204.G, Val207.G, Ala208.G, Val211.G, Val212.G, Ser225.G, Ala226.G, Arg228.G, Gly229.G | |
| L | -14.4 | Leu134.A, Leu266.C, Tyr267.C, Phe270.C, Leu303.C, Val307.C, Trp323.E, Lys326.E, Thr327.E, Ser330.E | |
| M | -14.1 | Phe157.C, Ile161.C, Val164.C, Val165.C, Gly168.C, Thr169.C, Val172.C, Met210.C, Leu213.C, Cys214.C, Ser217.C | |
| N | -14.0 | Phe157.A, Ile161.A, Val164.A, Val165.A, Gly168.A, Thr169.A, Val172.A, Met210.A, Leu213.A, Cys214.A, Ser217.A | |
| O | -13.7 | Ile200.A, Ile204.A, Val207.A, Ala208.A, Val211.A, Val212.A, Ser225.A, Ala226.A, Gly229.A | |
| P | -13.6 | Ile200.C, Leu203.C, Ile204.C, Val207.C, Ala208.C, Val211.C, Val212.C, Ser225.C, Ala226.C, Arg228.C, Gly229.C | |
| 6uzz_IC | B | -14.6 | Pro117.E, Phe123.E, His126.E, Phe130.E, Val241.E, Asp242.E, Arg243.E, Tyr267.G, Phe270.G |
| D | -14.1 | Tyr267.A, Phe270.A, Pro117.G, Thr118.G, Phe123.G, His126.G, Phe130.G, Val241.G, Asp242.G, Arg243.G | |
| F | -13.8 | Phe275.A, Phe279.A, Pro197.G, Ile198.G, Ile201.G, Phe232.G, Leu239.G, Gly245.G, Trp248.G, Arg249.G | |
| H | -13.8 | Pro117.C, Phe123.C, His126.C, Phe130.C, Val241.C, Ile263.E, Tyr267.E, Phe270.E | |
| I | -13.7 | Pro197.E, Ile198.E, Ile201.E, Phe232.E, Leu239.E, Gly245.E, Trp248.E, Arg249.E, Phe275.G, Phe279.G | |
| J | -13.6 | Trp248.E, Leu251.E, Gly252.E, Val255.E, Phe256.E, Gly272.G, Phe275.G, Ser276.G, Phe332.G, Ala336.G, Phe339.G | |
| K | -13.6 | Gly272.A, Phe275.A, Ser276.A, Trp248.G, Gly252.G, Ser253.G, Val255.G, Phe256.G | |
| L | -14.6 | Pro117.A, Thr118.A, Phe123.A, His126.A, Phe130.A, Val241.A, Asp242.A, Arg243.A, Tyr267.C, Phe270.C | |
| M | -13.8 | Lys196.C, Pro197.C, Ile198.C, Ile201.C, Phe232.C, Leu239.C, Gly245.C, Trp248.C, Arg249.C, Phe275.E, Phe279.E | |
| N | -13.8 | Pro197.A, Ile198.A, Ile201.A, Phe232.A, Leu236.A, Leu239.A, Gln244.A, Gly245.A, Trp248.A, Arg249.A, Phe275.C | |
| O | -13.6 | Trp248.A, Leu251.A, Gly252.A, Ser253.A, Val255.A, Phe256.A, Gly272.C, Phe275.C, Ser276.C, Phe332.C, Ala336.C, | |
| P | -13.0 | Trp248.C, Leu251.C, Gly252.C, Val255.C, Phe256.C, Gly272.E, Phe275.E, Phe279.E, Phe339.E | |
| Kv 7.1 (KCNQ1) complex with CaM and KCNE3, human, 6v00 | |||
| 6v00_EC | B | -15.2 | Ile200.J, Ile204.J, Val207.J, Ala208.J, Val211.J, Val212.J, Ser225.J, Arg228.J, Gly229.J |
| E | -15.1 | Ile200.A, Ile204.A, Val207.A, Ala208.A, Val211.A, Val212.A, Ser225.A, Arg228.A, Gly229.A, Phe232.A | |
| H | -13.4 | Phe157.A, Ile161.A, Val165.A, Gly168.A, Thr169.A, Val172.A, Met210.A, Leu213.A, Cys214.A, Ser217.A | |
| K | -13.3 | Phe157.J, Ile161.J, Val165.J, Gly168.J, Thr169.J, Val172.J, Met210.J, Leu213.J, Cys214.J, Ser217.J | |
| M | -15.2 | Ile200.G, Ile204.G, Val207.G, Ala208.G, Val211.G, Val212.G, Ser225.G, Arg228.G, Gly229.G, Phe232.G | |
| N | -15.0 | Ile204.D, Ala208.D, Val212.D, Ser225.D, Arg228.D, Gly229.D, Phe232.D, Leu233.D | |
| O | -13.2 | Phe157.G, Ile161.G, Val164.G, Val165.G, Gly168.G, Thr169.G, Val172.G, Met210.G, Leu213.G, Cys214.G, Ser217.G, Lys218.G | |
| P | -13.2 | Phe157.D, Ile161.D, Val165.D, Gly168.D, Thr169.D, Val172.D, Met210.D, Leu213.D, Cys214.D, Ser217.D | |
| 6v00_IC | B | -15.4 | Pro197.A, Ile198.A, Ile201.A, Leu239.A, Gln244.A, Gly245.A, Trp248.A, Arg249.A |
| E | -15.2 | Pro197.J, Ile198.J, Ile201.J, Leu239.J, Gln244.J, Gly245.J, Gly246.J, Trp248.J, Arg249.J | |
| H | -13.7 | Trp248.A, Leu251.A, Gly252.A, Val255.A, Gly272.D, Phe275.D, Ser276.D, Phe332.D | |
| K | -13.7 | Gly272.A, Phe332.A, Phe335.A, Ala336.A, Phe339.A, Trp248.J, Leu251.J, Gly252.J | |
| M | -13.5 | Val255.A, Phe256.A, Arg259.A, Ile263.A, Cys331.D, Phe335.D, Phe63.L, Val70.L, Ser74.L, Leu77.L | |
| N | -12.9 | Cys331.A, Phe335.A, Val70.I, Ser74.I, Leu77.I, Val255.J, Phe256.J, Arg259.J, Ile263.J | |
| O | -13.1 | Phe127.J, Leu131.J, Phe66.L, Ala69.L, Val70.L, Gly73.L, Ser74.L, Leu77.L, Arg81.L | |
| P | -13.1 | Phe123.G, Phe127.G, Leu131.G, Phe66.I, Ala69.I, Val70.I, Gly73.I, Ser74.I, Leu77.I, Arg81.I | |
| Q | -15.1 | Pro197.G, Ile198.G, Ile201.G, Leu239.G, Gln244.G, Gly245.G, Trp248.G, Arg249.G | |
| R | -14.8 | Pro197.D, Ile198.D, Ile201.D, Leu239.D, Gln244.D, Gly245.D, Trp248.D, Arg249.D | |
| S | -12.6 | Phe123.A, Phe127.A, Leu131.A, Phe66.C, Val70.C, Gly73.C, Leu77.C, Arg81.C | |
| T | -14.0 | Trp248.D, Leu251.D, Gly252.D, Ser253.D, Val255.D, Phe256.D, Phe279.G, Cys331.G, Phe335.G | |
| U | -13.9 | Trp248.G, Leu251.G, Gly252.G, Val255.G, Phe256.G, Phe279.J, Cys331.J, Phe335.J | |
| V | -13.3 | Phe63.C, Phe66.C, Leu67.C, Val70.C, Leu77.C, Arg81.C, Cys331.G, Phe335.G | |
| W | -13.2 | Phe63.F, Phe66.F, Leu67.F, Val70.F, Ser74.F, Leu77.F, Arg81.F, Cys331.J, Phe335.J | |
| Kv 7.1 (KCNQ1) complex with CaM, KCNE3 and PIP2, human, 6v01 | |||
| 6v01_EC | B | -13.2 | Ile200.J, Ile204.J, Ala208.J, Val212.J, Ser225.J, Arg228.J, Gly229.J, Phe232.J, Leu233.J |
| E | -12.9 | Ile200.A, Ile204.A, Ala208.A, Val212.A, Arg228.A, Gly229.A, Phe232.A, Leu233.A | |
| H | -12.8 | Ile200.D, Ile204.D, Ala208.D, Ser225.D, Arg228.D, Gly229.D, Phe232.D, Leu233.D | |
| 6v01_IC | B | -14.2 | Arg192.A, Arg195.A, Pro197.A, Ile200.A, Ile201.A, Ile204.A, Phe232.A, Leu233.A, Leu236.A |
| E | -13.9 | Arg192.J, Arg195.J, Pro197.J, Ile200.J, Ile201.J, Ile204.J, Phe232.J, Leu233.J, Leu236.J | |
| H | -13.5 | Trp248.A, Arg249.A, Leu251.A, Gly252.A, Thr327.D, Cys331.D, Phe335.D, Phe63.L | |
| K | -13.3 | Trp248.G, Arg249.G, Leu251.G, Gly252.G, Phe279.J, Ile328.J, Cys331.J, Phe335.J | |
| M | -14.8 | Pro197.A, Ile198.A, Ile201.A, Leu239.A, Gly245.A, Trp248.A, Phe275.D, Ser276.D, Phe279.D, Cys331.D, Phe332.D | |
| N | -13.4 | Leu191.J, Arg192.J, Arg195.J, Ile200.J, Leu203.J, Ile204.J, Val207.J, Ala208.J, Val211.J | |
| O | -13.3 | Thr327.A, Cys331.A, Phe335.A, Phe63.I, Phe66.I, Leu67.I, Trp248.J, Leu251.J, Gly252.J | |
| P | -14.4 | Ser276.A, Phe279.A, Cys331.A, Pro197.J, Ile198.J, Ile201.J, Leu239.J, Gly245.J, Trp248.J | |
| Q | -13.9 | Tyr171.J, Leu175.J, Arg190.J, Leu191.J, Phe193.J, Ala194.J, Leu203.J, Val207.J | |
| R | -13.2 | Leu191.A, Arg192.A, Arg195.A, Ile200.A, Leu203.A, Ile204.A, Val207.A, Ala208.A, Val211.A | |
| S | -14.7 | Pro197.D, Ile201.D, Leu239.D, Trp248.D, Phe275.G, Ser276.G, Phe279.G, Ile328.G, Cys331.G | |
| T | -13.5 | Leu175.G, Leu187.G, Arg190.G, Leu191.G, Ala194.G, Leu203.G, Val207.G, Val211.G | |
| U | -14.2 | Arg195.D, Pro197.D, Ile200.D, Ile201.D, Ile204.D, Phe232.D, Leu233.D, Leu236.D | |
| V | -13.5 | Arg192.G, Arg195.G, Pro197.G, Ile200.G, Ile201.G, Ile204.G, Phe232.G, Leu233.G, Leu236.G | |
| W | -14.5 | Pro197.G, Ile201.G, Phe232.G, Leu239.G, Gly245.G, Trp248.G, Arg249.G, Phe279.J | |
| X | -13.8 | Leu191.G, Arg192.G, Ala194.G, Arg195.G, Ile200.G, Leu203.G, Ile204.G, Val211.G | |
| Y | -13.8 | Leu191.D, Arg192.D, Ala194.D, Arg195.D, Ile200.D, Leu203.D, Ile204.D, Val211.D | |
| Z | -13.3 | Phe63.C, Trp248.D, Arg249.D, Leu251.D, Gly252.D, Thr327.G, Cys331.G, Phe335.G | |
| a | -13.1 | Tyr171.D, Leu175.D, Arg190.D, Leu191.D, Ala194.D, Leu203.D, Val207.D, Met210.D, Val211.D | |
| Kv10.1 | |||
| Kv10.1 (Eag1), plus calmodulin, rat, 5k71 | |||
| 5k71_EC | B | -14.1 | Pro236.C, Val239.C, Ser240.C, Val328.C, Leu331.C, Trp365.C, Cys368.C, Ile369.C, Ser372.C |
| D | -14.1 | Pro236.E, Val239.E, Ser240.E, Val328.E, Leu331.E, Trp365.E, Cys368.E, Ile369.E, Ser372.E | |
| F | -14.1 | Pro236.A, Val239.A, Ser240.A, Val328.A, Leu331.A, Trp365.A, Cys368.A, Ile369.A, Ser372.A | |
| H | -14.1 | Pro236.G, Val239.G, Ser240.G, Val328.G, Leu331.G, Trp365.G, Cys368.G, Ile369.G, Ser372.G, Ile373.G | |
| 5k71_IC | B | -13.9 | Leu262.C, Phe269.C, Lys285.C, Arg288.C, Phe296.C, Leu300.C, Leu304.C, Pro305.C, Ile309.C |
| D | -13.8 | Leu262.E, Phe269.E, Lys285.E, Arg288.E, Phe296.E, Leu300.E, Leu304.E, Pro305.E, Ile309.E | |
| F | -12.9 | His208.E, Ile209.E, Ile210.E, Val259.E, Val263.E, Val266.E, Leu267.E, His270.E | |
| H | -12.8 | His208.C, Ile209.C, Ile210.C, Val259.C, Val263.C, Val266.C, Leu267.C, His270.C | |
| I | -12.8 | His208.A, Ile209.A, Ile210.A, Val259.A, Val263.A, Val266.A, Leu267.A, His270.A | |
| J | -13.9 | Leu262.G, Phe269.G, Lys285.G, Arg288.G, Phe296.G, Leu300.G, Leu304.G, Pro305.G, Ile309.G | |
| K | -13.9 | Leu262.A, Phe269.A, Lys285.A, Arg288.A, Phe296.A, Leu300.A, Leu304.A, Pro305.A, Ile309.A | |
| L | -12.4 | His208.G, Ile210.G, Val259.G, Leu262.G, Val263.G, Val266.G, Leu267.G, His270.G | |
| Kv10.1 (Eag1), pre-open mutant, conformation 2, human, 6pbx | |||
| 6pbx_EC | B | -13.6 | Ile451.C, Trp222.E, Leu225.E, Ile226.E, Phe229.E, Ile233.E, Cys357.E, His364.E, Tyr423.E, Ile424.E, Leu427.E |
| D | -13.5 | Trp222.G, Leu225.G, Ile226.G, Phe229.G, Ile233.G, Cys357.G, His364.G, Tyr423.G, Ile424.G, Leu427.G | |
| F | -12.4 | Ile451.C, Ala455.C, Met458.C, Ile459.C, Leu462.C, Leu352.E, Val353.E, Val356.E | |
| H | -12.4 | Ile451.E, Val454.E, Ala455.E, Met458.E, Ile459.E, Leu462.E, Leu352.G, Val353.G, Val356.G | |
| I | -13.6 | Trp222.A, Leu225.A, Ile226.A, Phe229.A, Ile233.A, Cys357.A, His364.A, Tyr423.A, Leu427.A | |
| J | -13.5 | Ile451.A, Trp222.C, Leu225.C, Ile226.C, Phe229.C, Ile233.C, Cys357.C, His364.C, Tyr423.C, Ile424.C, Leu427.C | |
| K | -12.5 | Ile451.A, Ala455.A, Met458.A, Ile459.A, Leu462.A, Leu352.C, Val353.C, Val356.C | |
| 6pbx_IC | B | -13.9 | Trp222.G, Leu225.G, Ile226.G, Phe229.G, Ile233.G, Tyr344.G, Tyr347.G, Ala350.G, Val353.G, Cys357.G |
| D | -13.6 | Trp222.E, Ile226.E, Phe229.E, Ile233.E, Tyr347.E, Ala350.E, Val353.E, Cys357.E | |
| F | -13.4 | Phe475.A, Met478.A, Tyr479.A, Leu341.G, Ile345.G, Val351.G, Leu355.G, Val358.G, Ala362.G, Trp365.G, Met366.G, Ile459.G, Leu463.G, Thr466.G | |
| H | -13.4 | Leu341.C, Ile345.C, Val351.C, Leu355.C, Val358.C, Ala362.C, Trp365.C, Met366.C, Ile459.C, Leu463.C, Thr466.C, Phe475.E, Met478.E, Tyr479.E | |
| I | -13.3 | Leu341.E, Ile345.E, Val351.E, Leu355.E, Val358.E, Ala362.E, Trp365.E, Met366.E, Ile459.E, Leu463.E, Thr466.E, Phe475.G, Met478.G, Tyr479.G | |
| J | -13.8 | Trp222.A, Leu225.A, Ile226.A, Phe229.A, Ile233.A, Tyr344.A, Tyr347.A, Ala350.A, Val353.A, Cys357.A | |
| K | -13.8 | Trp222.C, Leu225.C, Ile226.C, Phe229.C, Ile233.C, Tyr344.C, Tyr347.C, Ala350.C, Val353.C, Cys357.C | |
| L | -13.3 | Leu341.A, Ile345.A, Val351.A, Leu355.A, Val358.A, Ala362.A, Trp365.A, Met366.A, Ile459.A, Leu463.A, Thr466.A, Phe475.C, Met478.C, Tyr479.C | |
| Kv10.1 (Eag1), pre-open mutant, conformation 1, human, 6pby | |||
| 6pby_EC | B | -12.5 | Leu251.A, Asp254.A, Ser255.A, Asp258.A, Val259.A, Leu262.A, Phe323.A, Lys327.A, Arg330.A |
| D | -12.5 | Leu251.G, Asp254.G, Ser255.G, Asp258.G, Val259.G, Leu262.G, Phe323.G, Lys327.G, Arg330.G | |
| F | -12.3 | Ile451.E, Val454.E, Ala455.E, Met458.E, Leu462.E, Leu352.G, Val353.G, Val356.G, Gly360.G, Leu427.G | |
| H | -12.3 | Leu352.A, Val353.A, Val356.A, Gly360.A, Tyr423.A, Leu427.A, Ile451.G, Val454.G, Ala455.G, Met458.G, Leu462.G | |
| I | -11.9 | Trp222.G, Ile226.G, Phe229.G, Tyr230.G, Ile233.G, Leu234.G, Tyr237.G, Trp250.G | |
| J | -12.6 | Trp222.A, Ile226.A, Phe229.A, Tyr230.A, Ile233.A, Leu234.A, Tyr237.A, Trp250.A | |
| 6pby_IC | B | -13.4 | Asp258.G, Leu262.G, Ile265.G, Val266.G, Phe269.G, Arg288.G, Phe296.G, Leu300.G |
| D | -13.4 | Asp258.C, Leu262.C, Ile265.C, Val266.C, Phe269.C, Arg288.C, Phe296.C, Leu300.C | |
| F | -13.0 | Asp258.E, Leu262.E, Ile265.E, Val266.E, Phe269.E, Arg288.E, Phe296.E, Leu300.E, Cys303.E | |
| H | -12.7 | Trp295.A, Ile298.A, Leu331.A, Leu332.A, Leu334.A, Gly335.A, Ala338.A, Leu341.A, Trp365.A | |
| I | -12.7 | Trp295.G, Ile298.G, Leu331.G, Leu332.G, Leu334.G, Gly335.G, Ala338.G, Leu341.G, Trp365.G | |
| J | -12.6 | Trp295.E, Ile298.E, Leu331.E, Leu332.E, Leu334.E, Gly335.E, Ala338.E, Leu341.E, Trp365.E | |
| K | -13.1 | Asp258.A, Leu262.A, Ile265.A, Val266.A, Phe269.A, Arg288.A, Phe296.A, Leu300.A, Cys303.A | |
| L | -12.7 | Trp295.C, Ile298.C, Leu331.C, Leu332.C, Leu334.C, Gly335.C, Ala338.C, Leu341.C, Trp365.C | |
| Kv11.1 | |||
| Kv11.1 (hERG), deletion mutant, human, 5va1 | |||
| 5va1_EC | E | -13.0 | Ile639.B, Ile642.B, Cys643.B, Leu646.B, Leu550.C, Phe551.C, Met554.C, Ala558.C, Tyr611.C, Val612.C, Leu615.C |
| F | -12.9 | Ile639.C, Ile642.C, Cys643.C, Leu646.C, Leu550.D, Phe551.D, Met554.D, Tyr611.D, Val612.D, Leu615.D | |
| G | -12.6 | Ile464.C, Ile467.C, Ala505.C, Ile506.C, Pro507.C, Phe508.C, Asp509.C, Leu510.C | |
| H | -12.5 | Leu457.B, Asp460.B, Ile461.B, Ile464.B, Val465.B, Pro507.B, Phe508.B, Asp509.B | |
| I | -13.9 | Leu457.C, Ile461.C, Ile464.C, Val465.C, Leu468.C, Pro507.C, Phe508.C, Asp509.C | |
| J | -12.5 | Ile467.D, Phe498.D, Met502.D, Ala505.D, Ile506.D, Pro507.D, Phe508.D, Asp509.D, Leu510.D | |
| K | -12.9 | Leu550.A, Phe551.A, Met554.A, Cys555.A, Ala558.A, Tyr611.A, Val612.A, Leu615.A, Ile639.D, Ile642.D, Cys643.D, Leu646.D | |
| L | -12.8 | Ile639.A, Ile642.A, Cys643.A, Leu646.A, Leu550.B, Phe551.B, Met554.B, Cys555.B, Ala558.B, Tyr611.B, Val612.B, Leu615.B | |
| M | -12.7 | Leu457.A, Asp460.A, Ile461.A, Ile464.A, Val465.A, Leu468.A, Pro507.A, Asp509.A | |
| N | -12.4 | Ile467.A, Phe498.A, Met502.A, Ala505.A, Ile506.A, Pro507.A, Phe508.A, Asp509.A, Leu510.A | |
| O | -13.9 | Ile464.B, Ile467.B, Leu468.B, Ala505.B, Ile506.B, Pro507.B, Phe508.B, Asp509.B, Leu510.B | |
| 5va1_IC | F | -14.4 | Leu539.B, Ser543.B, Val549.B, Leu552.B, Leu553.B, Thr556.B, Ile560.B, Trp563.B, Ile647.B, Met651.B, Ile655.B, Asn658.B, Arg665.B, His674.C |
| G | -14.4 | Leu539.C, Ser543.C, Val549.C, Leu552.C, Leu553.C, Thr556.C, Ile560.C, Trp563.C, Ile647.C, Met651.C, Ile655.C, Asn658.C, His674.D | |
| H | -14.3 | His674.A, Leu539.D, Ser543.D, Val549.D, Leu552.D, Leu553.D, Thr556.D, Ile560.D, Trp563.D, Ile647.D, Met651.D, Ile655.D, Asn658.D | |
| J | 14.7 | Leu539.A, Ser543.A, Val549.A, Leu552.A, Leu553.A, Thr556.A, Ile560.A, Trp563.A, Ile647.A, Met651.A, Ile655.A, Asn658.A, His674.B | |
| Kv11.1 (hERG), deletion mutant, human,5va2 | |||
| 5va2_EC | E | -13.4 | Ile639.B, Ile642.B, Cys643.B, Leu646.B, Phe551.C, Met554.C, Ala558.C, Tyr611.C, Val612.C, Leu615.C |
| F | -13.3 | Ile639.C, Ile642.C, Cys643.C, Leu646.C, Phe551.D, Tyr611.D, Val612.D, Leu615.D | |
| G | -12.9 | Pro426.B, Ala429.B, Ala430.B, Leu523.B, Thr526.B, Leu529.B, Trp563.B, Cys566.B, Ile567.B | |
| H | -12.9 | Pro426.C, Ala429.C, Ala430.C, Leu523.C, Thr526.C, Leu529.C, Trp563.C, Cys566.C, Ile567.C | |
| I | -12.8 | Pro426.D, Ala429.D, Ala430.D, Leu523.D, Thr526.D, Leu529.D, Trp563.D, Cys566.D, Ile567.D | |
| J | -12.1 | Ile560.C, Leu564.C, Ile567.C, Ile571.C, Phe640.C, Cys643.C, Ile647.C, Met651.C | |
| K | -12.3 | Leu564.A, Ile567.A, Ile571.A, Ser636.A, Ile639.A, Phe640.A, Cys643.A, Ile647.A | |
| L | -12.4 | Leu564.D, Ile567.D, Ile571.D, Ser636.D, Ile639.D, Phe640.D, Cys643.D, Ile647.D | |
| M | -13.4 | Phe551.A, Met554.A, Tyr611.A, Val612.A, Leu615.A, Ile639.D, Ile642.D, Cys643.D, Leu646.D | |
| N | -13.3 | Ile639.A, Ile642.A, Cys643.A, Leu646.A, Phe551.B, Tyr611.B, Val612.B, Leu615.B | |
| O | -12.9 | Pro426.A, Ala429.A, Ala430.A, Leu523.A, Thr526.A, Leu529.A, Trp563.A, Cys566.A, Ile567.A | |
| P | -12.3 | Ile560.B, Leu564.B, Ile567.B, Ile571.B, Phe640.B, Cys643.B, Ile647.B, Met651.B | |
| 5va2_IC | F | -13.8 | Leu539.C, Ser543.C, Val549.C, Leu553.C, Thr556.C, Ile560.C, Ile647.C, Met651.C, Ile655.C, Asn658.C, His674.D |
| G | -13.3 | Ile663.A, Leu539.D, Leu553.D, Thr556.D, Ile560.D, Trp563.D, Ile647.D, Met651.D, Ser654.D, Asn658.D | |
| H | -13.2 | Leu539.B, Leu553.B, Thr556.B, Ile560.B, Trp563.B, Ile647.B, Met651.B, Ser654.B, Asn658.B, Arg665.B, Ile663.C | |
| I | -13.8 | Leu539.A, Ser543.A, Val549.A, Leu553.A, Thr556.A, Ile560.A, Ile647.A, Met651.A, Ile655.A, Asn658.A | |
| Kv11.1 (hERG), eletion mutant plus S631A mutation, human,5va3 | |||
| 5va3_EC | E | -13.9 | Leu415.D, Leu416.D, Ile419.D, Val423.D, Phe424.D, Tyr427.D, Phe551.D, Leu552.D, Cys555.D, Lys608.D, Tyr611.D |
| F | -13.8 | Leu415.C, Leu416.C, Ile419.C, Val423.C, Phe424.C, Tyr427.C, Phe551.C, Leu552.C, Cys555.C, Lys608.C, Tyr611.C | |
| G | -13.0 | Ile639.C, Ile642.C, Cys643.C, Leu646.C, Leu550.D, Phe551.D, Met554.D, Tyr611.D, Val612.D, Leu615.D | |
| H | -13.5 | Ile639.B, Ile642.B, Cys643.B, Leu646.B, Leu550.C, Phe551.C, Met554.C, Tyr611.C, Val612.C, Leu615.C | |
| I | -13.8 | Leu415.B, Leu416.B, Ile419.B, Val423.B, Phe424.B, Tyr427.B, Phe551.B, Leu552.B, Cys555.B, Lys608.B, Tyr611.B | |
| J | -13.8 | Leu415.A, Leu416.A, Ile419.A, Val423.A, Phe424.A, Tyr427.A, Phe551.A, Leu552.A, Cys555.A, Lys608.A, Tyr611.A | |
| K | -13.0 | Leu550.A, Phe551.A, Met554.A, Tyr611.A, Val612.A, Leu615.A, Ile639.D, Ile642.D, Cys643.D, Leu646.D | |
| L | -13.5 | Ile639.A, Ile642.A, Cys643.A, Leu646.A, Leu550.B, Phe551.B, Met554.B, Tyr611.B, Val612.B, Leu615.B | |
| 5va3_IC | [none] | ||
| Hyperpolarization-activated cyclic nucleotide-gated HCN channels | |||
| HCN1 | |||
| HCN1 apo state, human, 5u6o | |||
| 5u6o_EC | E | -14.4 | Ile151.A, Val154.A, Gly155.A, Val158.A, Trp341.A, Gly342.A, Lys343.A, Tyr345.A, Ser346.A, Met369.B, Trp373.B |
| F | -14.4 | Met369.A, Trp373.A, Ile151.D, Val154.D, Gly155.D, Val158.D, Trp341.D, Gly342.D, Tyr345.D, Ser346.D | |
| G | -14.0 | Ile151.B, Val154.B, Gly155.B, Val158.B, Ile159.B, Trp341.B, Gly342.B, Tyr345.B, Ser346.B, Met369.C, Trp373.C | |
| H | -12.7 | Ile262.B, Leu265.B, Leu268.B, Leu269.B, Leu271.B, Trp311.B, Leu315.B, Leu318.B, Val319.B, Leu322.B | |
| I | -12.7 | Ile262.A, Leu268.A, Leu269.A, Leu271.A, Trp311.A, Leu315.A, Leu318.A, Val319.A, Leu322.A, Leu377.A | |
| J | -14.4 | Ile151.C, Val154.C, Gly155.C, Val158.C, Trp341.C, Gly342.C, Tyr345.C, Ser346.C, Met369.D, Trp373.D | |
| K | -12.7 | Ile262.D, Leu265.D, Leu268.D, Leu269.D, Leu271.D, Trp311.D, Leu315.D, Leu318.D, Val319.D, Leu322.D | |
| L | -12.7 | Ile262.C, Leu268.C, Leu269.C, Leu271.C, Trp311.C, Leu315.C, Leu318.C, Val319.C, Leu322.C, Leu377.C | |
| 5u60_IC | E | -14.7 | Arg297.A, Leu301.A, Met304.A, Leu308.A, Val381.A, Met388.A, His392.A, Leu400.D |
| F | -14.6 | Leu400.A, Arg297.B, Leu301.B, Met304.B, Leu308.B, Val381.B, Met388.B, His392.B | |
| G | -14.4 | Trp133.B, Leu187.B, Ile191.B, Phe194.B, Arg195.B, Phe226.B, Ile230.B, Ile235.B | |
| H | -14.2 | Trp133.A, Leu187.A, Ile191.A, Phe194.A, Arg195.A, Phe226.A, Ile230.A, Ile235.A | |
| I | -13.9 | Val154.D, Val158.D, Leu274.D, Ile278.D, Glu282.D, Phe285.D, Leu291.D, Val296.D, Phe299.D, Gly303.D, Leu306.D, Leu307.D, His310.D | |
| J | -13.9 | Val154.B, Val158.B, Ile278.B, Glu282.B, Phe285.B, Leu291.B, Val296.B, Phe299.B, Gly303.B, Leu306.B, Leu307.B, His310.B | |
| K | -13.9 | Val154.A, Val158.A, Ile278.A, Glu282.A, Phe285.A, Leu291.A, Phe299.A, Gly303.A, Leu306.A, Leu307.A, His310.A | |
| L | -13.6 | Val295.B, Ile298.B, Phe299.B, Ile302.B, Leu306.B, Phe389.B, Leu396.B, Leu400.B, Ile380.C, Thr384.C, Met388.C | |
| M | -14.7 | Leu400.C, Arg297.D, Leu301.D, Met304.D, Leu308.D, Val381.D, Met388.D, His392.D | |
| N | -14.3 | Trp133.D, Leu187.D, Ile191.D, Phe194.D, Arg195.D, Phe222.D, Phe226.D, Ile230.D, Ile235.D | |
| O | -14.3 | Trp133.C, Leu187.C, Ile191.C, Phe194.C, Arg195.C, Phe226.C, Ile230.C, Ile235.C | |
| P | -13.9 | Val154.C, Val158.C, Ile278.C, Glu282.C, Phe285.C, Leu291.C, Val296.C, Phe299.C, Gly303.C, Leu306.C, Leu307.C, His310.C | |
| HCN1, plus cAMP. human, 5u6p | |||
| 5u6p_EC | E | -12.5 | Ile262.A, Leu265.A, Leu269.A, Leu271.A, Trp311.A, Leu315.A, Leu318.A, Val319.A, Leu322.A |
| F | -12.4 | Ile262.B, Leu265.B, Leu269.B, Leu271.B, Trp311.B, Leu315.B, Leu318.B, Val319.B, Leu322.B | |
| G | -12.2 | Val154.A, Val158.A, Gly303.A, Leu306.A, Leu307.A, Tyr345.A, Met369.B, Trp373.B | |
| H | -12.1 | Val154.B, Val158.B, Gly303.B, Leu306.B, Leu307.B, Trp341.B, Tyr345.B, Trp373.C | |
| I | -11.9 | Met369.A, Trp373.A, Val154.D, Val158.D, Gly303.D, Leu306.D, Leu307.D, His310.D, Tyr345.D, Ser346.D | |
| J | -12.5 | Ile262.C, Leu265.C, Leu269.C, Leu271.C, Trp311.C, Leu315.C, Leu318.C, Val319.C, Leu322.C | |
| K | -12.4 | Ile262.D, Leu265.D, Leu269.D, Leu271.D, Trp311.D, Leu315.D, Leu318.D, Val319.D, Leu322.D | |
| L | -12.1 | Val158.C, Gly303.C, Leu306.C, His310.C, Trp341.C, Gly342.C, Tyr345.C, Trp373.D | |
| 5u6p_IC | E | -14.9 | Leu400.A, His279.B, Arg297.B, Leu301.B, Met304.B, Leu308.B, Val381.B, His392.B |
| F | -14.4 | His279.A, Arg297.A, Met304.A, Leu308.A, Val381.A, Met388.A, His392.A, Leu400.D | |
| G | -13.9 | Val154.A, Val158.A, Ile278.A, Glu282.A, Phe285.A, Phe299.A, Asn300.A, Gly303.A, Leu306.A, Leu307.A, His310.A | |
| H | -13.8 | Val154.B, Val158.B, Ile278.B, Glu282.B, Phe285.B, Leu291.B, Val296.B, Asn300.B, Gly303.B, Leu306.B, Leu307.B, His310.B | |
| I | -13.8 | Val154.D, Val158.D, Ile278.D, Glu282.D, Phe285.D, Leu291.D, Phe299.D, Asn300.D, Gly303.D, Leu306.D, Leu307.D, His310.D | |
| J | -13.1 | Leu147.D, Leu150.D, Ile151.D, Val154.D, Gly155.D, Val158.D, Ile159.D, Phe285.D | |
| K | -13.1 | Leu147.A, Leu150.A, Ile151.A, Val154.A, Gly155.A, Val158.A, Ile159.A, Phe285.A | |
| L | -13.0 | Phe98.A, Phe141.A, Trp145.A, Ala181.A, Val185.A, Leu188.A, Met192.A, Arg195.A | |
| M | -12.9 | Phe98.B, Phe141.B, Trp145.B, Ala181.B, Val185.B, Leu188.B, Met192.B, Arg195.B | |
| N | -12.9 | Leu377.A, Ile380.A, Val295.D, Ile298.D, Phe299.D, Ile302.D, Leu396.D, Leu400.D | |
| O | -12.7 | Phe98.D, Phe141.D, Trp145.D, Ala181.D, Val185.D, Leu188.D, Met192.D, Arg195.D | |
| P | -12.9 | Val295.B, Ile298.B, Phe299.B, Ile302.B, Leu396.B, Leu400.B, Leu377.C, Ile380.C | |
| Q | -14.9 | Leu400.C, His279.D, Arg297.D, Leu301.D, Met304.D, Leu308.D, Val381.D, His392.D | |
| R | -13.9 | Val154.C, Val158.C, Ile278.C, Glu282.C, Phe285.C, Leu291.C, Phe299.C, Asn300.C, Gly303.C, Leu306.C, Leu307.C, His310.C | |
| S | -13.1 | Leu400.B, His279.C, Arg297.C, Met304.C, Leu308.C, Val381.C, Met388.C, His392.C | |
| T | -13.1 | Phe98.C, Phe141.C, Trp145.C, Ala181.C, Val185.C, Leu188.C, Met192.C, Arg195.C | |
| U | -13.1 | Leu147.C, Leu150.C, Ile151.C, Val154.C, Gly155.C, Val158.C, Ile159.C, Phe285.C | |
| V | -13.0 | Val295.C, Phe299.C, Ile302.C, Leu396.C, Leu400.C, Leu377.D, Ile380.D, Met388.D | |
| HCN4 | |||
| HCN4, human, 6gyn | |||
| 6gyn_EC | E | -12.4 | Leu271.D, Val274.D, Gly275.D, Ile279.D, Thr292.D, Pro294.D, Trp295.D, Phe298.D |
| F | -12.3 | Leu271.C, Val274.C, Gly275.C, Ile279.C, Thr292.C, Pro294.C, Trp295.C, Phe298.C | |
| G | -12.1 | Ile382.C, Leu385.C, Leu388.C, Leu389.C, Leu391.C, Ser392.C, Leu435.C, Leu438.C, Val439.C, Leu442.C | |
| H | -11.9 | Ile382.D, Leu385.D, Leu389.D, Leu391.D, Ser392.D, Trp431.D, Leu435.D, Val439.D, Leu442.D | |
| I | -12.1 | Ile382.A, Leu385.A, Leu388.A, Leu389.A, Leu391.A, Ser392.A, Trp431.A, Leu435.A, Leu438.A, Val439.A, Leu442.A | |
| J | -12.0 | Ile382.B, Leu385.B, Leu388.B, Leu389.B, Leu391.B, Ser392.B, Leu435.B, Val439.B, Leu442.B | |
| K | -12.3 | Leu271.B, Val274.B, Gly275.B, Ile279.B, Thr292.B, Pro294.B, Trp295.B, Phe298.B | |
| 6gyn_IC | E | -14.1 | His399.D, Arg417.D, Leu421.D, Met424.D, Leu428.D, Leu497.D, Val501.D, Met508.D |
| F | -14.1 | His399.C, Arg417.C, Leu421.C, Met424.C, Leu428.C, Leu497.C, Val501.C, Met508.C | |
| G | -13.4 | Val274.D, Ile278.D, Ile398.D, Glu402.D, Phe405.D, Val419.D, Asn420.D, Gly423.D, Leu426.D, Leu427.D, His430.D | |
| H | -13.4 | Val274.C, Ile278.C, Ile398.C, Glu402.C, Phe405.C, Val419.C, Asn420.C, Gly423.C, Leu426.C, Leu427.C, His430.C | |
| I | -13.3 | Val274.B, Ile278.B, Ile398.B, Glu402.B, Phe405.B, Val419.B, Asn420.B, Gly423.B, Leu426.B, Leu427.B, His430.B | |
| J | -13.0 | Leu307.C, Val311.C, Phe314.C, Lys334.C, Leu338.C, Phe342.C, Phe346.C, Ile350.C, Pro351.C, Ile355.C | |
| K | -12.9 | Leu307.D, Phe314.D, Lys334.D, Leu338.D, Phe342.D, Phe346.D, Ile350.D, Pro351.D, Ile355.D | |
| L | -14.1 | His399.A, Arg417.A, Asn420.A, Leu421.A, Met424.A, Leu428.A, Leu497.A, Val501.A, Met508.A | |
| M | -14.1 | His399.B, Arg417.B, Leu421.B, Met424.B, Leu428.B, Leu497.B, Val501.B, Met508.B | |
| N | -13.4 | Val274.A, Ile278.A, Ile398.A, Glu402.A, Phe405.A, Val419.A, Asn420.A, Gly423.A, Leu426.A, Leu427.A, His430.A | |
| O | -13.0 | Leu307.A, Val311.A, Phe314.A, Lys334.A, Leu338.A, Phe342.A, Phe346.A, Ile350.A, Pro351.A, Ile355.A | |
| P | -12.9 | Leu307.B, Phe314.B, Lys334.B, Leu338.B, Phe342.B, Phe346.B, Ile350.B, Pro351.B, Ile355.B | |
| HCN4 plus cAMP, human, 6gyo | |||
| 6gyo_EC | 1 | -12.3 | Ile382.B, Leu385.B, Leu388.B, Leu389.B, Leu391.B, Ser392.B, Trp431.B, Leu435.B, Leu438.B, Val439.B, Leu442.B |
| 2 | -12.3 | Ile382.D, Leu385.D, Leu388.D, Leu389.D, Leu391.D, Ser392.D, Trp431.D, Leu435.D, Leu438.D, Val439.D, Leu442.D | |
| 6gyo_IC | E | -14.4 | Leu391.A, Ile395.A, His399.A, Arg417.A, Leu421.A, Met424.A, Leu428.A, Met508.A |
| F | -14.4 | Leu391.B, Ile395.B, His399.B, Arg417.B, Leu421.B, Met424.B, Leu428.B, Met508.B | |
| G | -13.2 | Leu307.B, Leu310.B, Val311.B, Phe314.B, Lys334.B, Phe346.B, Ile350.B, Pro351.B, Ile355.B | |
| H | -13.1 | Leu307.A, Leu310.A, Val311.A, Phe314.A, Lys334.A, Phe346.A, Ile350.A, Pro351.A, Ile355.A | |
| I | -13.7 | Trp341.A, Leu385.A, Leu388.A, Leu389.A, Leu391.A, Ser392.A, Ile395.A, His399.A | |
| J | -13.6 | Trp341.B, Leu385.B, Leu388.B, Leu389.B, Leu391.B, Ser392.B, Ile395.B, His399.B | |
| K | -13.1 | Val274.A, Ile278.A, Ile398.A, Trp401.A, Glu402.A, Thr408.A, Val416.A, Val419.A, Asn420.A, Gly423.A, | |
| L | -12.8 | Val274.D, Ile278.D, Ile398.D, Trp401.D, Glu402.D, Thr408.D, Val416.D, Val419.D, Asn420.D, Gly423.D, | |
| M | -12.7 | Ile278.B, Trp401.B, Thr408.B, Leu411.B, Val419.B, Gly423.B, Leu426.B, Leu427.B, His430.B | |
| N | -12.8 | Leu497.A, Ile500.A, Thr504.A, Met508.A, Ile422.D, Leu516.D, Ile517.D, Leu520.D | |
| O | -12.8 | Ile422.A, Leu516.A, Ile517.A, Leu520.A, Arg417.B, Leu497.B, Ile500.B, Thr504.B, Met508.B | |
| P | -14.4 | Leu391.C, Ile395.C, His399.C, Arg417.C, Asn420.C, Leu421.C, Met424.C, Leu428.C, Met508.C | |
| Q | -13.9 | Leu520.C, Leu391.D, Ile395.D, His399.D, Arg417.D, Leu421.D, Met424.D, Leu428.D, Trp431.D, Met508.D | |
| R | -13.1 | Leu307.D, Leu310.D, Val311.D, Phe314.D, Lys334.D, Phe346.D, Ile350.D, Pro351.D, Ile355.D | |
| S | -13.1 | Leu307.C, Leu310.C, Val311.C, Phe314.C, Lys334.C, Phe346.C, Ile350.C, Pro351.C, Ile355.C | |
| T | -13.0 | Val274.C, Ile278.C, Ile398.C, Trp401.C, Glu402.C, Thr408.C, Val416.C, Val419.C, Asn420.C, Gly423.C, | |
| U | -12.8 | Ile422.B, Leu516.B, Ile517.B, Leu520.B, Arg417.C, Leu497.C, Ile500.C, Thr504.C, Met508.C | |
| V | -12.7 | Trp341.D, Val344.D, Leu389.D, Leu391.D, Ser392.D, Ile395.D, Arg396.D, His399.D | |
| Large conductance, voltage- and calcium-gated channels Slo | |||
| Slo1 | |||
| Slo1, Ca2+ bound, aplysia, 5tj6 | |||
| 5tj6_EC | E | -14.2 | Leu143.D, Val147.D, Met150.D, Ile151.D, Phe183.D, Val184.D, Ile186.D, Tyr187.D |
| F | -14.2 | Leu143.B, Val147.B, Met150.B, Ile151.B, Phe183.B, Val184.B, Ile186.B, Tyr187.B | |
| G | -13.5 | Leu108.B, Ala112.B, Ile115.B, Ile116.B, Ile119.B, Thr137.B, Thr138.B, Val141.B, Phe145.B | |
| H | -13.5 | Leu108.D, Ala112.D, Ile115.D, Ile116.D, Ile119.D, Thr137.D, Thr138.D, Val141.D, Phe145.D | |
| I | -13.5 | Val228.B, Val232.B, Trp235.B, Trp264.B, Leu267.B, Phe307.B, Val287.D, Thr291.D, Val294.D, Met298.D | |
| J | -13.5 | Val287.A, Thr291.A, Val294.A, Met298.A, Val228.D, Val232.D, Trp235.D, Trp264.D, Leu267.D, Phe307.D | |
| K | -13.2 | Trp16.D, Leu20.D, Leu170.D, Phe173.D, Phe177.D, Leu195.D, Phe197.D, Leu198.D, Leu201.D, Phe241.D, Leu244.D, | |
| L | -12.9 | Trp16.A, Leu20.A, Leu170.A, Phe173.A, Phe177.A, Leu195.A, Phe197.A, Leu198.A, Leu201.A, Phe241.A, Leu244.A, | |
| M | -14.2 | Leu143.A, Val147.A, Met150.A, Ile151.A, Phe183.A, Val184.A, Ile186.A, Tyr187.A | |
| N | -14.2 | Leu143.C, Val147.C, Met150.C, Ile151.C, Phe183.C, Val184.C, Ile186.C, Tyr187.C | |
| O | -13.5 | Leu108.A, Ala112.A, Ile115.A, Ile116.A, Ile119.A, Thr137.A, Thr138.A, Val141.A, Phe145.A | |
| P | -13.5 | Leu108.C, Ala112.C, Ile115.C, Ile116.C, Ile119.C, Thr137.C, Thr138.C, Val141.C, Phe145.C | |
| Q | -13.5 | Val228.A, Val232.A, Trp235.A, Trp264.A, Leu267.A, Phe307.A, Phe253.C, Val287.C, Thr291.C, Val294.C, Met298.C | |
| R | -13.4 | Phe253.B, Val287.B, Thr291.B, Val294.B, Met298.B, Val228.C, Val232.C, Trp235.C, Trp264.C, Leu267.C, Phe307.C | |
| S | -13.2 | Trp16.C, Leu20.C, Leu170.C, Phe173.C, Phe177.C, Leu195.C, Phe197.C, Leu198.C, Leu201.C, Phe241.C, Leu244.C, | |
| T | -12.9 | Trp16.B, Leu20.B, Leu170.B, Phe173.B, Phe177.B, Leu195.B, Leu198.B, Leu201.B, Phe241.B, Leu244.B, Pro251.B, | |
| 5tj6_IC | E | -15.3 | Ala312.B, Leu315.B, Gly316.B, Arg318.B, Phe197.D, Leu198.D, Leu234.D, Thr237.D, Ala238.D, Phe241.D, Phe292.D, Ile299.D, Phe300.D, Leu303.D |
| F | -15.3 | Phe197.A, Leu198.A, Leu234.A, Thr237.A, Ala238.A, Phe241.A, Phe292.A, Ile299.A, Phe300.A, Leu303.A, Ala312.D, Leu315.D, Gly316.D, Arg318.D | |
| G | -14.8 | Phe197.B, Leu198.B, Leu201.B, Leu234.B, Thr237.B, Ala238.B, Phe241.B, Phe292.B, Ile299.B, Phe300.B, Leu303.B, Ile311.C, Ala312.C, Leu315.C, Gly316.C, Arg318.C | |
| H | -15.3 | Ala312.A, Leu315.A, Gly316.A, Arg318.A, Phe197.C, Leu198.C, Leu234.C, Thr237.C, Ala238.C, Phe241.C, Phe292.C, Ile299.C, Phe300.C, Leu303.C | |
| Slo1, Ca2+ bound, aplysia, 5tji | |||
| 5tji_EC | E | -13.4 | Leu108.B, Ile111.B, Ala112.B, Ile115.B, Ile116.B, Thr137.B, Thr138.B, Val141.B |
| F | -13.3 | Leu108.D, Ile111.D, Ala112.D, Ile115.D, Ile116.D, Thr137.D, Thr138.D, Val141.D | |
| G | -12.8 | Val25.D, Thr26.D, Ser29.D, Gly30.D, Val33.D, Met150.D, Phe153.D, Phe154.D, Trp167.D, Phe183.D, Val184.D, Tyr187.D | |
| H | -12.7 | Thr26.A, Met150.A, Phe153.A, Phe154.A, Trp167.A, Pro180.A, Phe183.A, Val184.A, Tyr187.A | |
| I | -13.3 | Leu108.A, Ile111.A, Ala112.A, Ile115.A, Ile116.A, Thr137.A, Thr138.A, Val141.A | |
| J | -13.3 | Leu108.C, Ile111.C, Ala112.C, Ile115.C, Ile116.C, Thr137.C, Thr138.C, Val141.C | |
| K | -12.9 | Val25.C, Thr26.C, Ser29.C, Gly30.C, Val33.C, Met150.C, Phe153.C, Phe154.C, Trp167.C, Phe183.C, Val184.C, Tyr187.C | |
| L | -12.8 | Val25.B, Thr26.B, Met150.B, Phe153.B, Phe154.B, Trp167.B, Pro180.B, Phe183.B, Val184.B, Tyr187.B | |
| 5tji_IC | E | -13.8 | Thr26.A, Ser29.A, Gly30.A, Val33.A, Tyr37.A, Trp80.A, Met81.A, Thr82.A, Lys85.A, Phe154.A, Phe157.A, Val158.A |
| F | -13.7 | Ser29.D, Val33.D, Trp80.D, Met81.D, Thr82.D, Lys85.D, Phe154.D, Phe157.D, Val158.D | |
| G | -13.8 | Thr26.B, Ser29.B, Gly30.B, Val33.B, Tyr37.B, Trp80.B, Met81.B, Thr82.B, Lys85.B, Phe154.B, Phe157.B, Val158.B | |
| H | -13.6 | Ser29.C, Val33.C, Tyr37.C, Trp80.C, Met81.C, Thr82.C, Lys85.C, Phe154.C, Phe157.C, Val158.C | |
| Slo1, Ca2+-free, closed, human, 6v3g | |||
| 6v3g_EC | E | -15.5 | Trp22.A, Leu26.A, Met30.A, Val184.A, Phe188.A, Trp203.A, Leu206.A, Phe252.A, Leu255.A, Val256.A, Ser259.A, Gly260.A, Asp261.A, Pro262.A, Phe266.A, Leu299.A |
| F | -15.5 | Trp22.B, Leu26.B, Met30.B, Val184.B, Phe188.B, Trp203.B, Leu206.B, Phe252.B, Leu255.B, Val256.B, Ser259.B, Gly260.B, Asp261.B, Pro262.B, Phe266.B, Leu299.B | |
| G | -15.6 | Trp22.D, Leu26.D, Met30.D, Val184.D, Phe188.D, Trp203.D, Leu206.D, Phe252.D, Leu255.D, Val256.D, Ser259.D, Gly260.D, Asp261.D, Pro262.D, Phe266.D, Leu299.D | |
| H | -15.5 | Trp22.C, Leu26.C, Met30.C, Val184.C, Phe188.C, Trp203.C, Leu206.C, Phe252.C, Leu255.C, Val256.C, Ser259.C, Gly260.C, Asp261.C, Pro262.C, Phe266.C, Leu299.C | |
| 6v3g_IC | E | -13.7 | Phe252.B, Leu302.B, Phe303.B, Phe306.B, Gly310.B, Ala313.B, Met314.B, Ser317.B, Tyr318.B |
| F | -13.5 | Phe252.A, Leu302.A, Phe303.A, Phe306.A, Gly310.A, Ala313.A, Met314.A, Ser317.A, Tyr318.A | |
| G | -13.4 | Arg113.C, Val114.C, Val117.C, Leu118.C, Ala121.C, Ile124.C, Gly125.C, Val128.C, Leu224.C | |
| H | -13.3 | Arg113.B, Val117.B, Leu118.B, Ala121.B, Ile124.B, Gly125.B, Val128.B, Leu224.B | |
| I | -13.9 | Arg113.D, Val117.D, Leu118.D, Ala121.D, Leu122.D, Gly125.D, Ile152.D, Phe156.D | |
| J | -13.8 | Phe252.C, Leu302.C, Phe303.C, Phe306.C, Gly310.C, Ala313.C, Met314.C, Ser317.C, Tyr318.C | |
| K | -13.6 | Phe252.D, Leu302.D, Phe303.D, Phe306.D, Gly310.D, Ala313.D, Met314.D, Ser317.D, Tyr318.D | |
| L | -13.9 | Arg113.A, Val114.A, Val117.A, Leu118.A, Ala121.A, Leu122.A, Gly125.A, Phe156.A | |
| Slo1, Ca2+-bound plus β4, open human, 6v22 | |||
| 6v22_EC | I | -14.7 | Leu239.A, Phe242.A, Ile243.A, Trp246.A, Trp275.A, Thr298.D, Leu302.D, Val305.D, Phe306.D, Leu309.D, Phe2033.H, Ile2034.H, Phe2037.H, Cys2038.H |
| J | -14.6 | Thr298.C, Leu302.C, Val305.C, Phe306.C, Leu309.C, Leu239.D, Phe242.D, Ile243.D, Trp246.D, Trp275.D, Phe2033.G, Ile2034.G, Phe2037.G, Cys2038.G | |
| K | -13.9 | Ala24.C, Ser28.C, Thr32.C, Leu161.C, Phe164.C, Trp178.C, Pro191.C, Phe194.C, Val195.C, Tyr198.C, Leu199.C | |
| L | -13.9 | Ala24.D, Ser28.D, Thr32.D, Leu161.D, Phe164.D, Trp178.D, Pro191.D, Phe194.D, Val195.D, Tyr198.D | |
| M | -13.9 | Phe120.D, Ala121.D, Ile124.D, Gly125.D, Val128.D, Ile132.D, Val2029.G, Leu2032.G, Phe2033.G, Gly2036.G, Phe2037.G, Leu2040.G, Ser2041.G | |
| N | -13.8 | Ala121.A, Val128.A, Ile132.A, Val2029.H, Leu2032.H, Phe2033.H, Gly2036.H, Leu2040.H, Ser2041.H | |
| O | -13.6 | Trp22.D, Pro262.D, Trp263.D, Leu299.D, Phe306.D, Phe2023.H, Ile2026.H, Ser2027.H, Val2030.H, Ser2031.H, Ile2034.H, Phe2035.H | |
| P | -13.5 | Trp22.C, Pro262.C, Trp263.C, Leu299.C, Phe306.C, Phe2023.G, Ile2026.G, Ser2027.G, Val2030.G, Ser2031.G, Ile2034.G, Phe2035.G | |
| Q | -14.1 | Leu26.D, Met30.D, Phe33.D, Val184.D, Phe188.D, Trp203.D, Leu206.D, Phe252.D, Leu255.D, Val256.D, Ser259.D, Leu2020.H, Phe2023.H | |
| R | -13.6 | Leu26.C, Met30.C, Phe33.C, Val184.C, Phe188.C, Trp203.C, Leu206.C, Phe252.C, Leu255.C, Val256.C, Ser259.C, Leu2020.G, Phe2023.G | |
| S | -13.3 | Phe144.A, Tyr145.A, Gln151.A, Met154.A, Ala155.A, Val158.A, Phe159.A, Leu162.A | |
| T | -13.2 | Leu118.C, Phe144.C, Tyr145.C, Gln151.C, Ala155.C, Val158.C, Phe159.C, Leu162.C | |
| U | -13.4 | Phe144.A, Tyr145.A, Met154.A, Val158.A, Leu161.A, Leu162.A, Phe194.A, Val197.A | |
| V | -13.3 | Phe144.D, Tyr145.D, Met154.D, Val158.D, Leu161.D, Leu162.D, Phe194.D, Val197.D | |
| W | -12.8 | Val117.D, Leu118.D, Ala121.D, Leu122.D, Phe148.D, Thr149.D, Ile152.D, Phe156.D | |
| X | -13.7 | Phe144.D, Tyr145.D, Gln151.D, Met154.D, Ala155.D, Val158.D, Phe159.D, Leu162.D | |
| Y | -13.4 | Phe144.C, Tyr145.C, Met154.C, Val158.C, Leu161.C, Leu162.C, Phe194.C, Val197.C | |
| Z | -12.9 | Val117.A, Leu118.A, Ala121.A, Leu122.A, Phe148.A, Thr149.A, Ile152.A, Phe156.A | |
| a | -14.7 | Thr298.B, Leu302.B, Val305.B, Phe306.B, Leu309.B, Leu239.C, Phe242.C, Ile243.C, Trp246.C, Trp275.C, Phe2033.F, Ile2034.F, Phe2037.F, Cys2038.F | |
| b | -14.6 | Thr298.A, Leu302.A, Val305.A, Phe306.A, Leu309.A, Leu239.B, Phe242.B, Ile243.B, Trp246.B, Trp275.B, Phe2033.E, Ile2034.E, Phe2037.E, Cys2038.E | |
| c | -13.9 | Ala121.B, Ile124.B, Val128.B, Ile132.B, Val2029.E, Leu2032.E, Phe2033.E, Gly2036.E, Leu2040.E | |
| d | -13.9 | Ala24.A, Ser28.A, Thr32.A, Leu161.A, Phe164.A, Trp178.A, Pro191.A, Phe194.A, Val195.A, Tyr198.A, Leu199.A | |
| e | -13.9 | Ala24.B, Ser28.B, Thr32.B, Leu161.B, Phe164.B, Trp178.B, Pro191.B, Phe194.B, Val195.B, Tyr198.B | |
| f | -13.8 | Ala121.C, Val128.C, Ile132.C, Val2029.F, Leu2032.F, Phe2033.F, Gly2036.F, Leu2040.F, Ser2041.F | |
| g | -13.6 | Trp22.B, Pro262.B, Trp263.B, Leu299.B, Phe306.B, Phe2023.F, Ile2026.F, Ser2027.F, Val2030.F, Ser2031.F, Ile2034.F, Phe2035.F | |
| h | -13.6 | Pro262.A, Trp263.A, Leu299.A, Phe306.A, Phe2023.E, Ile2026.E, Ser2027.E, Val2030.E, Ser2031.E, Ile2034.E, Phe2035.E | |
| i | -14.1 | Leu26.B, Met30.B, Phe33.B, Val184.B, Phe188.B, Trp203.B, Leu206.B, Phe252.B, Leu255.B, Val256.B, Ser259.B, Leu2020.F, Phe2023.F | |
| j | -13.6 | Leu26.A, Met30.A, Phe33.A, Val184.A, Phe188.A, Trp203.A, Leu206.A, Phe252.A, Leu255.A, Val256.A, Ser259.A, Leu2020.E, Phe2023.E | |
| k | -13.3 | Phe144.B, Tyr145.B, Gln151.B, Met154.B, Ala155.B, Val158.B, Phe159.B, Leu162.B | |
| l | -13.0 | Val117.B, Leu118.B, Ala121.B, Leu122.B, Gly125.B, Phe148.B, Thr149.B, Ile152.B, Phe156.B | |
| m | -13.7 | Phe144.B, Tyr145.B, Met154.B, Val158.B, Leu161.B, Leu162.B, Phe194.B, Val197.B | |
| n | -12.9 | Val117.C, Leu118.C, Ala121.C, Leu122.C, Phe148.C, Thr149.C, Ile152.C, Phe156.C | |
| 6v22_IC | I | -14.7 | Met30.C, Val181.C, Val184.C, Phe188.C, Arg329.D, Lys2016.G, Leu2020.G, Phe2023.G, Leu2024.G |
| J | -14.7 | Arg329.A, Met30.D, Val181.D, Val184.D, Phe188.D, Lys2016.H, Leu2020.H, Phe2023.H, Leu2024.H | |
| K | -14.2 | Trp176.C, Val181.C, Phe208.C, Thr248.C, Ala249.C, Phe252.C, Phe303.C, Arg329.D, Lys2016.G | |
| L | -14.2 | Arg329.A, Trp176.D, Val181.D, Phe208.D, Thr248.D, Ala249.D, Phe252.D, Phe303.D, Lys2016.H | |
| M | -14.8 | Met30.A, Phe34.A, Val181.A, Val184.A, Phe188.A, Arg329.B, Lys2016.E, Leu2020.E, Phe2023.E, Leu2024.E | |
| N | -14.8 | Met30.B, Phe34.B, Val181.B, Val184.B, Phe188.B, Arg329.C, Lys2016.F, Leu2020.F, Phe2023.F, Leu2024.F | |
| O | -14.2 | Trp176.A, Val181.A, Phe208.A, Thr248.A, Ala249.A, Phe252.A, Phe303.A, Arg329.B, Lys2016.E | |
| P | -14.2 | Trp176.B, Val181.B, Phe208.B, Thr248.B, Ala249.B, Phe252.B, Phe303.B, Arg329.C, Lys2016.F | |
| Slo1, Ca2+-free plus β4, closed, human, 6v35 | |||
| 6v35_EC | I | -16.6 | Leu26.C, Met30.C, Phe34.C, Phe188.C, Leu206.C, Phe252.C, Leu255.C, Val256.C, Ser259.C, Gly260.C, Pro262.C, Phe266.C, Leu299.C, Leu2024.G |
| J | -16.3 | Leu26.B, Met30.B, Phe34.B, Phe188.B, Leu206.B, Phe252.B, Leu255.B, Val256.B, Ser259.B, Gly260.B, Pro262.B, Phe266.B, Leu299.B, Leu2024.F | |
| K | -16.1 | Ala121.C, Gly125.C, Ile129.C, Ile132.C, Asp147.C, Phe148.C, Ile152.C, Phe156.C | |
| L | -16.1 | Ala121.B, Gly125.B, Ile129.B, Ile132.B, Asp147.B, Thr149.B, Ile152.B, Phe156.B | |
| M | -16.0 | Ala121.D, Gly125.D, Ile129.D, Ile132.D, Asp147.D, Phe148.D, Thr149.D, Ile152.D, Phe156.D | |
| N | -14.2 | Ala24.C, Ser28.C, Thr32.C, Leu161.C, Pro191.C, Phe194.C, Val195.C, Tyr198.C, Leu199.C | |
| O | -14.1 | Ala24.B, Ser28.B, Thr32.B, Leu161.B, Pro191.B, Phe194.B, Val195.B, Tyr198.B, Leu199.B | |
| P | -13.2 | Val128.C, Ile132.C, Val2029.F, Leu2032.F, Phe2033.F, Gly2036.F, Leu2040.F, Leu2044.F, Phe2174.F | |
| Q | -14.0 | Val128.A, Ile132.A, Val2029.H, Leu2032.H, Phe2033.H, Gly2036.H, Leu2040.H, Leu2044.H, Phe2174.H | |
| R | -16.6 | Leu26.D, Met30.D, Phe34.D, Phe188.D, Leu206.D, Phe252.D, Leu255.D, Val256.D, Ser259.D, Gly260.D, Asp261.D, Pro262.D, Phe266.D, Leu299.D, Leu2024.H | |
| S | -16.5 | Leu26.A, Met30.A, Phe34.A, Phe188.A, Leu206.A, Phe252.A, Leu255.A, Val256.A, Ser259.A, Gly260.A, Pro262.A, Phe266.A, Leu299.A, Leu2024.E | |
| T | -16.0 | Ala121.A, Gly125.A, Ile129.A, Ile132.A, Asp147.A, Phe148.A, Ile152.A, Phe156.A | |
| U | -14.5 | Val128.B, Ile132.B, Val2029.E, Leu2032.E, Phe2033.E, Gly2036.E, Leu2040.E, Leu2044.E, Phe2174.E | |
| V | -14.2 | Ala24.A, Ser28.A, Thr32.A, Leu161.A, Pro191.A, Phe194.A, Val195.A, Tyr198.A, Leu199.A | |
| W | -14.1 | Met21.D, Ala24.D, Ser28.D, Thr32.D, Leu161.D, Pro191.D, Phe194.D, Val195.D, Tyr198.D, Leu199.D | |
| 6v35_IC | I | -14.3 | Leu179.B, Val181.B, Val184.B, Leu206.B, Phe208.B, Leu209.B, Phe252.B, Lys2016.F, Arg2019.F, Leu2020.F, Phe2023.F |
| J | -14.2 | Leu179.C, Val181.C, Val184.C, Leu206.C, Phe208.C, Leu209.C, Phe252.C, Lys2016.G, Arg2019.G, Leu2020.G, Phe2023.G | |
| K | -13.8 | Leu302.B, Phe306.B, Arg2019.F, Leu2022.F, Phe2023.F, Ile2026.F, Val2030.F, Ile2034.F | |
| L | -13.6 | Val97.B, Trp100.B, Ala101.B, Leu161.B, Leu162.B, Gly165.B, Leu166.B, Ile169.B | |
| M | -14.0 | Leu302.C, Phe306.C, Arg2019.G, Leu2022.G, Phe2023.G, Ile2026.G, Val2030.G, Ile2034.G | |
| N | -13.7 | Leu302.B, Val305.B, Phe306.B, Leu309.B, Ala313.B, Leu235.C, Leu239.C, Ile243.C, Trp246.C | |
| O | -13.6 | Trp100.B, Ala101.B, Met104.B, Leu115.B, Ala155.B, Phe159.B, Leu162.B, Leu166.B | |
| P | -13.3 | Phe217.C, Leu221.C, Leu227.C, Ser232.C, Val236.C, Ile243.C, Trp275.C, Ile2026.F, Val2030.F, Phe2033.F, Ile2034.F | |
| Q | -13.8 | Leu302.C, Val305.C, Phe306.C, Leu309.C, Ala313.C, Leu235.D, Leu239.D, Ile243.D, Trp246.D | |
| R | -13.6 | Val305.C, Phe217.D, Leu221.D, Leu227.D, Val236.D, Leu239.D, Ile243.D, Trp246.D, Trp275.D, Val278.D | |
| S | -13.3 | Val97.C, Lys98.C, Asp99.C, Trp100.C, Ala101.C, Gly102.C, Leu161.C, Leu162.C, Gly165.C, Leu166.C, Ile169.C | |
| T | -13.2 | Trp100.C, Ala101.C, Met104.C, Leu115.C, Ala155.C, Phe159.C, Leu162.C, Leu166.C | |
| U | -13.0 | Trp100.D, Ala101.D, Met104.D, Leu115.D, Ala155.D, Phe159.D, Leu162.D, Leu166.D | |
| V | -14.3 | Leu179.D, Val181.D, Val184.D, Leu206.D, Phe208.D, Leu209.D, Phe252.D, Lys2016.H, Arg2019.H, Leu2020.H, Phe2023.H | |
| W | -14.1 | Leu179.A, Val181.A, Val184.A, Leu206.A, Phe208.A, Leu209.A, Phe252.A, Lys2016.E, Arg2019.E, Leu2020.E, Phe2023.E | |
| X | -13.7 | Val97.D, Trp100.D, Ala101.D, Leu161.D, Leu162.D, Gly165.D, Leu166.D, Ile169.D | |
| Y | -14.0 | Leu302.A, Phe306.A, Arg2019.E, Leu2022.E, Phe2023.E, Ile2026.E, Val2030.E, Ile2034.E | |
| Z | -13.9 | Leu302.D, Phe306.D, Arg2019.H, Leu2022.H, Phe2023.H, Ile2026.H, Val2030.H, Ile2034.H | |
| a | -13.9 | Phe208.A, Leu209.A, Thr248.A, Ala249.A, Phe252.A, Phe303.A, Phe306.A, Met314.A, Arg2019.E | |
| b | -13.7 | Leu235.A, Leu239.A, Ile243.A, Trp246.A, Leu302.D, Val305.D, Phe306.D, Leu309.D, Ala313.D | |
| c | -13.4 | Leu302.A, Leu227.B, Leu235.B, Val236.B, Leu239.B, Ile243.B, Trp275.B, Phe2033.E | |
| d | -14.4 | Phe131.A, Phe217.A, Leu227.A, Leu235.A, Val236.A, Leu239.A, Ile243.A, Leu247.A, Trp275.A, Phe2033.H | |
| e | -13.1 | Trp100.A, Ala101.A, Met104.A, Leu115.A, Ala155.A, Phe159.A, Leu162.A, Leu166.A | |
| f | -14.1 | Val97.A, Trp100.A, Ala101.A, Leu161.A, Leu162.A, Gly165.A, Leu166.A, Ile169.A | |
| Slo1, Ca2+-bound, open human, 6v38 | |||
| 6v38_EC | E | -15.2 | Trp22.D, Leu26.D, Met30.D, Phe33.D, Phe34.D, Val184.D, Phe188.D, Leu206.D, Phe208.D, Phe252.D, Leu255.D, Val256.D, Ser259.D, Gly260.D, Pro262.D, Leu299.D |
| F | -15.1 | Trp22.A, Leu26.A, Met30.A, Phe33.A, Phe34.A, Val184.A, Phe188.A, Leu206.A, Phe208.A, Phe252.A, Leu255.A, Val256.A, Ser259.A, Gly260.A, Pro262.A, Leu299.A | |
| G | -14.0 | Phe144.A, Tyr145.A, Met154.A, Val158.A, Leu161.A, Phe194.A, Val197.A, Tyr198.A | |
| H | -13.8 | Phe144.B, Tyr145.B, Met154.B, Val158.B, Leu162.B, Phe194.B, Val197.B, Tyr198.B | |
| I | -14.8 | Phe144.D, Tyr145.D, Met154.D, Val158.D, Leu161.D, Phe194.D, Val197.D, Tyr198.D | |
| J | -13.9 | Thr32.A, Leu161.A, Phe164.A, Trp178.A, Phe187.A, Val190.A, Pro191.A, Phe194.A, Tyr198.A | |
| K | -13.4 | Ala24.D, Ser28.D, Thr32.D, Leu161.D, Phe194.D, Val195.D, Tyr198.D, Leu199.D | |
| L | -15.1 | Trp22.B, Leu26.B, Met30.B, Phe33.B, Phe34.B, Val184.B, Phe188.B, Leu206.B, Phe208.B, Phe252.B, Leu255.B, Val256.B, Ser259.B, Leu299.B | |
| M | -15.1 | Trp22.C, Leu26.C, Met30.C, Phe33.C, Phe34.C, Val184.C, Phe188.C, Leu206.C, Phe208.C, Phe252.C, Leu255.C, Val256.C, Ser259.C, Gly260.C, Leu299.C | |
| N | -14.7 | Phe144.C, Tyr145.C, Met154.C, Val158.C, Leu161.C, Phe194.C, Val197.C, Tyr198.C | |
| O | -13.4 | Ala24.B, Ser28.B, Thr32.B, Leu161.B, Phe164.B, Phe194.B, Val195.B, Tyr198.B, Leu199.B | |
| P | -13.7 | Thr32.C, Leu161.C, Phe164.C, Trp178.C, Phe187.C, Val190.C, Pro191.C, Phe194.C, Tyr198.C | |
| 6v38_IC | E | -16.2 | Trp176.A, Leu179.A, Val181.A, Val184.A, Phe188.A, Leu206.A, Leu209.A, Arg329.B |
| F | -15.9 | Arg329.A, Trp176.D, Leu179.D, Val181.D, Val184.D, Phe188.D, Leu206.D, Leu209.D | |
| G | -14.5 | Ile323.A, Ile326.A, Gly327.A, Asn328.A, Phe208.D, Thr245.D, Thr248.D, Ala249.D, Phe252.D, Phe303.D, Gly310.D | |
| H | -14.5 | Phe208.A, Leu209.A, Thr245.A, Thr248.A, Ala249.A, Phe252.A, Phe303.A, Gly310.A, Ile323.B, Glu324.B, Ile326.B, Gly327.B, Asn328.B | |
| I | -13.6 | Phe208.B, Leu209.B, Thr245.B, Thr248.B, Ala249.B, Phe252.B, Phe303.B, Ile323.C, Glu324.C, Ile326.C, Gly327.C, Asn328.C | |
| J | -15.9 | Trp176.B, Leu179.B, Val181.B, Val184.B, Phe188.B, Leu206.B, Leu209.B, Arg329.C | |
| K | -15.2 | Trp176.C, Leu179.C, Glu180.C, Val181.C, Val184.C, Phe188.C, Leu206.C, Leu209.C, Arg329.D | |
| L | -14.0 | Phe208.C, Leu209.C, Thr245.C, Thr248.C, Ala249.C, Phe252.C, Phe303.C, Gly310.C, Ile323.D, Glu324.D, Ile326.D, Gly327.D, Asn328.D | |
| Slo2 | |||
| Slo2.2, open, chicken, 5u70 | |||
| 5u70_EC | E | -12.8 | Leu103.A, Ile110.A, Leu114.A, Leu258.A, Phe262.A, Leu280.A, Phe281.A, Trp304.B |
| F | -12.6 | Leu153.B, Trp156.B, Ala157.B, Ser161.B, Leu164.B, Ile165.B, Ile205.B, Arg211.B | |
| G | -12.6 | Leu103.B, Ile110.B, Leu114.B, Leu258.B, Phe262.B, Leu280.B, Phe281.B, Trp304.C | |
| H | -12.6 | Leu153.A, Trp156.A, Ala157.A, Ser161.A, Leu164.A, Ile165.A, Ile205.A, Arg211.A | |
| I | -12.5 | Leu153.C, Trp156.C, Ala157.C, Ser161.C, Leu164.C, Ile165.C, Ile205.C, Arg211.C | |
| J | -12.2 | Phe97.A, Leu101.A, Leu153.A, Pro154.A, Ala157.A, Val158.A, Ser161.A, Ile165.A | |
| K | -12.2 | Phe97.B, Leu101.B, Leu153.B, Pro154.B, Ala157.B, Val158.B, Ser161.B, Ile165.B | |
| L | -12.2 | Leu104.A, Leu108.A, Val111.A, Leu115.A, Lys152.A, Pro154.A, Leu155.A, Val158.A | |
| M | -11.7 | Leu104.C, Leu108.C, Val111.C, Leu115.C, Lys152.C, Pro154.C, Leu155.C, Val158.C | |
| N | -12.8 | Leu103.C, Ile110.C, Leu114.C, Leu258.C, Phe262.C, Leu280.C, Phe281.C, Trp304.D | |
| O | -12.6 | Trp304.A, Leu103.D, Ile110.D, Leu114.D, Leu258.D, Phe262.D, Leu280.D, Phe281.D | |
| P | -12.6 | Leu153.D, Trp156.D, Ala157.D, Ser161.D, Leu164.D, Ile165.D, Ile205.D, Arg211.D | |
| Q | -12.1 | Phe97.D, Leu101.D, Leu153.D, Pro154.D, Ala157.D, Val158.D, Ser161.D, Ile165.D | |
| R | -12.3 | Phe97.C, Leu101.C, Leu153.C, Pro154.C, Ala157.C, Val158.C, Ser161.C, Ile165.C | |
| S | -12.2 | Leu104.D, Leu108.D, Val111.D, Leu115.D, Lys152.D, Pro154.D, Leu155.D, Val158.D | |
| 5u70_IC | E | -13.0 | Trp332.A, Ile189.B, Phe218.B, Leu219.B, Trp222.B, Leu309.B, Val316.B, Val320.B |
| F | -13.0 | Trp332.B, Ile189.C, Phe218.C, Leu219.C, Trp222.C, Leu309.C, Val316.C, Val320.C | |
| G | -13.4 | Ile254.A, Phe325.A, Leu328.A, Val329.A, Trp332.A, Leu308.B, Ile312.B, Cys315.B, Val319.B | |
| H | -13.0 | Ile189.A, Phe218.A, Leu219.A, Trp222.A, Leu309.A, Val316.A, Val320.A, Trp332.D | |
| I | -12.8 | Ile254.B, Leu258.B, Phe284.B, Phe325.B, Leu328.B, Val329.B, Trp332.B, Cys315.C, Val319.C | |
| J | -13.0 | Trp332.C, Ile189.D, Phe218.D, Leu219.D, Trp222.D, Leu309.D, Val316.D, Val320.D | |
| K | -13.4 | Leu308.A, Ile312.A, Cys315.A, Val319.A, Ile254.D, Phe325.D, Leu328.D, Val329.D, Trp332.D | |
| Slo2.2, closed, chicken, 5u76 | |||
| 5u76_EC | het | -12.0 | Leu153.A, Trp156.A, Ala157.A, Val160.A, Ser161.A, Leu164.A, Ile165.A, Leu168.A, Ile205.A, Arg211.A |
| E | -13.2 | Leu103.A, Leu107.A, Ile110.A, Leu114.A, Ser279.A, Leu280.A, Phe281.A, Trp304.B | |
| F | -12.0 | Leu153.C, Trp156.C, Ala157.C, Val160.C, Ser161.C, Leu164.C, Ile165.C, Leu168.C, Ile205.C, Arg211.C | |
| G | -12.7 | Leu107.B, Ile110.B, Leu114.B, Leu258.B, Phe262.B, Leu280.B, Phe281.B, Phe284.B, Trp304.C | |
| H | -12.0 | Leu153.B, Trp156.B, Ala157.B, Val160.B, Ser161.B, Leu164.B, Ile165.B, Leu168.B, Ile205.B, Arg211.B | |
| 5u76_IC | 1 | -13.4 | Val311.A, Cys315.A, Leu318.A, Val319.A, Pro322.A, Leu323.A, Ile254.D, Leu258.D, Phe284.D, Ile288.D, Phe325.D, Leu328.D |
| 2 | -13.4 | Ile254.B, Leu258.B, Phe284.B, Ile288.B, Phe325.B, Leu328.B, Val311.C, Cys315.C, Leu318.C, Val319.C, Pro322.C, Leu323.C | |
| Two-pore domain K2P channels | |||
| TASK-1 | |||
| K2P, TASK1, closed, human, 6rv2 | |||
| 6rv2_EC | C | -13.9 | Phe80.A, Ala81.A, Phe84.A, Val221.A, Ala222.A, Phe225.A, Val226.A, Phe16.B |
| D | -13.4 | Val13.A, Phe16.A, Leu20.A, Phe80.B, Phe84.B, Pro218.B, Val221.B, Ala222.B, Phe225.B | |
| 6rv2_IC | C | -15.3 | Leu128.A, Arg131.A, Thr134.A, Leu135.A, Val226.A, Asn5.B, Thr8.B, Leu9.B, Ile12.B |
| D | -15.0 | Lys2.A, Asn5.A, Leu128.B, Arg131.B, Ile132.B, Leu135.B, Val226.B, Thr230.B | |
| K2P, TASK1, closed plus inhbitor, 6rv3 | |||
| 6rv3_EC | C | -12.8 | Leu9.A, Ile12.A, Phe16.A, Leu20.A, Phe80.B, Ala81.B, Phe84.B, Ala222.B, Phe225.B, Val226.B |
| D | -12.7 | Phe80.A, Ala81.A, Phe84.A, Val221.A, Ala222.A, Phe225.A, Val226.A, Leu9.B, Ile12.B, Phe16.B, Leu20.B | |
| 6rv3_IC | C | -13.3 | Asn5.A, Leu9.A, Ile12.A, Leu128.B, Arg131.B, Leu135.B, Val226.B, Thr230.B |
| D | -13.2 | Leu128.A, Arg131.A, Thr134.A, Leu135.A, Asn5.B, Leu9.B, Ile12.B, Phe16.B | |
| K2P, TASK1, closed plus inhibitor, 6rv4 | |||
| 6rv4_EC | C | -13.8 | Phe16.A, Phe80.B, Ala81.B, Phe84.B, Val221.B, Ala222.B, Phe225.B, Val226.B |
| D | -12.8 | Phe80.A, Ala81.A, Val221.A, Ala222.A, Phe225.A, Val226.A, Leu9.B, Ile12.B, Phe16.B | |
| 6rv4_IC | C | -16.1 | Asn5.A, Thr8.A, Leu9.A, Ile12.A, Leu128.B, Arg131.B, Leu135.B, Val226.B |
| D | -13.7 | Leu128.A, Arg131.A, Ile132.A, Leu135.A, Val226.A, Thr230.A, Lys2.B, Asn5.B, Leu9.B, Ile12.B, Phe16.B | |
| TRAAK | |||
| K2P, TRAAK, non-conductive, down state, human, 3um7 | |||
| 3um7_EC | C | -13.6 | Leu33.A, Ala37.A, Leu40.A, Val44.A, Leu116.A, Gly117.A, Phe120.A, Pro259.A, Phe263.A |
| D | -12.8 | Cys206.A, Val210.A, Lys225.A, Leu226.A, Ile229.A, Ile233.A, Leu144.B, Ile147.B, Phe148.B, Leu151.B | |
| E | -12.7 | Leu144.A, Ile147.A, Phe148.A, Leu151.A, Cys206.B, Val210.B, Leu211.B, Lys225.B, Leu226.B, Ile229.B, Ile233.B, Phe272.B | |
| F | -12.7 | Leu168.A, Leu172.A, Leu208.A, Phe209.A, Val216.A, Met220.A, Ser254.A, Tyr257.A, Leu260.A, Val261.A, Trp264.A, Leu267.A | |
| G | -12.5 | Val49.B, Leu53.B, Ala141.B, Gly142.B, Leu144.B, Phe145.B, Phe148.B, Val152.B | |
| 3um7_IC | C | -14.9 | Leu168.B, Ser171.B, His174.B, Gly175.B, Leu208.B, Phe209.B, Leu260.B, Phe263.B, Trp264.B, Leu267.B |
| D | -15.8 | Ser29.B, Leu32.B, Leu33.B, Arg167.B, Leu168.B, Leu260.B, Phe263.B, Leu267.B | |
| K2P, TRAAK, down state, human,4i9w | |||
| 4i9w_EC | C | -13.3 | Leu116.A, Gly117.A, Phe120.A, Pro259.A, Trp262.A, Phe263.A, Leu36.B, Leu40.B |
| D | -13.0 | Leu33.A, Ala37.A, Leu40.A, Asp115.B, Leu116.B, Gly117.B, Phe120.B, Pro259.B | |
| E | -12.8 | Leu208.B, Phe209.B, Thr212.B, Val216.B, Met220.B, Tyr257.B, Leu260.B, Trp264.B, Leu267.B | |
| F | -12.4 | Leu144.A, Ile147.A, Phe148.A, Leu151.A, Leu202.B, Cys206.B, Val210.B, Leu211.B, Lys225.B, Leu226.B, Ile229.B, Ile233.B | |
| G | -12.3 | Ile204.B, Leu207.B, Leu208.B, Thr212.B, Phe215.B, Val216.B, Tyr219.B, Met220.B | |
| 4i9w_IC | [none] | ||
| K2P, TRAAK, non-conductive, down state, human,4rue | |||
| 4rue_EC | C | -14.0 | Ala37.A, Leu40.A, Leu41.A, Val44.A, Leu116.B, Gly117.B, Phe120.B, Pro250.B, Gln258.B, Pro259.B, Trp262.B |
| D | -13.3 | Leu116.A, Gly117.A, Phe120.A, Pro259.A, Trp262.A, Phe263.A, Leu40.B, Val44.B | |
| E | -12.1 | Ala141.A, Leu144.A, Phe145.A, Phe148.A, Val152.A, Tyr42.B, Val49.B, Leu53.B | |
| 4rue_IC | E | -13.3 | Val152.A, Leu156.A, Ile159.A, Arg28.B, Thr31.B, Leu35.B, Leu38.B, Tyr42.B, Leu283.B, Val285.B |
| F | -12.5 | Val164.A, Arg167.A, Leu168.A, Ser170.A, Ser171.A, His174.A, Phe263.A, Leu267.A, Leu36.B | |
| G | -12.5 | Ile182.A, Phe183.A, Trp186.A, Val188.A, Leu200.A, Leu203.A, Leu207.A, Leu211.A | |
| H | -13.1 | Ser171.A, His174.A, Gly175.A, His178.A, Phe201.A, Leu208.A, Phe209.A, Leu267.A | |
| K2P, TRAAK, non-conductive, down state, human,4ruf | |||
| 4ruf_EC | C | -13.6 | Ala37.A, Leu40.A, Leu41.A, Val44.A, Leu116.B, Gly117.B, Phe120.B, Gln258.B, Pro259.B |
| D | -13.0 | Leu116.A, Gly117.A, Phe120.A, Gln258.A, Pro259.A, Leu33.B, Leu36.B, Leu40.B, Val44.B | |
| E | -12.6 | Leu168.B, Leu208.B, Phe209.B, Thr212.B, Val216.B, Met220.B, Ser254.B, Ala256.B, Tyr257.B, Leu260.B, Val261.B, Phe263.B, Trp264.B, Leu267.B | |
| F | -12.4 | Ala141.A, Leu144.A, Phe145.A, Phe148.A, Val152.A, Tyr42.B, Val49.B, Leu53.B | |
| G | -12.1 | Leu144.A, Ile147.A, Phe148.A, Leu151.A, Leu202.B, Lys225.B, Leu226.B, Ile229.B, Ile233.B, Phe272.B | |
| 4ruf_IC | C | -15.2 | Gly175.A, Ile176.A, Ile179.A, Glu180.A, Phe183.A, Leu200.A, Leu203.A, Ile204.A, Leu207.A, Leu211.A |
| D | -14.4 | Phe148.A, Leu151.A, Ala198.B, Met199.B, Leu202.B, Val275.B, Thr278.B, Ile279.B, Trp282.B | |
| K2P, TRAAK, conductive, up state, human,4wfe | |||
| 4wfe_EC | C | -13.3 | Leu36.A, Leu40.A, Leu116.B, Gly117.B, Phe120.B, Ala256.B, Pro259.B, Phe263.B |
| D | -12.4 | Leu202.A, Leu203.A, Cys206.A, Val210.A, Lys225.A, Leu226.A, Ile229.A, Ile233.A, Leu144.B, Ile147.B, Phe148.B | |
| 4wfe_IC | C | -13.6 | Ile147.A, Phe148.A, Leu151.A, Leu202.B, Cys206.B, Val210.B, Ile229.B, Ile233.B, Tyr271.B, Val275.B, Thr278.B, Ile279.B |
| D | -13.6 | Leu35.A, Leu38.A, Tyr42.A, Leu283.A, Val286.A, Val152.B, Leu156.B, Ile159.B | |
| E | -14.5 | Ser171.B, Leu172.B, Arg173.B, His174.B, Gly175.B, Ile176.B, Ile204.B, Leu208.B | |
| F | -13.7 | Ser171.A, His174.A, Gly175.A, His178.A, Leu208.A, Phe209.A, Thr212.A, Leu260.A | |
| K2P, TRAAK, non-conductive, down state in K+, human,4wff | |||
| 4wff_EC | C | -13.3 | Leu116.A, Gly117.A, Phe120.A, Pro259.A, Trp262.A, Phe263.A, Leu36.B, Leu40.B |
| D | -12.7 | Leu33.A, Leu36.A, Ala37.A, Leu40.A, Leu116.B, Gly117.B, Phe120.B, Ala256.B, Pro259.B | |
| E | -12.6 | Leu144.A, Ile147.A, Phe148.A, Leu202.B, Cys206.B, Val210.B, Lys225.B, Leu226.B, Ile229.B, Ile233.B | |
| F | -12.4 | Leu208.B, Phe209.B, Val216.B, Met220.B, Tyr257.B, Leu260.B, Trp264.B, Leu267.B | |
| 4wff_IC | [none] | ||
| K2P, TRAAK, conductive, up state in Tl+, human,4wfg | |||
| 4wfg_EC | C | -13.7 | Ala37.A, Leu40.A, Val44.A, Leu116.B, Gly117.B, Pro250.B, Gln258.B, Pro259.B, Trp262.B |
| D | -13.4 | Leu116.A, Gly117.A, Phe120.A, Pro259.A, Trp262.A, Phe263.A, Leu36.B, Leu40.B | |
| E | -12.9 | Leu144.A, Ile147.A, Phe148.A, Leu202.B, Cys206.B, Val210.B, Leu211.B, Lys225.B, Leu226.B, Ile229.B, Ile233.B, Tyr271.B, Val275.B | |
| F | -12.1 | Ala141.A, Leu144.A, Phe145.A, Phe148.A, Val152.A, Tyr42.B, Val49.B, Leu53.B, Trp282.B, Leu283.B | |
| 4wfg_IC | C | -14.0 | Leu202.A, Val210.A, Ile229.A, Ile233.A, Val275.A, Thr278.A, Ile279.A, Trp282.A, Phe148.B, Leu151.B |
| D | -13.6 | Leu151.A, Leu202.B, Cys206.B, Val210.B, Ile233.B, Val275.B, Thr278.B, Ile279.B, Asn281.B, Trp282.B | |
| K2P, TRAAK, non-conductive, down state in Tl+, human,4wfh | |||
| 4wfh_EC | 1 | -12.4 | Ala37.A, Leu40.A, Val44.A, Leu116.B, Gly117.B, Phe120.B, Pro255.B, Pro259.B |
| 4wfh_IC | C | -14.0 | Ser171.A, Leu172.A, His174.A, Gly175.A, His178.A, Ile204.A, Leu208.A, Phe209.A, Leu267.A |
| D | -13.8 | Ser171.B, Leu172.B, His174.B, Gly175.B, Leu208.B, Phe209.B, Leu260.B, Phe263.B, Trp264.B, Leu267.B | |
| E | -13.4 | Leu202.A, Val275.A, Thr278.A, Ile279.A, Asn281.A, Trp282.A, Phe148.B, Leu151.B | |
| K2P, TRAAK, mouse, 6pis | |||
| 6pis_EC | C | -12.9 | Leu169.A, Leu209.A, Phe210.A, Thr213.A, Val217.A, Leu261.A, Trp265.A, Phe268.A |
| C | -12.5 | Leu117.A, Gly118.A, Phe121.A, Trp263.A, Phe264.A, Leu36.B, Leu40.B, Val44.B | |
| E | -12.3 | Leu203.A, Leu204.A, Cys207.A, Val211.A, Leu227.A, Ile230.A, Ile234.A, Tyr272.A, Val276.A, Leu145.B, Ile148.B, Phe149.B | |
| F | -12.2 | Tyr42.A, Val49.A, Leu53.A, Ala142.B, Leu145.B, Phe146.B, Phe149.B, Val153.B | |
| G | -12.1 | Ala37.A, Leu40.A, Val44.A, Asn116.B, Leu117.B, Gly118.B, Phe121.B, Trp263.B | |
| 6pis_IC | 1 | -14.7 | Leu169.B, Ser172.B, Leu173.B, Gly176.B, Leu209.B, Phe210.B, Val217.B, Leu261.B, Val262.B, Trp265.B, Phe268.B |
| TREK1 | |||
| K2P, TREK1, up state, human, 4twk | |||
| 4twk_EC | C | -13.6 | Phe51.A, Leu52.A, Val55.A, Ile59.A, Leu129.B, Gly130.B, Phe133.B, Lys271.B |
| D | -12.7 | Leu129.A, Gly130.A, Phe133.A, Lys271.A, Trp275.A, Leu52.B, Val55.B, Ile59.B | |
| E | -12.5 | Leu221.B, Leu225.B, Ile229.B, Ile233.B, Val273.B, Val274.B, Phe276.B, Trp277.B | |
| F | -12.3 | Tyr57.A, Ile60.A, Val64.A, Leu68.A, Gly154.B, Ile157.B, Phe158.B, Ile161.B, Leu165.B | |
| G | -12.3 | Ile215.A, Leu239.A, Ile242.A, Val288.A, Ile292.A, Ile157.B, Ile160.B, Ile161.B, Leu164.B | |
| H | -11.9 | Gly154.A, Ile157.A, Phe158.A, Ile161.A, Leu165.A, Val64.B, Leu68.B, Trp295.B | |
| I | -13.1 | Glu153.A, Ile157.A, Ile160.A, Ile161.A, Leu164.A, Leu239.B, Ile242.B, Ile292.B | |
| J | -11.9 | Leu216.B, Ala224.B, Ala227.B, Ile228.B, Lys231.B, Trp236.B, Ser237.B, Ala238.B | |
| K | -13.1 | Ile212.B, Ile215.B, Leu216.B, Cys219.B, Val223.B, Ser237.B, Ala238.B, Ile242.B | |
| 4twk_IC | C | -14.4 | Ile184.A, Phe185.A, Gly188.A, Ile189.A, Val192.A, Ile213.A, Phe217.A, Val220.A, Leu221.A, Leu225.A |
| D | -13.8 | Thr49.A, Ile50.A, Val53.A, Tyr57.A, Ile60.A, Leu296.A, Ile299.A, Ser300.A, Asn303.A, Leu304.A, Phe158.B | |
| E | -13.7 | Thr211.A, Phe214.A, Ile215.A, Ile242.A, Val246.A, Phe285.A, Val288.A, Met291.A, Ile292.A, Trp295.A, Ile160.B, Leu164.B | |
| K2P, TREK1, apo up state, mouse, 6cq6 | |||
| 6cq6_EC | C | -13.5 | Gly130.A, Ser131.A, Phe133.A, Phe134.A, Lys271.A, Pro272.A, Trp275.A, Phe51.B, Leu52.B, Val55.B |
| D | -13.2 | Phe51.A, Leu52.A, Val55.A, Ile59.A, Leu129.B, Gly130.B, Phe133.B, Asp268.B, Lys271.B, Pro272.B, Trp275.B | |
| E | -12.7 | Ile215.B, Leu216.B, Cys219.B, Ala224.B, Val228.B, Lys231.B, Ala238.B, Ile242.B | |
| F | -12.1 | Tyr57.A, Val64.A, Leu68.A, Gly154.B, Ile157.B, Phe158.B, Ile161.B, Leu165.B | |
| G | -11.9 | Ile215.A, Leu216.A, Ala224.A, Ala227.A, Val228.A, Lys231.A, Ala238.A, Ile242.A | |
| H | -11.8 | Ala238.A, Leu239.A, Ile242.A, Ile292.A, Ile157.B, Ile160.B, Ile161.B, Leu164.B, Leu165.B | |
| I | -12.4 | Ile157.A, Ile160.A, Ile161.A, Leu164.A, Ala238.B, Leu239.B, Ile242.B, Ile292.B | |
| 6cq6_IC | 1 | -14.1 | Ile184.B, Phe185.B, Gly186.B, Lys187.B, Gly188.B, Ile189.B, Phe217.B, Leu221.B, Leu225.B |
| K2P, TREK1, up state, ML335 complex,mouse, 6cq8 | |||
| 6cq8_EC | C | -13.4 | Ile215.B, Leu216.B, Cys219.B, Ala224.B, Ala227.B, Val228.B, Lys231.B, His232.B, Ala238.B, Ile242.B |
| D | -12.8 | Ile157.A, Ile160.A, Leu164.A, Ile215.B, Cys219.B, Ala238.B, Leu239.B, Ile242.B, Val288.B, Ile292.B | |
| 6cq8_IC | 1 | -14.4 | Thr49.A, Leu52.A, Val53.A, Val55.A, Leu56.A, Ile59.A, Lys304.A, Val307.A, Arg311.A |
| K2P, TREK1, up state, ML402 complex, mouse, 6cq9 | |||
| 6cq9_EC | C | -14.4 | Trp44.A, Val47.A, Ser48.A, Phe51.A, Val177.B, Asp268.B, Phe269.B, Pro272.B, Val273.B, Phe276.B |
| D | -14.4 | Ile212.A, Ile215.A, Leu216.A, Cys219.A, Val223.A, Ala224.A, Ala227.A, Val228.A, Lys231.A, Ala238.A, Ile242.A | |
| E | -13.9 | Ile212.B, Ile215.B, Leu216.B, Cys219.B, Val223.B, Ala224.B, Ala227.B, Val228.B, Lys231.B, Ala238.B, Ile242.B | |
| F | -12.8 | Ile157.A, Ile160.A, Ile161.A, Leu164.A, Leu165.A, Ala238.B, Leu239.B, Ile242.B, Ile292.B, Trp295.B | |
| G | -12.7 | Leu129.A, Gly130.A, Phe133.A, Pro272.A, Trp275.A, Phe276.A, Leu279.A, Phe51.B | |
| H | -12.5 | Ile215.A, Leu239.A, Ile242.A, Val288.A, Ile292.A, Trp295.A, Ile157.B, Ile160.B, Leu164.B | |
| 6cqp_IC | C | -14.2 | Thr49.A, Leu52.A, Val53.A, Val55.A, Leu56.A, Ile59.A, Lys304.A, Val307.A, Gly308.A, Arg311.A |
| D | -13.8 | Phe158.A, Ile161.A, Tyr162.A, Leu165.A, Leu169.A, Val53.B, Tyr57.B, Leu296.B, Ala300.B, Thr303.B, Lys304.B | |
| E | -13.6 | Phe185.B, Gly188.B, Ile189.B, Lys191.B, Val192.B, Ile213.B, Phe217.B, Leu221.B | |
| F | -13.6 | Ile184.A, Phe185.A, Lys187.A, Gly188.A, Lys191.A, Phe217.A, Leu221.A, Leu225.A | |
| G | -13.5 | Ile184.B, Lys187.B, Lys191.B, Leu221.B, Phe222.B, Val273.B, Phe276.B, Trp277.B | |
| TREK2 | |||
| K2P, TREK2, up state, human, 4bw5 | |||
| 4bw5_EC | A | -13.7 | Phe81.C, Val85.C, Leu159.D, Gly160.D, Phe163.D, Glu299.D, Trp300.D, Pro303.D, Phe307.D |
| B | -13.6 | Ile245.D, Leu246.D, Cys249.D, Val253.D, Thr254.D, Ala257.D, Val258.D, Lys261.D, Ala268.D, Ile272.D | |
| E | -12.6 | Ile187.C, Ile190.C, Leu191.C, Ile194.C, Phe195.C, Ile245.D, Leu269.D, Ile272.D, Val319.D, Ile323.D | |
| F | -12.3 | Phe188.C, Leu191.C, Phe195.C, Tyr87.D, Val94.D, Leu98.D, Trp326.D, Leu327.D | |
| G | -12.3 | Leu159.C, Gly160.C, Glu299.C, Pro303.C, Phe81.D, Val82.D, Val85.D, Val89.D | |
| 4bw5_IC | 1 | -14.1 | Phe195.C, Val238.D, Thr241.D, Ile242.D, Ile245.D, Met322.D, Ile323.D, Trp326.D, Val329.D |
| K2P, TREK2, down state, human, 4xdj | |||
| 4xdj_EC | C | -13.7 | Val251.A, Phe252.A, Ile259.A, Ile263.A, Arg298.A, Trp300.A, Leu304.A, Val311.A |
| D | -13.4 | Asp158.A, Leu159.A, Gly160.A, Phe163.A, Pro303.A, Val78.B, Phe81.B, Val85.B | |
| E | -13.2 | Val251.B, Phe252.B, Ile259.B, Ile263.B, Arg298.B, Trp300.B, Leu304.B, Val311.B | |
| 4xdj_IC | 1 | -14.1 | Ser218.A, Arg221.A, Leu243.A, Phe244.A, Ala247.A, Ile250.A, Val251.A, Ile255.A |
| K2P, TREK2, down state, norfluoxetine bound, human, 4xdk | |||
| 4xdk_EC | [none] | ||
| 4xdk_IC | E | -15.6 | Leu211.B, Ile214.B, Phe215.B, Lys217.B, Ser218.B, Arg221.B, Phe244.B, Val251.B, Phe252.B, Phe307.B, Trp308.B, Val311.B, Tyr315.B |
| F | -14.0 | Thr234.A, Arg237.A, Val238.A, Thr241.A, Ile242.A, Ile245.A, Ile323.A, Trp326.A, Leu327.A, Leu330.A, Ile194.B, Phe195.B | |
| K2P, TREK2, down state, Br-fluoxetine bound, human, 4xdl | |||
| 4xdl_EC | A | -14.3 | Phe81.C, Val85.C, Leu159.D, Gly160.D, Phe163.D, Glu299.D, Trp300.D, Pro303.D, Phe307.D |
| B | -12.5 | Leu159.C, Gly160.C, Glu299.C, Trp300.C, Pro303.C, Phe81.D, Val82.D, Val85.D, Val89.D | |
| E | -12.1 | Ile187.C, Ile190.C, Leu191.C, Ile194.C, Phe195.C, Ala268.D, Leu269.D, Ile272.D | |
| F | -12.0 | Ile245.C, Ala268.C, Leu269.C, Ile272.C, Ile187.D, Ile190.D, Leu191.D, Ile194.D | |
| 4xdl_IC | E | -14.1 | Ser218.D, Ile219.D, Val222.D, Ser240.D, Leu243.D, Phe244.D, Ala247.D, Ile250.D, Ile255.D |
| F | -14.1 | Leu211.D, Ile214.D, Ser218.D, Arg221.D, Phe252.D, Trp308.D, Val311.D, Tyr315.D | |
| G | -13.1 | Ile194.C, Pro198.C, Thr234.D, Val238.D, Ile245.D, Thr280.D, Leu320.D, Ile323.D, Leu327.D | |
| I | -13.1 | Ile214.C, Phe215.C, Ser218.C, Phe244.C, Val251.C, Phe252.C, Val311.C, Tyr315.C | |
| TWIK | |||
| K2P, TWIK, human, 3ukm | |||
| 3ukm_EC | C | -13.3 | Cys194.B, Phe195.B, Val202.B, Leu206.B, Phe241.B, Leu244.B, Tyr245.B, Gly248.B |
| D | -13.2 | Cys194.A, Phe195.A, Val202.A, Leu206.A, Phe241.A, Leu244.A, Tyr245.A, Gly248.A, Ile249.A | |
| F | -12.1 | Tyr33.B, Phe36.B, Val40.B, Val44.B, Gly129.B, Phe133.B, Ile136.B, Ile140.B | |
| G | -12.1 | Tyr33.A, Phe36.A, Val40.A, Val44.A, Gly129.A, Phe133.A, Ile136.A, Ile140.A | |
| 3ukm_IC | [none] | ||