Interfacial Cholesterol Binding Sites on GABAA Receptors

[EC and IC, extracellular and intracelluar interfaces, respectively; Chl gives the letter assigned to cholesterol molecules in the PDB files; Units of E, kcals/mol with molar concentration units]

PDB Chl E Local Residues
Homo-pentameric GABAA chimeras
β3 chimera, desensitized state, human, 4cof 
4cof_EC F -14.8 Ala280.C, Met283.C, Thr434.C, Phe438.C, Val441.C, Tyr442.C, Tyr445.C, Tyr446.C
G -14.5 Met283.E, Thr434.E, Leu437.E, Phe438.E, Val441.E, Tyr442.E, Tyr445.E, Tyr446.E
H -14.1 Met283.D, Thr434.D, Leu437.D, Phe438.D, Val441.D, Tyr442.D, Tyr445.D, Tyr446.D
I -13.5 Ile218.D, Ile222.D, Tyr226.D, Ile230.D, Ile234.D, Trp237.D, Pro432.D, Ser436.D, Asn439.D, Trp443.D
J -13.3 Ile218.C, Ile222.C, Tyr226.C, Ile230.C, Ile234.C, Trp237.C, Pro432.C, Phe435.C, Asn439.C, Trp443.C
K -13.3 Ile218.B, Ile222.B, Tyr226.B, Ile230.B, Ile234.B, Trp237.B, Pro432.B, Ser436.B, Asn439.B, Trp443.B
L -13.1 Met283.B, Thr434.B, Leu437.B, Phe438.B, Val441.B, Tyr442.B, Tyr445.B, Tyr446.B
M -12.7 Ile218.A, Ile222.A, Met227.A, Ile230.A, Ile234.A, Trp237.A, Pro432.A, Asn439.A
O -13.3 Ile218.E, Ile222.E, Tyr226.E, Ile230.E, Ile234.E, Trp237.E, Pro432.E, Ser436.E, Asn439.E, Trp443.E
P -13.1 Met283.A, Thr434.A, Leu437.A, Phe438.A, Val441.A, Tyr442.A, Tyr445.A, Tyr446.A
4cof_IC F -13.5 Gly287.B, Val290.B, Phe291.B, Leu294.B, Trp426.B, Ser427.B, Val430.B, Phe431.B, Thr434.B
G -13.3 Gly287.C, Val290.C, Phe291.C, Leu294.C, Trp426.C, Ser427.C, Val430.C, Phe431.C, Thr434.C, Phe438.C
H -13.3 Ile230.B, Ile234.B, Trp237.B, Trp241.B, Pro432.B, Phe435.B, Ser436.B, Phe301.C
I -12.9 Ile230.A, Ile234.A, Trp237.A, Trp241.A, Pro432.A, Phe435.A, Ser436.A, Phe301.B
J -12.7 Ile230.C, Ile234.C, Trp237.C, Trp241.C, Pro432.C, Phe435.C, Ser436.C, Phe301.D
K -13.7 Phe301.A, Ile230.E, Ile234.E, Trp237.E, Trp241.E, Pro432.E, Phe435.E, Ser436.E
L -13.5 Gly287.A, Val290.A, Phe291.A, Leu294.A, Trp426.A, Ser427.A, Val430.A, Phe431.A, Thr434.A, Phe438.A
M -13.4 Gly287.E, Val290.E, Phe291.E, Leu294.E, Ile423.E, Trp426.E, Ser427.E, Val430.E, Phe431.E, Thr434.E, Phe438.E
N -13.0 Gly287.D, Val290.D, Phe291.D, Leu294.D, Ile423.D, Trp426.D, Ser427.D, Val430.D, Phe431.D, Thr434.D, Phe438.D
O -13.0 Ile230.D, Ile234.D, Trp237.D, Trp241.D, Pro432.D, Phe435.D, Ser436.D, Phe301.E
α5 chimera plus pregnanolone, desensitized state, human, 5o8f 
5o8f_EC F -14.1 Trp291.D, Val295.D, Leu405.D, Phe409.D, Val412.D, Tyr413.D, Thr416.D, Tyr417.D
G -13.9 Trp291.E, Val295.E, Phe299.E, Leu405.E, Phe409.E, Val412.E, Thr416.E, Tyr417.E
H -13.6 Val230.D, Ile238.D, Pro403.D, Ile404.D, Gly407.D, Asn410.D, Leu411.D, Trp414.D
I -14.4 Ala288.A, Trp291.A, Val295.A, Leu405.A, Phe409.A, Val412.A, Tyr413.A, Thr416.A, Tyr417.A
J -14.4 Trp291.C, Val295.C, Phe299.C, Leu405.C, Phe409.C, Val412.C, Thr416.C, Tyr417.C
P -13.3 Val230.A, Ile238.A, Pro403.A, Ile404.A, Gly407.A, Asn410.A, Leu411.A, Trp414.A
Q -13.2 Val230.E, Leu235.E, Ile238.E, Pro403.E, Ile404.E, Gly407.E, Asn410.E, Trp414.E
R -12.7 Ala286.D, Trp291.D, Ala294.D, Tyr297.D, Ala298.D, Phe301.D, Ser302.D, Ile305.D, Val230.E, Ile231.E, Leu235.E, Met239.E
T -13.0 Ala286.B, Trp291.B, Ala294.B, Tyr297.B, Ala298.B, Ser302.B, Ile305.B, Val230.C, Ile231.C, Leu235.C
U -12.6 Ala286.A, Trp291.A, Ala294.A, Tyr297.A, Ala298.A, Phe301.A, Ser302.A, Ile305.A, Val230.B, Ile231.B, Leu235.B
W -14.0 Trp291.B, Val295.B, Phe299.B, Leu405.B, Phe409.B, Val412.B, Thr416.B, Tyr417.B
X -13.3 Ile226.B, Val230.B, Ile238.B, Pro403.B, Ile404.B, Gly407.B, Asn410.B, Leu411.B, Trp414.B
Y -13.3 Val230.C, Leu235.C, Ile238.C, Pro403.C, Ile404.C, Gly407.C, Asn410.C, Leu411.C, Trp414.C
5o8f_IC F -15.0 Val295.E, Ala298.E, Phe299.E, Ser302.E, Glu306.E, Phe313.E, Arg320.E, Ile394.E, Val401.E, Phe402.E, Leu405.E
G -14.4 Ala298.D, Ser302.D, Ile305.D, Glu306.D, Thr309.D, Phe313.D, Arg320.D, Ile394.D, Met239.E
I -13.1 Thr309.D, Tyr312.D, Phe313.D, Ile238.E, Ile242.E, Trp249.E, Pro403.E, Phe406.E
J -13.1 Ile242.A, Trp249.A, Pro403.A, Phe406.A, Gly407.A, Ile305.E, Thr309.E, Tyr312.E, Phe313.E
P -13.0 Ile305.C, Thr309.C, Tyr312.C, Phe313.C, Ile242.D, Trp249.D, Pro403.D, Phe406.D, Gly407.D
T -12.9 Val295.D, Ala298.D, Phe299.D, Lys393.D, Ile394.D, Met397.D, Val401.D, Leu405.D
V -15.2 Val295.A, Ala298.A, Phe299.A, Ser302.A, Glu306.A, Arg320.A, Ile394.A, Val401.A, Phe402.A, Leu405.A
W -14.2 Val295.B, Ala298.B, Phe299.B, Ser302.B, Arg320.B, Ile394.B, Val401.B, Phe402.B, Leu405.B, Phe409.B
X -12.7 Ile305.B, Thr309.B, Tyr312.B, Phe313.B, Ile242.C, Trp249.C, Pro403.C, Phe406.C, Gly407.C
Z -14.3 Ile305.A, Thr309.A, Tyr312.A, Phe313.A, Ile242.B, Trp249.B, Pro403.B, Phe406.B, Gly407.B
α5 chimera, apo state, human, 5ojm 
5ojm_EC F -14.6 Trp291.B, Val295.B, Leu405.B, Phe409.B, Val412.B, Tyr413.B, Thr416.B, Tyr417.B
G -14.2 Trp291.A, Val295.A, Phe299.A, Leu405.A, Phe409.A, Val412.A, Thr416.A, Tyr417.A
H -13.8 Val230.E, Leu235.E, Ile238.E, Ile242.E, Pro403.E, Ile404.E, Gly407.E, Asn410.E, Leu411.E, Trp414.E
I -14.2 Trp291.C, Val295.C, Leu405.C, Phe409.C, Val412.C, Tyr413.C, Thr416.C, Tyr417.C
J -13.4 Val230.B, Ile238.B, Pro403.B, Ile404.B, Gly407.B, Asn410.B, Leu411.B, Trp414.B
P -13.3 Ile238.A, Ile242.A, Pro403.A, Gly407.A, Asn410.A, Leu411.A, Trp414.A, Leu418.A
Q -13.3 Ala286.A, Trp291.A, Ala294.A, Tyr297.A, Ala298.A, Phe301.A, Ser302.A, Ile305.A, Ile231.B, Leu235.B
R -13.9 Ala288.D, Trp291.D, Val295.D, Leu405.D, Phe409.D, Val412.D, Tyr413.D, Thr416.D, Tyr417.D
S -12.9 Ile231.A, Leu235.A, Ala286.E, Trp291.E, Ala294.E, Tyr297.E, Ala298.E, Phe301.E, Ser302.E, Ile305.E
T -13.3 Val295.E, Phe299.E, Leu405.E, Phe409.E, Val412.E, Tyr413.E, Thr416.E, Tyr417.E
U -13.0 Trp291.C, Ala294.C, Tyr297.C, Ala298.C, Phe301.C, Ser302.C, Ile305.C, Ile231.D, Leu235.D
V -12.9 Trp291.B, Ala294.B, Tyr297.B, Ala298.B, Phe301.B, Ser302.B, Ile305.B, Val230.C, Ile231.C, Leu235.C
W -13.5 Val230.D, Leu235.D, Ile238.D, Pro403.D, Ile404.D, Gly407.D, Asn410.D, Leu411.D, Trp414.D
X -13.2 Ala286.D, Trp291.D, Ala294.D, Tyr297.D, Ala298.D, Phe301.D, Ser302.D, Ile305.D, Ile231.E, Leu235.E
Y -13.2 Val230.C, Leu235.C, Ile238.C, Pro403.C, Ile404.C, Gly407.C, Asn410.C, Leu411.C, Trp414.C
5ojm_IC F -13.3 Ala298.B, Ser302.B, Glu306.B, Lys393.B, Ile394.B, Met397.B, Ser398.B, Val401.B, Phe402.B, Leu405.B
G -13.3 Ala298.E, Ser302.E, Ile305.E, Glu306.E, Ile394.E, Met397.E, Ser398.E, Val401.E, Phe402.E
H -13.3 Val295.A, Ala298.A, Phe299.A, Ser302.A, Glu306.A, Lys393.A, Ile394.A, Met397.A, Val401.A, Phe402.A, Leu405.A
J -13.3 Tyr297.A, Ala298.A, Ser302.A, Ile305.A, Glu306.A, Thr309.A, Phe313.A, Ile394.A, Met239.B
P -13.2 Ile238.A, Ile242.A, Trp249.A, Pro403.A, Phe406.A, Gly407.A, Ile305.E, Thr309.E, Tyr312.E
Q -14.5 Phe301.A, Ile305.A, Ala308.A, Thr309.A, Tyr312.A, Phe313.A, Ile238.B, Met239.B, Ile242.B, Val246.B, Trp249.B
T -13.8 Tyr297.B, Ala298.B, Phe301.B, Ser302.B, Ile305.B, Thr309.B, Phe313.B, Met239.C
U -13.7 Ile305.C, Ala308.C, Thr309.C, Tyr312.C, Ile238.D, Ile242.D, Trp249.D, Pro403.D, Phe406.D, Gly407.D
V -13.3 Ala298.B, Ser302.B, Glu306.B, Lys393.B, Ile394.B, Met397.B, Ser398.B, Val401.B, Phe402.B, Leu405.B
W -13.2 Ala298.D, Ser302.D, Ile305.D, Glu306.D, Ile394.D, Met397.D, Ser398.D, Val401.D, Phe402.D
Y -13.0 Val295.C, Phe299.C, Ser302.C, Glu306.C, Thr309.C, Ile394.C, Ser398.C, Val401.C, Phe402.C, Leu405.C
Z -13.2 Phe301.B, Ile305.B, Ala308.B, Thr309.B, Tyr312.B, Ile238.C, Met239.C, Ile242.C, Val246.C, Trp249.C
α1 chimera, desensitized state, human, 5osa
5osa_EC F -14.7 Trp287.B, Val291.B, Phe295.B, Leu402.B, Phe406.B, Val409.B, Tyr410.B, Thr413.B, Tyr414.B
G -14.3 Trp287.E, Val291.E, Leu402.E, Phe406.E, Val409.E, Tyr410.E, Thr413.E, Tyr414.E
H -14.2 Ala284.C, Trp287.C, Leu402.C, Ile405.C, Phe406.C, Val409.C, Tyr410.C, Tyr414.C
I -14.2 Ala284.D, Trp287.D, Leu402.D, Ile405.D, Phe406.D, Val409.D, Tyr410.D, Tyr414.D
J -13.9 Trp287.A, Val291.A, Leu402.A, Phe406.A, Val409.A, Tyr410.A, Thr413.A, Tyr414.A
K -13.5 Val226.E, Leu231.E, Ile234.E, Pro400.E, Leu401.E, Gly404.E, Asn407.E, Leu408.E, Trp411.E
L -13.5 Val226.D, Leu231.D, Ile234.D, Pro400.D, Leu401.D, Gly404.D, Asn407.D, Trp411.D
M -13.3 Ile227.D, Leu231.D, Ala282.E, Asp286.E, Trp287.E, Ala290.E, Tyr293.E, Ala294.E, Phe297.E, Ser298.E, Ile301.E
N -13.2 Ile234.C, Pro400.C, Leu401.C, Gly404.C, Asn407.C, Leu408.C, Trp411.C, Leu415.C
O -13.1 Ile227.C, Leu231.C, Met235.C, Arg273.D, Ala282.D, Asp286.D, Trp287.D, Ala290.D, Tyr293.D, Ala294.D, Phe297.D, Ser298.D, Ile301.D
P -13.6 Tyr193.A, Val226.A, Leu231.A, Ile234.A, Ile238.A, Pro400.A, Leu401.A, Gly404.A, Asn407.A, Trp411.A
Q -13.1 Ile227.B, Leu231.B, Met235.B, Ala282.C, Asp286.C, Trp287.C, Ala290.C, Tyr293.C, Phe297.C, Ile301.C
R -13.4 Val226.B, Leu231.B, Ile234.B, Pro400.B, Leu401.B, Gly404.B, Asn407.B, Trp411.B
S -13.4 Ala282.A, Asp286.A, Trp287.A, Ala290.A, Tyr293.A, Ala294.A, Phe297.A, Ser298.A, Ile301.A, Ile227.E, Leu231.E
T -13.4 Ile227.A, Leu231.A, Ala282.B, Trp287.B, Ala290.B, Tyr293.B, Ala294.B, Phe297.B, Ser298.B, Ile301.B
5osa_IC F -13.7 Ile238.D, Val242.D, Trp245.D, Phe403.D, Ala304.E, Thr305.E, Tyr308.E, Phe309.E
G -13.7 Val291.C, Ala294.C, Phe295.C, Ser298.C, Glu302.C, Ile391.C, Leu394.C, Ser395.C, Ala398.C, Phe399.C, Leu402.C
H -13.6 Val291.D, Ala294.D, Ser298.D, Glu302.D, Lys390.D, Ile391.D, Leu394.D, Ser395.D, Ala398.D, Phe399.D
I -13.6 Val291.E, Ala294.E, Ser298.E, Glu302.E, Ile391.E, Leu394.E, Ser395.E, Ala398.E, Phe399.E
J -13.0 Ala294.E, Phe297.E, Ser298.E, Ile301.E, Glu302.E, Thr305.E, Ile391.E, Phe399.E
K -12.8 Ala304.A, Thr305.A, Tyr308.A, Phe309.A, Ile234.E, Ile238.E, Val242.E, Trp245.E, Phe403.E
L -12.7 Ile234.C, Ile238.C, Trp245.C, Pro400.C, Phe403.C, Ile301.D, Thr305.D, Tyr308.D, Phe309.D
M -13.6 Met235.C, Ala294.D, Phe297.D, Ser298.D, Ile301.D, Thr305.D, Arg316.D, Ile391.D
N -12.5 Met235.B, Ile238.B, Val242.B, Trp245.B, Phe297.C, Ile301.C, Thr305.C, Tyr308.C, Phe309.C
O -13.5 Met235.B, Ala294.C, Phe297.C, Ser298.C, Ile301.C, Thr305.C, Phe309.C, Arg316.C, Ile391.C
Q -13.7 Val291.B, Ala294.B, Phe295.B, Ser298.B, Ile391.B, Leu394.B, Ser395.B, Ala398.B, Phe399.B, Leu402.B
R -13.6 Val291.A, Ala294.A, Phe295.A, Ser298.A, Glu302.A, Ile391.A, Leu394.A, Ser395.A, Ala398.A, Phe399.A, Leu402.A
S -13.6 Ile234.A, Ile238.A, Val242.A, Trp245.A, Phe403.A, Ala304.B, Thr305.B, Tyr308.B, Phe309.B
T -13.0 Ala294.B, Ser298.B, Ile301.B, Glu302.B, Thr305.B, Phe309.B, Arg316.B, Ile391.B
U -12.6 Ala294.A, Phe297.A, Ser298.A, Ile301.A, Thr305.A, Phe309.A, Arg316.A, Ile391.A, Met235.E
α1 chimera, plus tetrahydrodeoxycorticosterone, desensitized state, human, 5osb
5osb_EC F -14.4 Trp287.C, Val291.C, Phe295.C, Leu402.C, Phe406.C, Val409.C, Tyr410.C, Tyr414.C
G -13.4 Val226.E, Ile234.E, Pro400.E, Leu401.E, Gly404.E, Asn407.E, Leu408.E, Trp411.E
H -13.4 Val226.A, Ile234.A, Pro400.A, Leu401.A, Gly404.A, Asn407.A, Leu408.A, Trp411.A, Leu415.A
I -13.3 Trp287.B, Val291.B, Phe295.B, Ala398.B, Leu402.B, Phe406.B, Val409.B, Tyr410.B, Tyr414.B
J -13.2 Val226.B, Ile234.B, Pro400.B, Leu401.B, Gly404.B, Asn407.B, Leu408.B, Trp411.B, Leu415.B
K -13.2 Trp287.A, Val291.A, Phe295.A, Ala398.A, Leu402.A, Phe406.A, Val409.A, Tyr410.A, Tyr414.A
L -14.3 Ala284.D, Trp287.D, Leu402.D, Ile405.D, Phe406.D, Val409.D, Tyr410.D, Tyr414.D
M -13.1 Ile227.C, Leu231.C, Met235.C, Ala282.D, Asp286.D, Trp287.D, Ala290.D, Ala294.D, Phe297.D, Ile301.D
N -13.4 Asp286.A, Trp287.A, Ala290.A, Tyr293.A, Ala294.A, Phe297.A, Ser298.A, Ile301.A, Ile227.E, Leu231.E
O -13.2 Ile227.A, Leu231.A, Met235.A, Trp287.B, Ala290.B, Tyr293.B, Ala294.B, Phe297.B, Ser298.B, Ile301.B
P -13.1 Ile227.B, Leu231.B, Met235.B, Asp286.C, Trp287.C, Ala290.C, Tyr293.C, Ala294.C, Phe297.C, Ser298.C, Ile301.C
Q -13.3 Trp287.E, Val291.E, Phe295.E, Ala398.E, Leu402.E, Phe406.E, Val409.E, Tyr410.E, Tyr414.E
R -13.2 Tyr193.D, Val226.D, Ile234.D, Pro400.D, Leu401.D, Gly404.D, Asn407.D, Leu408.D, Trp411.D, Leu415.D
S -13.2 Tyr193.C, Val226.C, Ile234.C, Leu401.C, Gly404.C, Asn407.C, Leu408.C, Trp411.C, Leu415.C
T -12.9 Ile227.D, Leu231.D, Met235.D, Ala282.E, Trp287.E, Ala290.E, Tyr293.E, Ala294.E, Phe297.E, Ser298.E, Ile301.E
5osb_IC F -13.9 Val291.B, Ala294.B, Phe295.B, Ser298.B, Glu302.B, Ile391.B, Leu394.B, Ser395.B, Ala398.B, Phe399.B
G -13.8 Val291.C, Ala294.C, Phe295.C, Ser298.C, Glu302.C, Lys390.C, Ile391.C, Leu394.C, Ser395.C, Ala398.C, Phe399.C, Leu402.C
H -13.4 Val291.A, Ala294.A, Phe295.A, Ser298.A, Glu302.A, Ile391.A, Leu394.A, Ser395.A, Ala398.A, Phe399.A
I -13.4 Ile234.B, Ile238.B, Trp245.B, Pro400.B, Phe403.B, Ile301.C, Thr305.C, Tyr308.C, Phe309.C
J -13.3 Ile238.A, Val242.A, Trp245.A, Phe403.A, Ala304.B, Thr305.B, Tyr308.B, Phe309.B
K -12.9 Ala294.A, Phe297.A, Ser298.A, Ile301.A, Glu302.A, Thr305.A, Arg316.A, Ile391.A
L -13.7 Met235.B, Ala294.C, Phe297.C, Ser298.C, Ile301.C, Thr305.C, Phe309.C, Arg316.C, Ile391.C
M -13.3 Met235.A, Ala294.B, Phe297.B, Ser298.B, Ile301.B, Thr305.B, Phe309.B, Arg316.B
O -14.0 Val291.E, Ala294.E, Phe295.E, Ser298.E, Glu302.E, Ile391.E, Leu394.E, Ser395.E, Ala398.E, Phe399.E
P -13.8 Val291.D, Ala294.D, Phe295.D, Ser298.D, Glu302.D, Lys390.D, Ile391.D, Leu394.D, Ser395.D, Ala398.D, Phe399.D, Leu402.D
Q -13.0 Ile234.D, Ile238.D, Trp245.D, Pro400.D, Phe403.D, Ile301.E, Thr305.E, Tyr308.E, Phe309.E
R -12.9 Ile234.C, Ile238.C, Trp245.C, Pro400.C, Phe403.C, Gly404.C, Asn407.C, Tyr308.D
S -13.8 Met235.D, Ala294.E, Phe297.E, Ser298.E, Ile301.E, Thr305.E, Phe309.E, Arg316.E, Ile391.E
U -12.4 Tyr308.A, Phe309.A, Ile234.E, Ile238.E, Trp245.E, Pro400.E, Phe403.E, Gly404.E
α1 chimera, plus pregnenolone sulfate, desensitized state, human, 5osc
5osc_EC F -14.7 Ile227.D, Leu231.D, Met235.D, Ser269.E, Arg273.E, Asp286.E, Ile289.E, Ala290.E, Tyr293.E, Ala294.E
G -14.2 Ala284.E, Trp287.E, Leu402.E, Ile405.E, Phe406.E, Val409.E, Tyr410.E, Tyr414.E
H -13.7 Ile238.E, Pro400.E, Phe403.E, Gly404.E, Asn407.E, Leu408.E, Trp411.E, Ala412.E, Leu415.E
I -13.7 Ala284.D, Trp287.D, Leu402.D, Ile405.D, Phe406.D, Val409.D, Tyr410.D, Tyr414.D
J -13.5 Trp287.C, Val291.C, Ala294.C, Phe295.C, Ser298.C, Ala398.C, Leu402.C, Phe406.C, Val409.C, Tyr414.C
K -13.4 Ile227.C, Leu231.C, Ser269.D, Arg273.D, Asp286.D, Ala290.D, Tyr293.D, Ala294.D, Phe297.D, Ser298.D, Ile301.D
L -13.3 Tyr193.D, Val226.D, Ile234.D, Ile238.D, Pro400.D, Leu401.D, Gly404.D, Asn407.D, Trp411.D
N -13.2 Ile234.C, Ile238.C, Pro400.C, Gly404.C, Asn407.C, Leu408.C, Trp411.C, Ala412.C, Leu415.C
O -14.9 Ala284.A, Trp287.A, Leu402.A, Ile405.A, Phe406.A, Val409.A, Tyr410.A, Tyr414.A
P -13.5 Trp287.B, Val291.B, Phe295.B, Ala398.B, Leu402.B, Phe406.B, Val409.B, Tyr410.B, Tyr414.B
Q -13.2 Tyr193.A, Val226.A, Ile234.A, Pro400.A, Leu401.A, Gly404.A, Asn407.A, Trp411.A, Leu415.A
R -13.3 Ile227.A, Leu231.A, Met235.A, Ala282.B, Asp286.B, Trp287.B, Ala290.B, Tyr293.B, Ala294.B, Phe297.B, Ser298.B, Ile301.B
U -13.1 Ala282.A, Trp287.A, Ala290.A, Tyr293.A, Ala294.A, Phe297.A, Ser298.A, Ile301.A, Ile227.E, Leu231.E
W -13.7 Ile227.B, Leu231.B, Ala290.C, Tyr293.C, Ala294.C, Phe297.C, Ser298.C, Ile301.C
5osc_IC F -14.1 Val291.E, Phe295.E, Ser298.E, Ile391.E, Leu394.E, Ser395.E, Ala398.E, Phe399.E, Leu402.E, Phe406.E
G -13.7 Ile238.C, Val242.C, Trp245.C, Pro400.C, Phe403.C, Ala304.D, Thr305.D, Tyr308.D, Phe309.D
H -13.6 Val291.D, Phe295.D, Ser298.D, Ile391.D, Leu394.D, Ser395.D, Ala398.D, Phe399.D, Leu402.D, Phe406.D
I -13.1 Ile234.D, Ile238.D, Val242.D, Trp245.D, Pro400.D, Phe403.D, Ile301.E, Thr305.E, Tyr308.E, Phe309.E
J -12.9 Val291.C, Ala294.C, Phe295.C, Ser298.C, Lys390.C, Ile391.C, Leu394.C, Ser395.C, Ala398.C, Phe399.C
K -13.2 Ala294.D, Phe297.D, Ser298.D, Ile301.D, Thr305.D, Phe309.D, Arg316.D, Ile391.D
L -13.2 Ile301.A, Thr305.A, Tyr308.A, Phe309.A, Ile234.E, Ile238.E, Trp245.E, Pro400.E, Phe403.E, Gly404.E
N -14.1 Val291.A, Phe295.A, Ser298.A, Lys390.A, Ile391.A, Leu394.A, Ser395.A, Ala398.A, Phe399.A, Leu402.A, Phe406.A
O -13.7 Val291.B, Ala294.B, Phe295.B, Ser298.B, Lys390.B, Ile391.B, Leu394.B, Ser395.B, Ala398.B, Phe399.B, Leu402.B
P -13.6 Ala294.C, Phe297.C, Ser298.C, Ile301.C, Glu302.C, Thr305.C, Lys390.C, Ile391.C, Leu394.C, Ser395.C, Phe399.C
Q -12.9 Ile238.B, Val242.B, Trp245.B, Pro400.B, Phe403.B, Ala304.C, Thr305.C, Tyr308.C, Phe309.C
R -12.8 Ala294.B, Phe297.B, Ser298.B, Ile301.B, Thr305.B, Phe309.B, Arg316.B, Ile391.B
S -14.3 Ile238.A, Val242.A, Trp245.A, Ile301.B, Ala304.B, Thr305.B, Tyr308.B, Phe309.B
T -13.4 Tyr293.A, Phe297.A, Ser298.A, Ile301.A, Thr305.A, Phe309.A, Arg316.A, Ile391.A, Met235.E
α1 chimera, plus alphaxalone, desensitized state, human, 6cdu
6cdu_EC F -13.0 Ile223.E, Val227.E, Ile235.E, Pro401.E, Phe404.E, Gly405.E, Asn408.E, Leu409.E, Trp412.E
H -13.1 Ala281.A, Ala283.A, Trp288.A, Ala291.A, Ala295.A, Phe298.A, Ser299.A, Ile302.A, Val227.E, Ile228.E, Leu232.E, Met236.E
I -12.9 Ile223.A, Val227.A, Leu232.A, Ile235.A, Ile239.A, Pro401.A, Gly405.A, Asn408.A, Leu409.A, Trp412.A
J -13.2 Ile223.B, Ile235.B, Ile239.B, Pro401.B, Phe404.B, Gly405.B, Asn408.B, Leu409.B, Trp412.B, Leu416.B
K -13.2 Ile228.D, Leu232.D, Met236.D, Ala281.E, Ala283.E, Asp287.E, Trp288.E, Ala291.E, Tyr294.E, Phe298.E, Ser299.E, Ile302.E
L -13.2 Ile223.C, Gly224.C, Val227.C, Leu232.C, Ile235.C, Gly405.C, Asn408.C, Leu409.C, Trp412.C
M -13.3 Ile223.D, Val227.D, Leu232.D, Ile235.D, Ile239.D, Pro401.D, Phe404.D, Gly405.D, Asn408.D, Trp412.D
N -12.8 Ile228.C, Leu232.C, Met236.C, Ala283.D, Trp288.D, Ala291.D, Ala295.D, Phe298.D, Ser299.D, Ile302.D
O -12.8 Ile228.B, Leu232.B, Ala283.C, Asp287.C, Trp288.C, Ala291.C, Tyr294.C, Phe298.C, Ser299.C, Ile302.C
P -12.5 Trp288.C, Val292.C, Ala295.C, Phe296.C, Leu403.C, Phe407.C, Val410.C, Thr414.C, Tyr415.C
Q -12.5 Trp288.D, Val292.D, Phe296.D, Leu403.D, Phe407.D, Val410.D, Thr414.D, Tyr415.D
R -12.6 Trp288.E, Val292.E, Phe296.E, Leu403.E, Phe407.E, Val410.E, Thr414.E, Tyr415.E
S -12.4 Trp288.A, Val292.A, Phe296.A, Leu403.A, Phe407.A, Val410.A, Thr414.A, Tyr415.A
T -12.4 Ile228.A, Leu232.A, Ala281.B, Ala283.B, Asp287.B, Trp288.B, Ala291.B, Tyr294.B, Phe298.B, Ile302.B
6cdu_IC F -14.4 Ile239.C, Val243.C, Trp246.C, Asn408.C, Ile302.D, Ala305.D, Thr306.D, Tyr309.D
G -13.8 Ile239.D, Val243.D, Trp246.D, Phe298.E, Ile302.E, Ala305.E, Thr306.E, Tyr309.E
I -12.8 Val292.D, Ala295.D, Phe296.D, Ser299.D, Glu303.D, Thr306.D, Ile392.D, Leu395.D, Phe400.D, Leu403.D
J -12.6 Met236.D, Tyr294.E, Ala295.E, Phe298.E, Ser299.E, Ile302.E, Thr306.E, Phe310.E, Ile392.E
L -13.0 Ile239.B, Val243.B, Trp246.B, Phe298.C, Ile302.C, Ala305.C, Thr306.C, Tyr309.C
M -12.6 Met236.B, Ala295.C, Phe298.C, Ser299.C, Ile302.C, Glu303.C, Thr306.C, Ile392.C
O -14.7 Ile235.A, Ile239.A, Val243.A, Trp246.A, Ile302.B, Ala305.B, Thr306.B, Tyr309.B
P -13.4 Val292.A, Phe296.A, Ser299.A, Glu303.A, Thr306.A, Val307.A, Ile392.A, Ser396.A, Phe400.A, Leu403.A
Q -12.9 Phe298.A, Ile302.A, Ala305.A, Thr306.A, Tyr309.A, Ile239.E, Val243.E, Trp246.E
T -13.0 Val292.E, Ala295.E, Phe296.E, Ser299.E, Ile392.E, Leu395.E, Ala399.E, Phe400.E, Leu403.E
α1 chimera, apo, resting state with closed pore, human, 6c1s
6d1s_EC F -14.7 Ser270.A, Arg274.A, Asp287.A, Ile290.A, Ala291.A, Tyr294.A, Ala295.A, Phe298.A, Ile302.A, Ile228.E, Leu232.E, Met236.E
G -14.5 Ile228.B, Leu232.B, Met236.B, Ser270.C, Arg274.C, Asp287.C, Ile290.C, Ala291.C, Tyr294.C, Ala295.C, Phe298.C, Ile302.C
H -13.6 Ile228.D, Leu232.D, Met236.D, Ser270.E, Arg274.E, Asp287.E, Ile290.E, Ala291.E, Tyr294.E, Ala295.E, Phe298.E, Ile302.E
I -13.8 Trp288.E, Val292.E, Leu403.E, Ile406.E, Phe407.E, Val410.E, Tyr411.E, Thr414.E, Tyr415.E
J -13.6 Ile228.A, Leu232.A, Met236.A, Ser270.B, Arg274.B, Asp287.B, Ile290.B, Ala291.B, Tyr294.B, Ala295.B, Phe298.B, Ile302.B
K -13.5 Ile223.B, Val227.B, Ile235.B, Pro401.B, Leu402.B, Gly405.B, Asn408.B, Leu409.B, Trp412.B
L -13.3 Ile223.C, Ile235.C, Pro401.C, Gly405.C, Asn408.C, Leu409.C, Trp412.C, Leu416.C
M -13.3 Trp288.C, Leu403.C, Ile406.C, Phe407.C, Val410.C, Tyr411.C, Thr414.C, Tyr415.C
N -13.2 Trp288.B, Leu403.B, Ile406.B, Phe407.B, Val410.B, Tyr411.B, Thr414.B, Tyr415.B
O -13.2 Trp288.D, Val292.D, Leu403.D, Ile406.D, Phe407.D, Val410.D, Tyr411.D, Thr414.D, Tyr415.D
P -13.1 Ile228.C, Leu232.C, Ala283.D, Trp288.D, Ala291.D, Tyr294.D, Ala295.D, Phe298.D, Ser299.D, Ile302.D
S -12.6 Ile239.A, Pro401.A, Phe404.A, Gly405.A, Asn408.A, Leu409.A, Trp412.A, Leu416.A
T -13.5 Trp288.A, Val292.A, Leu403.A, Phe407.A, Val410.A, Tyr411.A, Thr414.A, Tyr415.A
U -13.4 Val227.E, Leu232.E, Ile235.E, Pro401.E, Leu402.E, Gly405.E, Asn408.E, Leu409.E, Trp412.E
V -13.5 Gly224.D, Val227.D, Leu232.D, Ile235.D, Pro401.D, Leu402.D, Gly405.D, Asn408.D, Leu409.D, Trp412.D
6d1s_IC F -14.4 Val292.B, Ala295.B, Ser299.B, Lys391.B, Ile392.B, Asp393.B, Leu395.B, Ser396.B, Ala399.B, Phe400.B, Leu403.B
G -12.9 Val292.D, Ala295.D, Phe296.D, Ser299.D, Ile302.D, Glu303.D, Thr306.D, Val307.D, Ile392.D, Phe400.D, Leu403.D
H -12.9 Val292.C, Ala295.C, Phe296.C, Ser299.C, Glu303.C, Thr306.C, Ile392.C, Leu395.C, Phe400.C, Leu403.C
I -12.4 Ile235.B, Ile239.B, Ile398.B, Pro401.B, Leu402.B, Phe404.B, Gly405.B, Asn408.B
J -14.4 Ile239.B, Val243.B, Trp246.B, Phe298.C, Ile302.C, Ala305.C, Thr306.C, Tyr309.C
K -12.3 Trp246.C, Arg397.C, Ile398.C, Pro401.C, Leu402.C, Gly405.C, Asn408.C, Leu409.C
L -12.3 Ile235.D, Trp246.D, Ile398.D, Pro401.D, Leu402.D, Phe404.D, Gly405.D, Asn408.D
M -13.0 Ile239.D, Val243.D, Trp246.D, Phe298.E, Ile302.E, Ala305.E, Thr306.E, Tyr309.E
N -12.9 Val292.A, Ala295.A, Phe296.A, Ser299.A, Ile302.A, Glu303.A, Thr306.A, Ile392.A, Phe400.A, Leu403.A
O -12.7 Val292.E, Phe296.E, Ser299.E, Glu303.E, Thr306.E, Ile392.E, Leu395.E, Phe400.E, Leu403.E
P -12.5 Ile235.A, Trp246.A, Ile398.A, Pro401.A, Leu402.A, Phe404.A, Gly405.A, Asn408.A
Q -12.3 Ile235.E, Trp246.E, Ile398.E, Pro401.E, Leu402.E, Phe404.E, Gly405.E, Asn408.E
R -13.1 Ile239.A, Val243.A, Trp246.A, Phe298.B, Ile302.B, Ala305.B, Thr306.B, Tyr309.B
S -12.8 Phe298.A, Ile302.A, Thr306.A, Tyr309.A, Ile235.E, Met236.E, Ile239.E, Trp246.E
Hetero-pentameric GABAA chimeras
α5β3 GABAA plus GABA and nanobody, open state, human, 6a96
6a96_EC F -13.8 Ala286.A, Thr287.A, Asp290.A, Trp291.A, Ala294.A, Phe301.A, Leu223.E, Met227.E, Leu231.E, Ile234.E
G -13.9 Met283.D, Gly287.D, Val290.D, Leu294.D, Phe438.D, Tyr442.D, Tyr445.D, Tyr446.D
I -13.0 Trp237.B, Pro432.B, Ser436.B, Asn439.B, Leu440.B, Trp443.B, Leu444.B, Val447.B
J -12.8 Ile234.C, Trp237.C, Pro432.C, Phe435.C, Ser436.C, Asn439.C, Leu440.C, Trp443.C
M -12.8 Ile234.D, Trp237.D, Pro432.D, Phe435.D, Ser436.D, Asn439.D, Leu440.D, Trp443.D, Leu444.D, Val447.D
P -12.0 Met283.E, Phe291.E, Leu294.E, Thr434.E, Phe438.E, Val441.E, Tyr445.E, Tyr446.E
Q -12.5 Val230.A, Ile231.A, Leu235.A, Met239.A, Ile242.A, Val246.A, Met286.B, Phe293.B
R -13.0 Val230.A, Ile238.A, Ile242.A, Gln245.A, Pro403.A, Phe406.A, Gly407.A, Asn410.A, Trp414.A, Leu418.A
S -12.6 Ile234.E, Trp237.E, Pro432.E, Phe435.E, Ser436.E, Asn439.E, Leu440.E, Trp443.E
6a96_IC F -14.8 Leu231.D, Ile234.D, Val238.D, Trp241.D, Phe293.E, Leu297.E, Ala300.E, Phe301.E, Tyr304.E
G -15.1 Phe301.A, Ile305.A, Ala308.A, Thr309.A, Asn311.A, Tyr312.A, Leu231.E, Ile234.E, Val238.E, Trp241.E
H -13.8 Phe291.E, Leu294.E, Glu298.E, Phe301.E, Val302.E, Ile423.E, Val430.E, Phe431.E, Thr434.E
I -13.8 Phe291.C, Leu294.C, Glu298.C, Phe301.C, Val302.C, Ile423.C, Val430.C, Phe431.C, Thr434.C
J -13.7 Val295.A, Ala298.A, Phe299.A, Ser302.A, Ile305.A, Glu306.A, Thr309.A, Phe402.A
M -14.0 Leu231.C, Ile234.C, Val238.C, Trp241.C, Phe293.D, Leu297.D, Ala300.D, Phe301.D, Tyr304.D
N -14.0 Phe291.D, Leu294.D, Leu297.D, Glu298.D, Phe301.D, Val302.D, Ile423.D, Val430.D, Phe431.D, Thr434.D
P -12.7 Leu231.B, Ile234.B, Trp241.B, Phe293.C, Leu297.C, Ala300.C, Phe301.C, Tyr304.C
R -13.2 Ile230.B, Ile234.B, Trp237.B, Trp241.B, Arg428.B, Pro432.B, Phe435.B, Asn439.B
S -12.5 Trp426.C, Ile429.C, Val430.C, Phe433.C, Thr434.C, Leu437.C, Phe438.C, Val441.C
U -13.7 Phe291.B, Leu294.B, Glu298.B, Phe301.B, Ile423.B, Trp426.B, Val430.B, Phe431.B
V -12.6 Trp426.E, Ile429.E, Val430.E, Phe433.E, Thr434.E, Leu437.E, Phe438.E, Val441.E
α1β2γ2, plus GABA and antagonist, distorted state, conformation B, human, bound CHS, 6d6t
6d6t_EC F -15.7 Val263.B, Leu264.B, Thr267.B, Ile271.B, Arg274.B, Tyr294.B, Gln224.C, Pro228.C, Leu231.C, Ile232.C, Leu235.C, Thr256.C, Thr260.C, Ile264.C
G -15.0 Leu223.A, Gln224.A, Pro228.A, Leu231.A, Arg265.E, Leu268.E, Gly269.E, Thr272.E, Val273.E
H -14.3 Ala295.D, Ser299.D, Ile302.D, Tyr235.E, Phe236.E, Thr237.E, Ile238.E, Tyr241.E
M -15.2 Arg274.B, Asp287.B, Ala291.B, Tyr294.B, Ile302.B, Leu223.C, Gln224.C, Met227.C, Leu231.C
N -13.1 Ile223.B, Val227.B, Leu232.B, Ile235.B, Ile239.B, Pro330.B, Phe333.B, Asn337.B, Trp341.B
O -12.9 Ile218.A, Ile222.A, Ile230.A, Ile234.A, Trp237.A, Pro325.A, Phe328.A, Asn332.A, Trp336.A
Q -12.5 Ala283.B, Trp288.B, Ala291.B, Val292.B, Ala295.B, Phe296.B, Ser299.B, Leu332.B, Leu223.C
R -13.2 Ile235.D, Ile239.D, Pro330.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D, Leu345.D
S -13.3 Phe293.C, Met294.C, Leu297.C, Val227.D, Tyr231.D, Leu232.D, Ile235.D, Met236.D, Ile239.D, Trp341.D
6d6t_IC F -14.5 Val260.D, Leu264.D, Val253.E, Ile257.E, Asn258.E, Thr271.E, Leu274.E, Thr275.E, Thr278.E
G -14.3 Phe291.A, Met294.A, Glu298.A, Ala315.A, Ile316.A, Trp319.A, Ser320.A, Phe323.A, Phe324.A, Val327.A
H -14.0 Pro253.B, Thr256.B, Val257.B, Val260.B, Leu264.B, Ala249.C, Ala252.C, Thr256.C, Leu259.C, Leu274.E, Thr278.E
N -12.2 Phe296.D, Ser299.D, Ile302.D, Glu303.D, Thr306.D, Phe310.D, Ile321.D, Phe329.D, Leu332.D
P -15.0 Ser299.B, Glu303.B, Ile321.B, Leu324.B, Ser325.B, Ala328.B, Phe329.B, Leu332.B
Q -14.9 Thr256.B, Val260.B, Val263.B, Thr267.B, Tyr294.B, Phe298.B, Leu301.B, Pro228.C, Leu231.C, Ile232.C, Leu235.C, Val238.C, Leu253.C, Thr260.C
R -13.7 Tyr294.B, Phe298.B, Leu301.B, Ile302.B, Ala305.B, Leu231.C, Ile234.C, Val238.C
α1β2γ2, plus GABA and antagonist, distorted state, conformation A, human, bound CHS, 6d6u
6d6u_EC F -13.8 Arg274.D, Asp287.D, Ala291.D, Tyr294.D, Ala295.D, Phe298.D, Ile302.D, Gln239.E
G -13.6 Ile234.A, Trp237.A, Phe328.A, Ser329.A, Asn332.A, Ile333.A, Trp336.A, Leu337.A, Val340.A
H -13.3 Ile235.B, Ile239.B, Gln242.B, Pro330.B, Phe333.B, Asn337.B, Trp341.B, Leu345.B
M -13.0 Thr245.E, Val249.E, Phe343.E, Cys344.E, Asn347.E, Trp351.E, Tyr354.E, Leu355.E
P -12.7 Ile218.C, Ile222.C, Ile230.C, Trp237.C, Pro325.C, Ser329.C, Asn332.C, Trp336.C
Q -15.4 Val260.B, Val263.B, Thr267.B, Phe298.B, Leu301.B, Gln224.C, Pro228.C, Thr260.C, Ile264.C, His267.C, Leu268.C, Thr271.C
R -13.7 Ile235.D, Ile239.D, Pro330.D, Phe333.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D, Ala342.D, Leu345.D, Asn346.D
S -13.1 Arg274.B, Ala283.B, Asp287.B, Ala291.B, Tyr294.B, Phe298.B, Ile302.B, Leu223.C, Leu231.C
T -13.0 Phe293.C, Met294.C, Leu297.C, Val227.D, Leu232.D, Ile235.D, Met236.D, Ile239.D, Trp341.D, Leu345.D
6d6u_IC F -17.4 Pro228.A, Leu231.A, Ile232.A, Leu235.A, Leu253.A, Thr256.A, Ile264.A, Val302.E, Ile305.E, Phe306.E, Ser309.E, Glu313.E, Met331.E, Tyr334.E, Ala335.E, Phe338.E, Phe339.E, Ala342.E, Phe346.E
G -14.0 Val292.D, Ala295.D, Phe296.D, Ser299.D, Ile302.D, Glu303.D, Thr306.D, Phe310.D, Phe329.D
H -13.3 Thr256.D, Val260.D, Leu301.D, Ile302.D, Phe304.D, Ala305.D, Ile242.E, Leu246.E, Val249.E, Leu250.E, Val253.E
M -13.0 Leu231.A, Leu235.A, Val238.A, Ile242.A, Phe338.E, Ala342.E, Leu345.E, Phe346.E, Val349.E
N -12.7 Phe291.A, Arg312.A, Ile316.A, Trp319.A, Ser320.A, Phe323.A, Phe324.A, Val327.A, Phe331.A
O -13.5 Leu297.C, Ala300.C, Leu301.C, Tyr304.C, Ile305.C, Ile239.D, Val243.D, Trp246.D
P -12.5 Ile230.C, Ile234.C, Trp237.C, Trp241.C, Arg318.C, Arg321.C, Ile322.C, Pro325.C
Q -12.8 Trp246.D, Arg326.D, Ile327.D, Pro330.D, Leu331.D, Gly334.D, Ile335.D, Leu338.D
R -15.0 Val252.B, Thr256.B, Val260.B, Leu301.B, Phe304.B, Ala305.B, Asn308.B, Leu235.C, Thr260.C, Ile264.C, Ile270.E, Leu274.E
S -14.2 Val290.C, Phe291.C, Met294.C, Glu298.C, Ile316.C, Trp319.C, Ser320.C, Phe323.C, Phe324.C, Val327.C
T -13.9 Val292.D, Phe296.D, Ser299.D, Glu303.D, Ile321.D, Leu324.D, Ser325.D, Ala328.D, Phe329.D, Leu332.D
U -15.0 Tyr294.B, Phe298.B, Leu301.B, Ile302.B, Ala305.B, Thr306.B, Tyr309.B, Leu231.C, Leu235.C, Val238.C
V -13.3 Ala295.B, Ser299.B, Ile302.B, Glu303.B, Thr306.B, Lys320.B, Ile321.B, Asp322.B, Leu324.B, Ser325.B, Phe329.B
α1β3γ2, plus toxin PTX, closed/resting state, human, 6hug
6hug_EC F -14.2 Trp288.A, Val292.A, Phe400.A, Leu403.A, Phe407.A, Val410.A, Thr414.A, Tyr415.A, Arg418.A
H -14.1 Met283.B, Thr434.B, Leu437.B, Phe438.B, Val441.B, Tyr442.B, Tyr445.B, Tyr446.B
I -13.7 Ile223.A, Val227.A, Leu232.A, Ile235.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Leu409.A, Trp412.A, Leu416.A
J -13.6 Met233.C, Thr237.C, Tyr241.C, Thr245.C, Val249.C, Trp252.C, Pro419.C, Cys423.C, Asn426.C, Trp430.C, Leu434.C
K -12.9 Ile230.B, Ile234.B, Trp237.B, Pro432.B, Phe435.B, Ser436.B, Asn439.B, Leu440.B, Trp443.B, Leu444.B, Val447.B
L -12.7 Ile228.A, Leu232.A, Val278.B, Met283.B, Met286.B, Val290.B, Leu294.B, Thr434.B
M -13.3 Thr420.C, Cys423.C, Leu424.C, Asn426.C, Leu427.C, Trp430.C, Leu434.C, Tyr435.C
P -14.1 Met283.E, Phe433.E, Thr434.E, Leu437.E, Phe438.E, Val441.E, Tyr442.E, Tyr445.E, Tyr446.E
Q -13.5 Ile223.D, Val227.D, Ile235.D, Pro401.D, Leu402.D, Gly405.D, Asn408.D, Trp412.D
R -13.4 Ile234.E, Trp237.E, Pro432.E, Phe435.E, Ser436.E, Asn439.E, Leu440.E, Trp443.E, Leu444.E, Val447.E
S -13.1 Trp288.A, Ala291.A, Val292.A, Ala295.A, Ser299.A, Gly219.E, Ile222.E, Leu223.E, Met227.E
6hug_IC F -14.7 Ile235.A, Ile239.A, Val243.A, Trp246.A, Asn408.A, Leu297.B, Ala300.B, Phe301.B, Tyr304.B
H -13.8 Val249.C, Trp252.C, Val253.C, Trp256.C, Phe298.D, Ile302.D, Ala305.D, Thr306.D, Tyr309.D
I -13.2 Ile230.B, Ile234.B, Trp237.B, Trp241.B, Pro432.B, Phe435.B, Ser436.B, Asn439.B, Thr316.C, Tyr319.C, Phe320.C
K -12.5 Trp246.A, Arg397.A, Ile398.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Leu409.A
L -14.3 Ile239.D, Val243.D, Trp246.D, Leu297.E, Ala300.E, Phe301.E, Tyr304.E, Ile305.E
M -14.1 Leu246.C, Ala295.D, Phe298.D, Ser299.D, Ile302.D, Glu303.D, Thr306.D, Ile392.D, Phe400.D
α1β3γ2, plus GABA and toxin PTX, closed/resting state, human, 6huj
6huj_EC F -13.8 Trp288.A, Val292.A, Leu403.A, Phe407.A, Val410.A, Thr414.A, Tyr415.A, Arg418.A
H -13.5 Ile223.D, Val227.D, Tyr231.D, Leu232.D, Ile235.D, Ile239.D, Pro401.D, Asn408.D, Trp412.D, Leu416.D
I -13.3 Met233.C, Thr237.C, Tyr241.C, Ile242.C, Thr245.C, Val249.C, Trp252.C, Pro419.C, Phe422.C, Cys423.C, Trp430.C
J -13.7 Trp288.D, Val292.D, Leu403.D, Phe407.D, Val410.D, Tyr411.D, Thr414.D, Tyr415.D
K -13.1 Ile218.E, Ile222.E, Ile230.E, Ile234.E, Trp237.E, Pro432.E, Phe435.E, Ser436.E, Asn439.E, Trp443.E
L -12.9 Met283.E, Gly287.E, Val290.E, Leu294.E, Phe438.E, Val441.E, Tyr445.E, Tyr446.E
O -13.8 Ile223.A, Val227.A, Leu232.A, Ile235.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Trp412.A, Leu416.A
P -13.7 Met283.B, Thr434.B, Leu437.B, Phe438.B, Val441.B, Tyr442.B, Tyr445.B, Tyr446.B
Q -13.6 Ile218.B, Ile222.B, Met227.B, Ile230.B, Pro432.B, Phe433.B, Ser436.B, Asn439.B, Trp443.B
R -13.6 Thr420.C, Cys423.C, Asn426.C, Leu427.C, Trp430.C, Val431.C, Leu434.C, Tyr435.C
S -13.6 Leu298.C, Phe417.C, Thr420.C, Ala421.C, Leu424.C, Phe425.C, Val428.C, Tyr429.C, Tyr433.C
6huj_IC F -14.4 Val249.C, Trp252.C, Val253.C, Trp256.C, Phe422.C, Cys423.C, Asn426.C, Ala305.D, Thr306.D, Tyr309.D, Phe310.D
H -14.4 Ile239.D, Val243.D, Trp246.D, Pro401.D, Phe404.D, Gly405.D, Asn408.D, Leu297.E, Ala300.E, Phe301.E, Tyr304.E, Ile305.E
I -13.2 Phe298.A, Ile302.A, Ala305.A, Thr306.A, Tyr309.A, Ile234.E, Trp237.E, Val238.E, Trp241.E
K -12.6 Leu231.B, Ile305.C, Phe308.C, Ser309.C, Arg406.C, Ile407.C, Met410.C, Tyr413.C, Phe418.C
L -12.8 Met227.B, Ile230.B, Leu231.B, Ile234.B, Trp237.B, Trp241.B, Thr316.C, Tyr319.C, Phe320.C
N -14.3 Ile235.A, Ile239.A, Val243.A, Trp246.A, Leu297.B, Ala300.B, Phe301.B, Tyr304.B
O -13.1 Trp246.A, Arg397.A, Ile398.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Leu409.A
P -12.9 Trp237.B, Trp241.B, Arg428.B, Ile429.B, Pro432.B, Phe433.B, Ser436.B, Asn439.B
α1β3γ2, plus antagonist bicuculline, closed state, human, 6huk
6huk_EC F -13.6 Met233.C, Thr237.C, Thr245.C, Val249.C, Trp252.C, Pro419.C, Phe422.C, Cys423.C, Asn426.C, Trp430.C
I -13.2 Ile223.A, Val227.A, Ile235.A, Ile239.A, Pro401.A, Phe404.A, Asn408.A, Trp412.A, Leu416.A
J -13.2 Trp288.A, Val292.A, Leu403.A, Phe407.A, Val410.A, Thr414.A, Tyr415.A, Arg418.A
N -12.8 Thr237.C, Ile238.C, Ile242.C, Leu246.C, Ala283.D, Trp288.D, Ala291.D, Ala295.D, Phe298.D, Ser299.D, Ile302.D
O -14.3 Met283.E, Phe433.E, Thr434.E, Leu437.E, Phe438.E, Val441.E, Tyr445.E, Tyr446.E
P -14.1 Trp288.D, Val292.D, Ser299.D, Phe400.D, Leu403.D, Phe407.D, Val410.D, Thr414.D, Tyr415.D, Arg418.D
Q -13.6 Trp237.E, Pro432.E, Phe435.E, Ser436.E, Asn439.E, Trp443.E, Leu444.E, Val447.E
R -13.7 Ala283.A, Trp288.A, Ala291.A, Val292.A, Ala295.A, Phe296.A, Ser299.A, Leu403.A, Leu223.E
S -12.9 Ile239.D, Pro401.D, Phe404.D, Gly405.D, Asn408.D, Leu409.D, Trp412.D, Leu416.D
6huk_IC F -13.5 Met236.A, Ile239.A, Val243.A, Trp246.A, Phe293.B, Leu297.B, Phe301.B, Tyr304.B
H -13.5 Leu246.C, Val249.C, Trp252.C, Trp256.C, Phe298.D, Ile302.D, Ala305.D, Thr306.D, Tyr309.D
J -13.1 Leu231.B, Ile305.C, Phe308.C, Ser309.C, Val312.C, Glu313.C, Thr316.C, Ile407.C, Met410.C, Tyr413.C, Phe417.C, Phe418.C
K -12.7 Met227.B, Leu231.B, Ile234.B, Trp241.B, Ile305.C, Phe308.C, Val312.C, Thr316.C, Tyr319.C, Phe320.C
L -12.5 Ser299.A, Glu303.A, Ile392.A, Leu395.A, Ser396.A, Ala399.A, Phe400.A, Leu403.A
N -12.3 Val302.C, Ile305.C, Phe306.C, Ser309.C, Glu313.C, Thr316.C, Phe320.C, Ile407.C, Met410.C, Phe417.C, Phe418.C
O -13.5 Trp246.D, Arg397.D, Ile398.D, Pro401.D, Leu402.D, Gly405.D, Asn408.D, Leu409.D
P -13.3 Ile235.D, Ile239.D, Val243.D, Trp246.D, Leu297.E, Ala300.E, Phe301.E, Tyr304.E, Ile305.E
Q -13.3 Leu246.C, Ala295.D, Phe298.D, Ser299.D, Ile302.D, Glu303.D, Thr306.D, Ile392.D, Phe400.D
α1β3γ2, plus GABA and alprazolam, desensitized state, human, 6huo
6huo_EC F -13.8 Ile234.E, Trp237.E, Pro432.E, Phe435.E, Ser436.E, Asn439.E, Leu440.E, Trp443.E, Leu444.E, Val447.E
H -14.1 Val249.C, Trp252.C, Pro419.C, Cys423.C, Asn426.C, Trp430.C, Leu434.C, Tyr435.C
I -13.6 Met233.C, Thr237.C, Tyr241.C, Ile242.C, Thr245.C, Trp252.C, Pro419.C, Phe422.C, Cys423.C, Trp430.C
J -13.5 Val227.A, Leu232.A, Ile235.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Trp412.A
K -13.4 Trp288.A, Val292.A, Phe400.A, Leu403.A, Phe407.A, Val410.A, Thr414.A, Tyr415.A, Arg418.A
L -13.4 Ile218.B, Ile230.B, Trp237.B, Pro432.B, Phe435.B, Ser436.B, Asn439.B, Trp443.B, Val447.B
M -12.4 Met283.B, Phe433.B, Thr434.B, Leu437.B, Phe438.B, Val441.B, Tyr442.B, Tyr445.B, Tyr446.B
N -12.4 Val278.B, Met283.B, Met286.B, Gly287.B, Val290.B, Phe291.B, Leu294.B, Thr434.B
O -13.2 Thr237.C, Ile238.C, Ile242.C, Leu246.C, Val249.C, Ala283.D, Trp288.D, Phe298.D
R -13.5 Ile223.D, Val227.D, Leu232.D, Ile235.D, Pro401.D, Leu402.D, Gly405.D, Asn408.D, Trp412.D
S -13.3 Trp288.D, Val292.D, Leu403.D, Phe407.D, Val410.D, Thr414.D, Tyr415.D, Arg418.D
6huo_IC F -15.5 Ile239.A, Val243.A, Trp246.A, Pro401.A, Phe404.A, Asn408.A, Leu297.B, Ala300.B, Phe301.B, Val302.B, Tyr304.B
H -13.3 Met227.B, Leu231.B, Ile234.B, Trp241.B, Ile305.C, Phe308.C, Val312.C, Thr316.C, Phe320.C
I -12.8 Val302.C, Ile305.C, Ser309.C, Val312.C, Glu313.C, Thr316.C, Phe320.C, Ile407.C, Met410.C, Phe418.C
K -13.6 Ile230.B, Ile234.B, Trp237.B, Trp241.B, Arg428.B, Ile429.B, Pro432.B, Ser436.B, Asn439.B
α1β3γ2, plus GABA and valium, desensitized state, human, 6hup
6hup_EC F -14.5 Trp288.D, Val292.D, Ser299.D, Phe400.D, Leu403.D, Phe407.D, Val410.D, Thr414.D, Tyr415.D, Arg418.D
H -13.6 Ile218.B, Ile222.B, Ile230.B, Pro432.B, Phe433.B, Ser436.B, Asn439.B, Trp443.B
I -13.6 Ile223.A, Val227.A, Leu232.A, Ile235.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Trp412.A
J -13.2 Met233.C, Thr237.C, Tyr241.C, Ile242.C, Thr245.C, Pro419.C, Phe422.C, Cys423.C, Trp430.C
K -14.3 Thr420.C, Cys423.C, Asn426.C, Leu427.C, Trp430.C, Val431.C, Leu434.C, Tyr435.C
L -13.2 Trp288.A, Val292.A, Leu403.A, Phe407.A, Val410.A, Tyr411.A, Thr414.A, Tyr415.A
N -12.3 Leu298.C, Val302.C, Ile305.C, Phe306.C, Ser309.C, Phe417.C, Phe418.C, Phe425.C, Val428.C, Tyr433.C
P -11.9 Ile222.B, Leu223.B, Met227.B, Leu231.B, Val293.C, Ile305.C, Phe308.C, Val312.C
Q -13.9 Ile234.E, Trp237.E, Pro432.E, Phe435.E, Ser436.E, Asn439.E, Leu440.E, Trp443.E, Leu444.E, Val447.E
R -13.6 Ile238.C, Ile242.C, Leu246.C, Ala283.D, Trp288.D, Ala291.D, Val292.D, Tyr294.D, Ala295.D, Phe298.D, Ser299.D, Ile302.D
S -13.3 Val227.D, Leu232.D, Ile235.D, Pro401.D, Leu402.D, Gly405.D, Asn408.D, Leu409.D, Trp412.D, Leu416.D
U -12.7 Ala283.A, Trp288.A, Ala291.A, Val292.A, Ala295.A, Phe298.A, Ser299.A, Ile302.A, Leu223.E, Met227.E, Leu231.E
6hup_IC F -14.4 Ile239.A, Val243.A, Trp246.A, Pro401.A, Leu297.B, Ala300.B, Phe301.B, Val302.B, Tyr304.B
H -12.9 Thr245.C, Val249.C, Trp252.C, Trp256.C, Phe422.C, Ile302.D, Ala305.D, Thr306.D, Tyr309.D
I -12.9 Ile234.B, Trp241.B, Ile305.C, Phe308.C, Val312.C, Thr316.C, Tyr319.C, Phe320.C
J -12.8 Ile230.B, Ile234.B, Trp237.B, Trp241.B, Pro432.B, Phe435.B, Ser436.B, Asn439.B, Thr316.C, Tyr319.C, Phe320.C
K -12.8 Thr245.C, Leu246.C, Val249.C, Trp252.C, Trp256.C, Arg415.C, Ile416.C, Pro419.C, Phe422.C
L -12.7 Leu231.B, Ile305.C, Phe308.C, Ser309.C, Val312.C, Glu313.C, Thr316.C, Phe320.C, Ile407.C, Met410.C
M -14.6 Val302.C, Ile305.C, Phe306.C, Ser309.C, Glu313.C, Ile407.C, Met410.C, Tyr413.C, Phe417.C, Phe418.C
N -12.9 Trp246.A, Arg397.A, Ile398.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Leu409.A
α1β3γ2, plus positive allosteric modulator, desensitized conformation, with resolved phospholipids, human, 6i53
6i53_EC F -14.0 Trp288.A, Val292.A, Leu403.A, Phe407.A, Val410.A, Tyr411.A, Thr414.A, Tyr415.A
H -13.6 Met283.E, Phe433.E, Thr434.E, Leu437.E, Phe438.E, Val441.E, Tyr442.E, Tyr445.E, Tyr446.E
I -13.4 Met233.C, Thr237.C, Tyr241.C, Ile242.C, Thr245.C, Pro419.C, Phe422.C, Cys423.C, Asn426.C, Trp430.C
J -13.4 Ile223.D, Val227.D, Leu232.D, Ile235.D, Pro401.D, Leu402.D, Gly405.D, Asn408.D, Trp412.D
K -13.2 Trp288.D, Val292.D, Leu403.D, Phe407.D, Val410.D, Tyr411.D, Thr414.D, Tyr415.D
L -13.0 Ile234.E, Trp237.E, Pro432.E, Phe435.E, Ser436.E, Asn439.E, Leu440.E, Trp443.E, Leu444.E, Val447.E
M -13.3 Ile238.C, Ile242.C, Leu246.C, Ala283.D, Trp288.D, Ala291.D, Tyr294.D, Ala295.D, Phe298.D, Ser299.D, Ile302.D
N -13.2 Pro419.C, Thr420.C, Cys423.C, Asn426.C, Leu427.C, Trp430.C, Val431.C, Tyr435.C
O -13.3 Ile234.B, Trp237.B, Pro432.B, Phe435.B, Ser436.B, Asn439.B, Leu440.B, Trp443.B, Leu444.B, Val447.B
P -13.2 Ile223.A, Val227.A, Leu232.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Leu409.A, Trp412.A
Q -12.8 Met283.B, Phe433.B, Thr434.B, Leu437.B, Phe438.B, Val441.B, Tyr442.B, Tyr445.B, Tyr446.B
R -12.6 Val278.B, Met283.B, Met286.B, Gly287.B, Val290.B, Phe291.B, Leu294.B, Phe431.B, Thr434.B
6i53_IC F -15.3 Ala295.D, Ser299.D, Glu303.D, Ile392.D, Leu395.D, Ser396.D, Ala399.D, Phe400.D, Leu403.D
H -14.9 Ile235.A, Ile239.A, Trp246.A, Asn408.A, Leu297.B, Ala300.B, Phe301.B, Tyr304.B
I -14.5 Ala295.A, Ser299.A, Glu303.A, Ile392.A, Leu395.A, Ser396.A, Ala399.A, Phe400.A, Leu403.A
J -14.4 Ile239.D, Val243.D, Trp246.D, Pro401.D, Phe404.D, Gly405.D, Asn408.D, Leu297.E, Ala300.E, Phe301.E, Tyr304.E
K -13.6 Thr245.C, Val249.C, Trp252.C, Trp256.C, Phe422.C, Cys423.C, Asn426.C, Ile302.D, Thr306.D
L -13.1 Pro415.B, Trp426.B, Val430.B, Phe433.B, Thr434.B, Leu437.B, Phe438.B, Val441.B
M -12.9 Met227.B, Leu231.B, Ile305.C, Phe308.C, Ser309.C, Val312.C, Thr316.C, Met410.C
N -12.9 Thr245.C, Leu246.C, Val249.C, Trp252.C, Trp256.C, Arg415.C, Ile416.C, Pro419.C, Phe422.C, Cys423.C
P -13.2 Trp246.A, Arg397.A, Ile398.A, Pro401.A, Leu402.A, Gly405.A, Asn408.A, Leu409.A
α1β2γ2, plus bicucculine, resting/closed conformation, human, 6x3s
6x3s_EC F -14.5 Trp288.D, Val292.D, Leu332.D, Phe336.D, Val339.D, Tyr340.D, Thr343.D, Tyr344.D, Arg347.D
G -14.1 Ala285.B, Trp288.B, Val292.B, Leu332.B, Ile335.B, Phe336.B, Val339.B, Tyr340.B, Thr343.B, Tyr344.B
H -13.3 Ile223.B, Val227.B, Ile235.B, Pro330.B, Gly334.B, Asn337.B, Trp341.B, Leu345.B
M -13.1 Ala283.B, Trp288.B, Ala291.B, Ala295.B, Phe298.B, Ser299.B, Ile302.B, Gly219.C, Ile222.C, Leu223.C, Met227.C, Leu231.C, Ile234.C
N -13.0 Met283.C, Val327.C, Phe330.C, Phe331.C, Val334.C, Tyr335.C, Tyr338.C, Tyr339.C
O -12.8 Ile222.C, Ile230.C, Ile234.C, Trp237.C, Pro325.C, Phe328.C, Asn332.C, Ile333.C, Trp336.C
P -14.8 Met283.A, Val327.A, Phe330.A, Phe331.A, Val334.A, Tyr335.A, Tyr338.A, Tyr339.A
Q -14.4 Met233.E, Thr237.E, Tyr241.E, Ile242.E, Thr245.E, Val249.E, Trp252.E, Pro340.E, Cys344.E, Asn347.E, Trp351.E
R -13.2 Leu145.A, Ile230.A, Trp237.A, Pro325.A, Ser329.A, Asn332.A, Ile333.A, Trp336.A, Val340.A
S -12.7 Leu298.E, Val302.E, Phe306.E, Phe338.E, Ala342.E, Phe346.E, Val349.E, Ser353.E, Tyr354.E
6x3s_IC F -14.5 Val292.B, Ala295.B, Ser299.B, Glu303.B, Ile321.B, Leu324.B, Ser325.B, Ala328.B, Phe329.B, Leu332.B
G -13.4 Phe293.A, Leu297.A, Ala300.A, Leu301.A, Tyr304.A, Leu232.B, Ile235.B, Ile239.B, Val243.B, Trp246.B, Asn337.B
M -12.7 Phe293.C, Leu297.C, Leu301.C, Tyr304.C, Ile235.D, Ile239.D, Val243.D, Trp246.D, Asn337.D
P -12.9 Ile230.A, Trp237.A, Trp241.A, Ile322.A, Pro325.A, Phe328.A, Ser329.A, Asn332.A
R -14.3 Phe298.D, Ile302.D, Ala305.D, Thr306.D, Tyr309.D, Thr245.E, Val249.E, Trp252.E, Val253.E, Trp256.E, Pro340.E, Asn347.E
S -13.6 Val302.E, Ile305.E, Phe306.E, Ser309.E, Glu313.E, Thr316.E, Phe320.E, Met331.E, Phe338.E, Phe339.E
T -13.6 Leu231.A, Ile234.A, Trp241.A, Ile305.E, Phe308.E, Val312.E, Thr316.E, Tyr319.E
α1β2γ2, plus GABA  and propofol, desensitized conformation, human, 6x3t
6x3t_EC F -14.9 Ser270.B, Arg274.B, Asp287.B, Ile290.B, Ala291.B, Tyr294.B, Ala295.B, Ile302.B, Leu223.C, Met227.C, Leu231.C
G -14.6 Trp288.B, Val292.B, Leu332.B, Ile335.B, Phe336.B, Val339.B, Tyr340.B, Tyr344.B, Arg347.B
H -14.6 Trp288.D, Val292.D, Phe296.D, Leu332.D, Phe336.D, Val339.D, Thr343.D, Tyr344.D, Arg347.D
M -14.4 Met283.C, Val327.C, Phe330.C, Phe331.C, Val334.C, Tyr335.C, Tyr338.C, Tyr339.C
N -14.1 Phe323.A, Val327.A, Phe330.A, Phe331.A, Val334.A, Tyr335.A, Tyr338.A, Tyr339.A
O -13.4 Ile218.A, Ile222.A, Met227.A, Ile230.A, Trp237.A, Pro325.A, Ser329.A, Asn332.A, Trp336.A, Val340.A
P -13.8 Ile218.C, Ile222.C, Met227.C, Ile230.C, Trp237.C, Pro325.C, Phe328.C, Ser329.C, Asn332.C, Trp336.C
Q -12.9 Met233.E, Thr237.E, Tyr241.E, Ile242.E, Thr245.E, Pro340.E, Cys344.E, Asn347.E, Trp351.E
R -13.5 Val227.B, Ile235.B, Pro330.B, Leu331.B, Gly334.B, Asn337.B, Leu338.B, Trp341.B, Leu345.B
S -13.5 Ile235.D, Ile239.D, Pro330.D, Phe333.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D, Leu345.D
U -12.9 Ala283.D, Trp288.D, Ala291.D, Phe298.D, Ile302.D, Ile238.E, Ile242.E, Leu246.E, Val249.E
V -12.4 Leu298.E, Val302.E, Ile305.E, Ser309.E, Phe338.E, Phe346.E, Val349.E, Tyr350.E, Ser353.E, Tyr354.E
6x3t_IC F -13.7 Phe298.D, Ile302.D, Ala305.D, Thr306.D, Tyr309.D, Val249.E, Val253.E, Trp256.E
G -14.2 Val292.D, Ala295.D, Phe296.D, Ser299.D, Glu303.D, Ile321.D, Leu324.D, Ser325.D, Ala328.D, Phe329.D, Leu332.D
H -13.7 Ala295.B, Ser299.B, Glu303.B, Ile321.B, Leu324.B, Ser325.B, Ala328.B, Phe329.B, Leu332.B
M -13.7 Phe293.A, Leu297.A, Ala300.A, Leu301.A, Tyr304.A, Ile239.B, Val243.B, Trp246.B
N -13.5 Phe298.B, Ile302.B, Ala305.B, Thr306.B, Tyr309.B, Met227.C, Ile234.C, Val238.C, Trp241.C
O -14.0 Leu297.C, Ala300.C, Leu301.C, Tyr304.C, Ile235.D, Ile239.D, Val243.D, Trp246.D
Q -13.0 Ile235.B, Ile239.B, Trp246.B, Ile327.B, Pro330.B, Leu331.B, Gly334.B, Asn337.B
R -13.0 Val290.A, Phe291.A, Met294.A, Glu298.A, Leu301.A, Ile316.A, Trp319.A, Phe323.A, Val327.A, Phe330.A, Phe331.A
S -13.6 Ile305.E, Ser309.E, Val312.E, Glu313.E, Met331.E, Tyr334.E, Ala335.E, Phe338.E, Phe339.E
V -13.1 Ile230.A, Ile234.A, Trp237.A, Trp241.A, Phe328.A, Thr316.E, Tyr319.E, Phe320.E
α1β2γ2, plus GABA  and flumazenil, desensitized conformation, human, 6x3u
6x3u_EC F -14.8 Ser270.D, Arg274.D, Asp287.D, Trp288.D, Ile290.D, Ala291.D, Tyr294.D, Ala295.D, Phe298.D, Ile302.D, Ile238.E, Ile242.E, Leu246.E
G -14.3 Trp288.B, Val292.B, Phe296.B, Leu332.B, Phe336.B, Val339.B, Tyr340.B, Thr343.B, Tyr344.B, Arg347.B
H -14.3 Trp288.D, Val292.D, Phe296.D, Leu332.D, Phe336.D, Val339.D, Tyr340.D, Thr343.D, Tyr344.D, Arg347.D
M -13.4 Ile239.B, Pro330.B, Phe333.B, Gly334.B, Asn337.B, Leu338.B, Trp341.B, Leu345.B
N -13.5 Leu298.E, Val302.E, Ile305.E, Ser309.E, Phe346.E, Val349.E, Tyr350.E, Ser353.E, Tyr354.E
O -13.0 Phe293.A, Leu297.A, Ile223.B, Val227.B, Leu232.B, Ile235.B, Met236.B, Ile239.B
P -12.8 Phe298.D, Met233.E, Thr237.E, Tyr241.E, Ile242.E, Thr245.E, Val249.E, Trp351.E
Q -12.5 Ile218.A, Ile222.A, Ile230.A, Pro325.A, Ser329.A, Asn332.A, Ile333.A, Trp336.A, Val340.A
S -13.6 Ile239.D, Pro330.D, Phe333.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D, Ala342.D, Leu345.D
T -12.7 Ile218.C, Ile222.C, Ile230.C, Ile234.C, Trp237.C, Pro325.C, Asn332.C, Trp336.C
U -12.5 Ala283.B, Trp288.B, Ala291.B, Ala295.B, Phe298.B, Ser299.B, Ile302.B, Leu223.C, Met227.C
6x3u_IC F -16.0 Ile302.B, Ala305.B, Thr306.B, Tyr309.B, Ile230.C, Ile234.C, Trp237.C, Val238.C, Trp241.C, Phe328.C
G -14.6 Val302.E, Ile305.E, Phe306.E, Ser309.E, Glu313.E, Met331.E, Tyr334.E, Ala335.E, Phe338.E, Phe339.E, Ala342.E
H -13.5 Ile230.A, Ile234.A, Trp237.A, Trp241.A, Val312.E, Thr316.E, Tyr319.E, Phe320.E
M -13.0 Phe293.A, Leu297.A, Ala300.A, Leu301.A, Tyr304.A, Met236.B, Ile239.B, Val243.B, Trp246.B
N -12.9 Thr306.D, Phe310.D, Thr245.E, Val249.E, Trp252.E, Trp256.E, Phe343.E, Cys344.E
O -13.7 Val292.D, Ala295.D, Phe296.D, Ser299.D, Ile302.D, Glu303.D, Thr306.D, Phe310.D, Leu332.D
P -12.2 Ile235.D, Ile239.D, Trp246.D, Ile327.D, Pro330.D, Phe333.D, Gly334.D, Asn337.D
R -12.9 Ala295.B, Phe298.B, Ser299.B, Ile302.B, Glu303.B, Thr306.B, Phe310.B, Ile321.B, Leu231.C
S -12.8 Phe293.C, Leu297.C, Ala300.C, Leu301.C, Tyr304.C, Ile239.D, Val243.D, Trp246.D, Leu247.D
T -12.4 Phe296.B, Ser299.B, Ile302.B, Glu303.B, Thr306.B, Phe310.B, Ile321.B, Phe329.B, Leu332.B, Phe336.B
α1β2γ2, plus GABA  and etomidate, desensitized conformation, human, 6x3v
6x3v_EC F -14.0 Leu298.E, Phe338.E, Ala342.E, Leu345.E, Phe346.E, Val349.E, Tyr350.E, Ser353.E, Tyr354.E
G -14.7 Ala285.B, Trp288.B, Val292.B, Leu332.B, Ile335.B, Phe336.B, Val339.B, Tyr340.B, Thr343.B, Tyr344.B
H -14.5 Trp288.D, Val292.D, Leu332.D, Phe336.D, Val339.D, Tyr340.D, Tyr344.D, Arg347.D
M -14.4 Trp288.D, Val292.D, Ala295.D, Phe296.D, Phe336.D, Val339.D, Thr343.D, Tyr344.D, Arg347.D
N -13.5 Ile235.B, Ile239.B, Pro330.B, Phe333.B, Gly334.B, Asn337.B, Leu338.B, Trp341.B, Leu345.B
O -13.4 Ile235.D, Ile239.D, Pro330.D, Phe333.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D, Leu345.D
P -13.2 Ile218.C, Ile222.C, Ile230.C, Ile234.C, Trp237.C, Pro325.C, Ser329.C, Asn332.C, Trp336.C
Q -13.1 Met283.C, Val290.C, Phe291.C, Met294.C, Val327.C, Phe331.C, Val334.C, Tyr338.C
R -12.8 Ala283.B, Trp288.B, Ala291.B, Ala295.B, Phe298.B, Ser299.B, Ile302.B, Ile222.C, Leu223.C, Met227.C, Leu231.C
S -13.5 Ser270.D, Arg274.D, Asp287.D, Trp288.D, Ala291.D, Tyr294.D, Ala295.D, Phe298.D, Ile238.E, Ile242.E, Leu246.E
T -13.3 Met233.E, Thr237.E, Tyr241.E, Ile242.E, Thr245.E, Leu246.E, Val249.E, Trp351.E, Leu355.E
U -12.8 Ile222.A, Ile230.A, Trp237.A, Pro325.A, Ser329.A, Asn332.A, Ile333.A, Trp336.A, Val340.A
6x3v_IC F -14.6 Val302.E, Ile305.E, Phe306.E, Ser309.E, Glu313.E, Thr316.E, Phe320.E, Met331.E, Phe338.E, Phe339.E, Phe346.E
G -13.6 Ser299.D, Glu303.D, Ile321.D, Leu324.D, Ser325.D, Ala328.D, Phe329.D, Leu332.D
H -13.3 Val292.B, Phe296.B, Ser299.B, Glu303.B, Thr306.B, Ile321.B, Ser325.B, Phe329.B, Leu332.B
M -12.9 Val290.C, Phe291.C, Met294.C, Leu301.C, Ile316.C, Trp319.C, Phe324.C, Val327.C, Phe331.C
N -12.8 Phe298.B, Ile302.B, Ala305.B, Thr306.B, Tyr309.B, Ile230.C, Leu231.C, Ile234.C, Trp241.C
O -14.2 Tyr294.B, Ala295.B, Phe298.B, Ser299.B, Ile302.B, Thr306.B, Arg317.B, Leu231.C
P -13.2 Phe291.A, Met294.A, Glu298.A, Leu301.A, Ile316.A, Trp319.A, Phe323.A, Phe324.A, Val327.A, Phe331.A
Q -13.7 Met227.A, Leu231.A, Ile234.A, Trp241.A, Ile305.E, Phe308.E, Val312.E, Thr316.E
R -13.8 Ile230.A, Ile234.A, Trp237.A, Trp241.A, Arg321.A, Ile322.A, Pro325.A, Phe328.A, Ser329.A, Asn332.A
S -13.4 Phe298.D, Ile302.D, Thr306.D, Val249.E, Trp252.E, Trp256.E, Pro340.E, Phe343.E, Cys344.E
α1β2γ2, plus GABA  and phenobarbital, desensitized conformation, human, 6x3w
6x3w_EC F -16.2 Ser270.B, Arg274.B, Asp287.B, Ile290.B, Ala291.B, Tyr294.B, Ala295.B, Phe298.B, Ser299.B, Leu223.C, Met227.C, Pro228.C, Leu231.C
G -15.1 Trp288.D, Val292.D, Leu332.D, Phe336.D, Tyr340.D, Thr343.D, Tyr344.D, Arg347.D
H -14.9 Ala285.B, Trp288.B, Leu332.B, Ile335.B, Phe336.B, Val339.B, Tyr340.B, Thr343.B, Tyr344.B
M -15.3 Met233.E, Gly234.E, Thr237.E, Tyr241.E, Ile242.E, Cys344.E, Asn347.E, Trp351.E
N -13.6 Tyr282.D, Ala283.D, Trp288.D, Thr237.E, Ile238.E, Ile242.E, Val249.E, Trp252.E
O -13.6 Ile223.D, Val227.D, Ile235.D, Pro330.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D, Leu345.D
P -13.4 Ile222.C, Ile230.C, Ile234.C, Trp237.C, Pro325.C, Phe328.C, Ser329.C, Asn332.C, Trp336.C
Q -13.1 Phe293.A, Ile223.B, Val227.B, Tyr231.B, Leu232.B, Ile235.B, Ile239.B, Trp341.B, Leu345.B
R -13.1 Ile223.B, Val227.B, Ile235.B, Pro330.B, Leu331.B, Gly334.B, Asn337.B, Leu338.B, Trp341.B
T -13.2 Met283.A, Val290.A, Phe291.A, Met294.A, Val327.A, Phe331.A, Val334.A, Tyr338.A
U -13.0 Leu298.E, Val302.E, Phe306.E, Ala342.E, Leu345.E, Phe346.E, Val349.E, Tyr350.E, Ser353.E, Tyr354.E
6x3w_IC F -13.4 Ile230.A, Ile234.A, Trp237.A, Val238.A, Trp241.A, Asn332.A, Val312.E, Thr316.E, Phe320.E
G -13.1 Phe298.B, Ile302.B, Thr306.B, Tyr309.B, Ile230.C, Ile234.C, Val238.C, Trp241.C
H -12.9 Val292.B, Ala295.B, Ser299.B, Glu303.B, Thr306.B, Ile321.B, Ser325.B, Phe329.B, Leu332.B
N -14.0 Met227.A, Leu231.A, Ile305.E, Phe308.E, Ser309.E, Val312.E, Glu313.E, Thr316.E, Met331.E
O -13.2 Met294.A, Glu298.A, Leu301.A, Ile316.A, Trp319.A, Phe323.A, Phe324.A, Val327.A, Phe331.A
P -12.8 Phe293.A, Leu297.A, Leu301.A, Ile235.B, Met236.B, Ile239.B, Val243.B, Trp246.B
α1β2γ2, plus GABA  and diazepam, desensitized conformation, human, 6x3x
6x3x_EC F -15.6 Trp288.D, Val292.D, Phe296.D, Leu332.D, Phe336.D, Val339.D, Tyr340.D, Thr343.D, Tyr344.D, Arg347.D
G -14.4 Trp288.B, Val292.B, Phe296.B, Ser299.B, Leu332.B, Phe336.B, Val339.B, Thr343.B, Tyr344.B, Arg347.B
H -14.5 Leu298.E, Ala342.E, Leu345.E, Phe346.E, Val349.E, Tyr350.E, Ser353.E, Tyr354.E
M -13.5 Met283.A, Val327.A, Phe330.A, Phe331.A, Val334.A, Tyr335.A, Tyr338.A, Tyr339.A
N -13.5 Met233.E, Thr237.E, Tyr241.E, Ile242.E, Thr245.E, Cys344.E, Asn347.E, Trp351.E
O -13.0 Ile235.B, Ile239.B, Gln242.B, Pro330.B, Phe333.B, Gly334.B, Asn337.B, Trp341.B, Leu345.B
P -12.8 Ile218.A, Ile222.A, Met227.A, Ile230.A, Trp237.A, Pro325.A, Ser329.A, Asn332.A, Trp336.A, Val340.A
Q -12.6 Gly219.A, Ile222.A, Leu223.A, Met227.A, Val293.E, Leu298.E, Val302.E, Ile305.E
R -12.9 Val278.A, Met283.A, Val290.A, Phe291.A, Met294.A, Phe324.A, Val327.A, Phe331.A
S -12.8 Ala283.D, Trp288.D, Ala291.D, Ala295.D, Phe298.D, Ser299.D, Ile302.D, Ile238.E, Ile242.E, Leu246.E
T -13.5 Met283.C, Val327.C, Phe330.C, Phe331.C, Val334.C, Tyr335.C, Tyr338.C, Tyr339.C
U -13.4 Ile223.D, Val227.D, Ile235.D, Pro330.D, Leu331.D, Gly334.D, Asn337.D, Trp341.D, Leu345.D
V -13.4 Ile234.C, Trp237.C, Pro325.C, Phe328.C, Ser329.C, Asn332.C, Ile333.C, Trp336.C, Val340.C
W -13.1 Val227.B, Leu232.B, Ile235.B, Pro330.B, Leu331.B, Gly334.B, Asn337.B, Trp341.B
X -12.8 Ala283.B, Trp288.B, Ala291.B, Phe298.B, Ile222.C, Leu223.C, Met227.C, Leu231.C, Ile234.C
6x3x_IC F -15.6 Val302.E, Ile305.E, Phe306.E, Ser309.E, Glu313.E, Met331.E, Tyr334.E, Ala335.E, Phe338.E, Phe339.E, Ala342.E
G -12.9 Val292.B, Phe296.B, Ser299.B, Glu303.B, Thr306.B, Ile321.B, Ser325.B, Phe329.B, Leu332.B
H -15.0 Ala295.D, Ser299.D, Ile302.D, Glu303.D, Ile321.D, Leu324.D, Ser325.D, Ala328.D, Phe329.D, Leu332.D
M -15.0 Phe298.D, Ile302.D, Ala305.D, Thr306.D, Tyr309.D, Val249.E, Trp252.E, Val253.E, Trp256.E
N -12.8 Ile230.A, Leu231.A, Ile234.A, Trp237.A, Trp241.A, Arg321.A, Ile322.A, Pro325.A
O -12.6 Leu231.A, Ile305.E, Phe308.E, Ser309.E, Val312.E, Glu313.E, Thr316.E, Phe320.E
P -13.0 Leu297.A, Ala300.A, Leu301.A, Tyr304.A, Ile235.B, Ile239.B, Val243.B, Trp246.B
Q -12.8 Phe298.B, Ile302.B, Ala305.B, Thr306.B, Tyr309.B, Ile234.C, Trp237.C, Trp241.C, Pro325.C, Phe328.C, Ser329.C
α1β2γ2, plus GABA, desensitized conformation, human, 6x3z
6x3z_EC F -15.1 Val292.B, Leu332.B, Phe336.B, Val339.B, Tyr340.B, Thr343.B, Tyr344.B, Arg347.B
G -14.5 Trp288.D, Val292.D, Leu332.D, Ile335.D, Phe336.D, Val339.D, Tyr340.D, Thr343.D, Tyr344.D
H -13.7 Ser270.D, Arg274.D, Asp287.D, Ile290.D, Ala291.D, Tyr294.D, Ala295.D, Phe298.D, Ile238.E, Ile242.E, Pro243.E, Leu246.E
M -13.2 Leu298.E, Phe338.E, Ala342.E, Leu345.E, Phe346.E, Val349.E, Tyr350.E, Tyr354.E
N -13.2 Met233.E, Thr237.E, Tyr241.E, Ile242.E, Thr245.E, Phe343.E, Cys344.E, Trp351.E
O -13.1 Ile218.A, Ile222.A, Ile230.A, Trp237.A, Pro325.A, Ser329.A, Asn332.A, Trp336.A, Val340.A
P -12.7 Ile223.B, Val227.B, Leu232.B, Ile235.B, Ile239.B, Pro330.B, Phe333.B, Gly334.B, Asn337.B, Trp341.B
R -12.8 Met286.A, Phe293.A, Leu297.A, Gly224.B, Val227.B, Leu232.B, Met236.B, Ile239.B
S -13.4 Val278.A, Met283.A, Met286.A, Gly287.A, Val290.A, Phe291.A, Met294.A, Val327.A, Phe331.A
T -14.2 Met283.C, Val327.C, Phe330.C, Phe331.C, Val334.C, Tyr335.C, Tyr338.C, Tyr339.C
U -14.2 Trp288.B, Ala291.B, Ala295.B, Ser299.B, Gly219.C, Ile222.C, Leu223.C, Met227.C
V -13.4 Ile223.D, Val227.D, Ile235.D, Pro330.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D
W -13.3 Ile218.C, Ile222.C, Met227.C, Ile230.C, Ile234.C, Trp237.C, Pro325.C, Asn332.C, Trp336.C
6x3z_IC F -15.0 Ala295.B, Ser299.B, Ile302.B, Glu303.B, Ile321.B, Leu324.B, Ser325.B, Ala328.B, Phe329.B, Leu332.B
G -13.6 Val302.E, Phe306.E, Ser309.E, Glu313.E, Thr316.E, Met331.E, Phe338.E, Phe346.E
H -12.6 Phe293.A, Met294.A, Leu297.A, Glu298.A, Leu301.A, Ile316.A, Trp319.A, Met236.B
P -14.4 Phe298.B, Ile302.B, Ala305.B, Thr306.B, Tyr309.B, Ile234.C, Trp237.C, Val238.C, Trp241.C
Q -12.9 Trp237.C, Trp241.C, Arg321.C, Ile322.C, Pro325.C, Val326.C, Ser329.C, Ile333.C
α1β2γ2, plus GABA and picrotoxin, intermediate/resting state, human, 6x40
6x40_EC F -15.3 Ala285.B, Trp288.B, Val292.B, Leu332.B, Ile335.B, Phe336.B, Val339.B, Tyr340.B, Tyr344.B
G -15.2 Trp288.D, Val292.D, Leu332.D, Ile335.D, Phe336.D, Val339.D, Tyr340.D, Thr343.D, Tyr344.D, Arg347.D
H -14.4 Met233.E, Thr237.E, Tyr241.E, Ile242.E, Thr245.E, Trp252.E, Pro340.E, Cys344.E, Asn347.E, Trp351.E
M -13.4 Ile218.C, Ile222.C, Ile230.C, Trp237.C, Pro325.C, Ser329.C, Asn332.C, Trp336.C
N -13.2 Ile235.D, Ile239.D, Pro330.D, Phe333.D, Gly334.D, Asn337.D, Leu338.D, Trp341.D, Leu345.D
O -13.0 Ile223.B, Ile235.B, Pro330.B, Leu331.B, Gly334.B, Asn337.B, Leu338.B, Trp341.B, Leu345.B
P -12.7 Ala283.B, Trp288.B, Ala291.B, Val292.B, Ala295.B, Ser299.B, Ile302.B, Gly219.C, Leu223.C, Met227.C, Leu231.C
Q -12.6 Trp288.D, Ala291.D, Ala295.D, Phe298.D, Ser299.D, Ile302.D, Thr237.E, Ile238.E, Ile242.E, Leu246.E
R -13.1 Leu298.E, Val302.E, Ile305.E, Phe306.E, Ser309.E, Phe346.E, Val349.E, Tyr350.E, Ser353.E, Tyr354.E
S -13.0 Ile218.A, Ile222.A, Ile230.A, Trp237.A, Pro325.A, Ser329.A, Asn332.A, Trp336.A
T -12.7 Val278.A, Met283.A, Met286.A, Gly287.A, Val290.A, Phe291.A, Met294.A, Val327.A, Phe331.A, Ile228.B
6x40_IC F -14.0 Val292.B, Ala295.B, Ser299.B, Ile302.B, Glu303.B, Ile321.B, Asp322.B, Leu324.B, Ser325.B, Ala328.B, Phe329.B, Leu332.B
G -13.6 Phe298.B, Ile302.B, Ala305.B, Thr306.B, Tyr309.B, Ile230.C, Ile234.C, Trp237.C, Trp241.C, Pro325.C, Phe328.C, Ser329.C, Asn332.C
H -13.3 Val292.D, Ser299.D, Glu303.D, Lys320.D, Ile321.D, Leu324.D, Ser325.D, Ala328.D, Phe329.D, Leu332.D
M -13.7 Val302.E, Ile305.E, Phe306.E, Ser309.E, Glu313.E, Thr316.E, Met331.E, Phe338.E, Phe339.E, Phe346.E
N -12.8 Ile230.A, Ile234.A, Trp237.A, Trp241.A, Arg321.A, Ile322.A, Pro325.A, Ser329.A, Asn332.A
O -12.6 Met294.A, Glu298.A, Leu301.A, Ile316.A, Trp319.A, Phe324.A, Val327.A, Phe331.A
P -13.4 Phe298.D, Ile302.D, Ala305.D, Thr306.D, Tyr309.D, Val249.E, Val253.E, Trp256.E