Interfacial Cholesterol Binding Sites on TRPs

Transient Receptor Potential Channels [TRPA1- TRPN]

[Chl gives the letter assigned to cholesterol molecules in the PDB files; Units of E, kcals/mol with molar concentration units]

PDB Chl E Local Residues
TRPA1
TRPA1, Human, 3j9p
3j9p_EC E -13.3 Thr874.A, Phe877.A, Ile878.A, Leu902.A, Ile906.A, Phe909.A, Val935.D, Phe938.D, Ala939.D, Val942.D, Ile946.D
F -13.2 Val935.A, Phe938.A, Ala939.A, Val942.A, Ile946.A, Thr874.B, Phe877.B, Ile878.B, Leu902.B, Ile906.B, Phe909.B
G -12.5 Val935.A, Leu936.A, Val806.B, Leu807.B, Ile810.B, Leu830.B, Cys834.B, Ile837.B, Phe841.B
H -12.9 Phe879.A, Leu882.A, Ser900.A, Pro901.A, Leu902.A, Ile731.B, Val738.B, Trp843.B
I -12.5 Phe879.B, Leu882.B, Pro901.B, Leu902.B, Leu730.C, Ile731.C, Thr734.C, Val738.C, Trp843.C
J -13.3 Val935.B, Phe938.B, Ala939.B, Val942.B, Ile946.B, Thr874.C, Phe877.C, Ile878.C, Leu902.C, Ile906.C, Phe909.C
K -13.3 Val935.C, Phe938.C, Ala939.C, Val942.C, Ile946.C, Thr874.D, Phe877.D, Ile878.D, Leu902.D, Ile906.D, Phe909.D
L -12.9 Ile731.A, Val738.A, Trp843.A, Phe879.D, Leu882.D, Ser900.D, Pro901.D, Leu902.D, Ile905.D
M -12.4 Val935.B, Leu936.B, Val806.C, Leu807.C, Ile810.C, Leu830.C, Cys834.C, Ile837.C, Phe841.C
N -12.4 Val935.C, Leu936.C, Val806.D, Leu807.D, Ile810.D, Cys834.D, Ile837.D, Phe841.D
O -12.5 Phe879.C, Leu882.C, Pro901.C, Leu902.C, Leu730.D, Ile731.D, Thr734.D, Val738.D, Trp843.D
3j9p_IC E -13.0 Val935.B, Ala939.B, Leu871.C, Arg872.C, Thr874.C, Val875.C, Ile878.C, Leu902.C
F -12.9 Phe879.C, Leu882.C, Leu886.C, Pro901.C, Met720.D, Leu723.D, Cys727.D, Leu730.D, Ile731.D, Thr734.D, Val738.D, Trp843.D, Phe846.D
G -12.9 Met720.A, Leu723.A, Cys727.A, Leu730.A, Ile731.A, Thr734.A, Val738.A, Trp843.A, Phe846.A, Phe879.D, Leu882.D, Leu886.D, Pro901.D
H -12.9 Val935.C, Ala939.C, Val942.C, Leu871.D, Arg872.D, Thr874.D, Val875.D, Ile878.D, Leu902.D, Ile906.D
I -13.2 Val935.B, Leu936.B, Ala939.B, Phe947.B, Ile803.C, Val806.C, Leu807.C, Phe841.C
J -13.1 Val935.C, Leu936.C, Ala939.C, Phe947.C, Ile803.D, Val806.D, Leu807.D, Phe841.D
K -13.0 Phe879.B, Leu882.B, Leu886.B, Pro901.B, Met720.C, Leu723.C, Cys727.C, Leu730.C, Ile731.C, Thr734.C, Val738.C, Trp843.C, Phe846.C
L -13.0 Leu871.A, Arg872.A, Thr874.A, Val875.A, Ile878.A, Leu902.A, Val935.D, Ala939.D
M -13.0 Val935.A, Ala939.A, Leu871.B, Arg872.B, Thr874.B, Val875.B, Ile878.B, Leu902.B
N -13.0 Phe879.A, Leu882.A, Leu886.A, Pro901.A, Met720.B, Leu723.B, Cys727.B, Leu730.B, Ile731.B, Thr734.B, Val738.B, Trp843.B, Phe846.B
O -12.9 Phe938.A, Ala939.A, Val942.A, Ser943.A, Phe947.A, Ile803.B, Leu871.B, Ile906.B
P -13.1 Ile803.A, Ser804.A, Val806.A, Leu807.A, Phe841.A, Val935.D, Leu936.D, Ala939.D
TRPC3
TRPC3, closed, with PE and DAG, Human 6cud
6cud_EC E -12.3 Phe462.A, Ser466.A, Ala470.A, Thr473.A, Ala474.A, Leu477.A, Ser520.A, Pro522.A, Ile525.A
F -12.3 Met437.D, Phe462.D, Ser466.D, Ala470.D, Thr473.D, Ala474.D, Leu477.D, Pro522.D, Ile525.D
G -12.3 Leu348.C, Pro349.C, Ile383.C, Leu387.C, Phe390.C, Thr423.C, Trp424.C, Thr425.C, Leu428.C, Trp432.C
H -12.4 Leu348.D, Pro349.D, Ile383.D, Leu387.D, Phe390.D, Asp394.D, Thr423.D, Trp424.D, Thr425.D, Leu428.D, Trp432.D
I -12.4 Leu348.B, Pro349.B, Ile383.B, Leu387.B, Phe390.B, Thr423.B, Trp424.B, Thr425.B, Leu428.B, Trp432.B
J -12.4 Phe462.C, Ser466.C, Ala470.C, Thr473.C, Ala474.C, Leu477.C, Pro522.C, Ile525.C
K -12.4 Phe462.B, Ser466.B, Ala470.B, Thr473.B, Ala474.B, Leu477.B, Ser520.B, Pro522.B, Ile525.B
6cud_IC E -15.3 Leu348.B, Lys373.B, Ala376.B, His377.B, Ser380.B, Leu428.B, Val431.B, Trp432.B
F -15.3 Leu348.D, Lys373.D, Ala376.D, His377.D, Ser380.D, Leu428.D, Val431.D, Trp432.D
G -15.3 Leu348.C, Lys373.C, Ala376.C, His377.C, Ser380.C, Leu428.C, Val431.C, Trp432.C
H -13.7 Leu444.B, Pro449.B, Tyr452.B, Ile453.B, Val459.B, Phe462.B, Gly463.B, Ser466.B
I -13.7 Phe579.A, Val637.A, Leu638.A, Ile641.A, Trp457.B, Ile532.B, Val535.B, Leu536.B, Ser539.B, Ala542.B, Gln555.B, Leu558.B, Val562.B
J -13.7 Leu444.C, Pro449.C, Tyr452.C, Ile453.C, Val459.C, Phe462.C, Gly463.C, Ser466.C
K -13.6 Phe579.C, Val637.C, Leu638.C, Ile641.C, Trp457.D, Ile532.D, Val535.D, Leu536.D, Ser539.D, Ala542.D, Gln555.D, Leu558.D, Val562.D
L -15.3 Leu348.A, Lys373.A, Ala376.A, His377.A, Ser380.A, Leu428.A, Val431.A, Trp432.A
M -13.7 Leu444.D, Pro449.D, Tyr452.D, Ile453.D, Val459.D, Phe462.D, Gly463.D, Ser466.D, Leu529.D
N -13.6 Leu444.A, Pro449.A, Tyr452.A, Ile453.A, Val459.A, Phe462.A, Gly463.A, Ser466.A
O -13.6 Trp457.A, Ile532.A, Val535.A, Leu536.A, Ser539.A, Ala542.A, Gln555.A, Leu558.A, Val562.A, Phe579.D, Val637.D, Leu638.D, Ile641.D
TRPC4
TRPC4, closed, with CHS and PA, Mouse 5z96
5z96_EC E -13.6 Phe439.C, Val440.C, Ser443.C, Leu444.C, Ala447.C, Leu451.C, Trp471.C, Val476.C, Leu480.C
F -13.1 Phe439.D, Val440.D, Ser443.D, Leu444.D, Ala447.D, Leu451.D, Trp471.D, Val476.D, Leu480.D
G -12.4 Phe340.D, Pro341.D, Ile401.D, Trp404.D, Met405.D, Pro408.D, Trp409.D, Pro656.D, Phe657.D
H -12.6 Phe439.A, Ser443.A, Leu446.A, Ala447.A, Leu451.A, Trp471.A, Val476.A, Leu480.A
I -12.5 Phe340.C, Pro341.C, Ile401.C, Trp404.C, Met405.C, Pro408.C, Trp409.C, Pro656.C, Phe657.C
J -12.6 Phe439.B, Ser443.B, Leu446.B, Ala447.B, Leu451.B, Trp471.B, Pro473.B, Val476.B, Leu480.B
K -12.3 Phe340.B, Pro341.B, Ile401.B, Trp404.B, Met405.B, Pro408.B, Trp409.B, Pro656.B, Phe657.B
5z96_IC E -14.2 Leu374.A, Phe378.A, Leu492.A, Leu495.A, Phe496.A, Asn499.A, Leu502.A, Phe521.D, Leu525.D, Leu528.D
F -14.1 Phe521.C, Leu525.C, Leu528.C, Leu374.D, Phe378.D, Leu492.D, Leu495.D, Phe496.D, Asn499.D
G -14.2 Trp433.A, Trp434.A, Met437.A, Phe487.A, Leu513.A, Thr599.D, Thr603.D, Ile607.D
H -13.3 Val596.C, Thr599.C, Met600.C, Trp433.D, Leu436.D, Ile483.D, Phe487.D, Leu517.D
I -12.8 Val596.B, Thr599.B, Met600.B, Trp433.C, Leu436.C, Ile483.C, Phe487.C, Leu517.C
J -14.5 Phe521.A, Leu525.A, Leu528.A, Phe366.B, Leu374.B, Phe378.B, Leu492.B, Leu495.B, Phe496.B, Asn499.B
K -14.3 Phe521.B, Leu525.B, Leu528.B, Leu374.C, Phe378.C, Leu492.C, Leu495.C, Phe496.C, Asn499.C
TRPC4, closed, with CHS and PA, Zebrafish, 6glk
6glk_EC [none]
6g1k_IC E -14.3 Leu525.C, Leu528.C, Thr370.D, Leu374.D, Phe378.D, Leu492.D, Leu495.D, Phe496.D, Ala498.D, Asn499.D
F -14.2 Leu525.A, Leu528.A, Thr370.C, Leu374.C, Phe378.C, Leu381.C, Leu492.C, Leu495.C, Phe496.C, Ala498.C, Asn499.C
G -15.1 Phe521.C, Cys524.C, Leu525.C, Leu528.C, Leu568.C, Phe496.D, Asn499.D, Leu502.D
H -15.0 Phe521.A, Cys524.A, Leu525.A, Leu528.A, Leu568.A, Phe496.C, Asn499.C, Leu502.C
I -14.5 Leu330.D, Cys333.D, Val334.D, Gly337.D, Leu338.D, Ile367.D, Thr370.D, Ala371.D, Leu374.D, Phe378.D
J -14.4 Leu330.C, Cys333.C, Val334.C, Gly337.C, Leu338.C, Ile367.C, Thr370.C, Ala371.C, Leu374.C, Phe378.C
K -14.2 Thr370.A, Leu374.A, Phe378.A, Leu381.A, Leu492.A, Leu495.A, Phe496.A, Ala498.A, Asn499.A, Leu525.B, Leu528.B
L -12.3 Trp433.A, Ile483.A, Ile486.A, Phe487.A, Leu514.A, Leu517.A, Phe530.B, Thr599.B, Met600.B, Thr603.B
M -12.0 Trp433.B, Leu513.B, Leu514.B, Leu517.B, Phe572.B, Thr599.D, Gly602.D, Thr603.D
N -14.3 Phe366.B, Thr370.B, Leu374.B, Phe378.B, Leu492.B, Leu495.B, Phe496.B, Ala498.B, Leu525.D, Leu528.D
O -15.2 Phe496.A, Asn499.A, Leu502.A, Phe521.B, Cys524.B, Leu525.B, Leu528.B, Leu568.B
P -15.1 Phe496.B, Asn499.B, Leu502.B, Phe521.D, Cys524.D, Leu525.D, Leu528.D, Leu568.D
Q -14.4 Leu330.A, Cys333.A, Val334.A, Gly337.A, Leu338.A, Ile367.A, Thr370.A, Ala371.A, Leu374.A, Phe378.A
R -14.4 Leu330.B, Cys333.B, Val334.B, Gly337.B, Leu338.B, Ile367.B, Thr370.B, Ala371.B, Leu374.B, Phe378.B
S -12.3 Phe530.C, Thr599.C, Met600.C, Thr603.C, Trp433.D, Ile483.D, Ile486.D, Phe487.D, Leu514.D, Leu517.D
TRPC5
TRPC5, closed, with CHS, Mouse 6aei
6aei_EC E -12.4 Phe341.B, Pro342.B, Val402.B, Trp405.B, Met406.B, Trp410.B, Pro659.B, Pro660.B, Phe661.B
F -12.3 Leu437.C, Phe440.C, Ala441.C, Ser444.C, Leu445.C, Ala448.C, Leu452.C, Trp472.C, Pro474.C, Ile477.C, Leu481.C
G -12.1 Leu349.D, Val402.D, Trp405.D, Met406.D, Pro409.D, Pro660.D, Phe661.D, Ile663.D
H -12.0 Phe440.B, Ala441.B, Ser444.B, Leu445.B, Ala448.B, Leu452.B, Pro474.B, Ile477.B, Leu481.B
I -11.9 Phe440.B, Ser444.B, Leu447.B, Ala448.B, Leu452.B, Trp472.B, Pro474.B, Ile477.B
J -12.0 Ala441.A, Ser444.A, Leu445.A, Ala448.A, Leu452.A, Val455.A, Pro474.A, Ile477.A, Leu481.A
K -12.6 Phe341.A, Val402.A, Trp405.A, Met406.A, Pro409.A, Trp410.A, Pro659.A, Pro660.A
L -12.1 Phe440.D, Ala441.D, Ser444.D, Ala448.D, Leu452.D, Trp472.D, Ile477.D, Leu481.D
6aei_IC E -16.9 Phe531.A, Thr607.A, Ile611.A, Trp434.B, Trp435.B, Met438.B, Ile484.B, Leu488.B, Leu491.B, Ile494.B, Gln507.B, Leu510.B, Gly511.B, Leu514.B
F -14.4 Thr603.B, Met604.B, Thr607.B, Ile611.B, Trp434.C, Trp435.C, Met438.C, Ile484.C, Leu488.C, Leu491.C, Ile494.C, Gln507.C, Gly511.C, Leu514.C
G -14.3 Phe522.C, Leu526.C, Leu529.C, Leu375.D, Leu493.D, Leu496.D, Phe497.D, Ala499.D, Asn500.D, Leu503.D
H -14.2 Phe522.B, Leu526.B, Leu529.B, Leu375.C, Leu493.C, Leu496.C, Phe497.C, Ala499.C, Asn500.C, Leu503.C
I -14.5 Trp434.A, Trp435.A, Met438.A, Ile484.A, Leu488.A, Leu491.A, Leu514.A, Thr603.D, Met604.D, Thr607.D, Ile611.D
J -14.5 Thr603.C, Met604.C, Thr607.C, Ile611.C, Trp434.D, Trp435.D, Met438.D, Ile484.D, Leu488.D, Leu491.D, Gly511.D, Leu514.D
K -13.5 Leu375.A, Leu493.A, Leu496.A, Phe497.A, Asn500.A, Leu503.A, Phe522.D, Leu526.D, Leu529.D
L -13.5 Phe522.A, Leu529.A, Phe367.B, Leu375.B, Leu496.B, Phe497.B, Ala499.B, Asn500.B
TRPC6
TRPC6, closed, Human 5yx9
5yx9_EC E -14.8 Gly684.A, Leu685.A, Gly684.B, Leu685.B, Glu687.B, Phe683.C, Gly684.C, Leu685.C, Ile682.D, Phe683.D, Gly684.D, Leu685.D
F -14.1 Glu672.B, Glu673.B, Phe675.B, Lys676.B, Glu701.C, Asn702.C, Tyr705.C, Val706.C
G -13.7 Glu672.A, Glu673.A, Phe675.A, Lys676.A, Lys698.B, Asn702.B, Tyr705.B, Val706.B
H -12.4 Gly532.A, Ile536.A, Ala539.A, Ile542.A, Ala543.A, Met546.A, Pro591.A, Ile594.A, Leu598.A
I -12.3 Ile536.B, Ala539.B, Ile542.B, Ala543.B, Met546.B, Pro591.B, Ile594.B, Leu598.B
J -14.1 Glu701.A, Asn702.A, Tyr705.A, Val706.A, Glu672.D, Glu673.D, Phe675.D, Lys676.D
K -14.0 Glu672.C, Glu673.C, Phe675.C, Lys676.C, Glu701.D, Asn702.D, Tyr705.D, Val706.D
L -12.4 Phe531.D, Gly532.D, Ala535.D, Ile536.D, Ala539.D, Ile542.D, Ala543.D, Met546.D, Pro591.D, Ile594.D, Leu598.D
M -12.4 Phe531.C, Gly532.C, Ala535.C, Ile536.C, Ala539.C, Ile542.C, Ala543.C, Pro591.C, Ile594.C, Leu598.C
5yx9_IC E -14.8 Ile642.A, Met643.A, Val646.A, Met649.A, Thr451.D, Ile610.D, Ile613.D, Leu614.D
F -14.7 Phe443.A, Thr451.A, Ile610.A, Ile613.A, Leu614.A, Ile642.B, Met643.B, Val646.B, Met649.B
G -13.0 Trp526.A, Leu529.A, Ile601.A, Leu605.A, Leu627.A, Gly628.A, Val631.A, Phe648.B, Val706.B, Leu707.B, Val710.B, Thr714.B, Val718.B
H -12.9 Trp526.B, Leu529.B, Ile601.B, Leu605.B, Leu627.B, Gly628.B, Val631.B, Phe648.C, Val706.C, Leu707.C, Val710.C, Thr714.C, Val718.C
I -13.6 Leu525.A, Val631.A, Lys632.A, Phe635.A, Met638.A, Phe675.A, Phe679.A, Val706.B, Val710.B, Val713.B
J -13.5 Leu525.B, Val631.B, Lys632.B, Phe635.B, Met638.B, Phe675.B, Phe679.B, Val706.C, Val710.C, Val713.C
K -13.5 Val631.C, Lys632.C, Phe635.C, Met638.C, Phe675.C, Phe679.C, Val706.D, Val710.D, Val713.D
L -14.9 Thr451.C, Ile610.C, Ile613.C, Leu614.C, Ile642.D, Met643.D, Val646.D, Met649.D
M -14.7 Thr451.B, Ile610.B, Ile613.B, Leu614.B, Ile642.C, Met643.C, Val646.C, Met649.C
N -13.1 Phe648.A, Val706.A, Leu707.A, Val710.A, Thr714.A, Val718.A, Trp526.D, Leu529.D, Ile601.D, Leu605.D, Leu627.D, Gly628.D, Thr630.D, Val631.D
O -13.5 Val706.A, Val710.A, Val713.A, Val631.D, Lys632.D, Phe635.D, Met638.D, Phe675.D, Phe679.D
P -13.0 Trp526.C, Leu529.C, Ile601.C, Leu605.C, Leu627.C, Gly628.C, Thr630.C, Val631.C, Phe648.D, Val706.D, Leu707.D, Val710.D, Thr714.D, Val718.D
TRPM2
TRPM2, closed, plus CHS, Sea Anemone 6co7
6co7_EC E -15.5 Ile989.A, Leu992.A, Trp1020.A, Thr1024.A, Val1027.A, Gln1028.A, Tyr1031.A, Met1034.A, Trp1060.B, Leu1064.B, Ala1067.B, Val1071.B, Ile1075.B
F -15.5 Trp1060.A, Leu1064.A, Ala1067.A, Val1071.A, Ile989.D, Leu992.D, Trp1020.D, Thr1024.D, Val1027.D, Gln1028.D, Tyr1031.D, Met1034.D
G -13.0 Val846.C, Leu849.C, Ala850.C, Phe853.C, Leu854.C, Tyr857.C, His876.C, Thr878.C
H -12.9 Val846.D, Leu849.D, Ala850.D, Phe853.D, Leu854.D, Tyr857.D, Asn862.D, His876.D, Thr878.D
J -12.4 Phe923.D, Thr926.D, Val927.D, Ile930.D, Leu934.D, Ala945.D, Ile948.D, Ile949.D
K -12.4 Ile922.A, Phe923.A, Thr926.A, Val927.A, Ile930.A, Leu934.A, Ala945.A, Ile949.A
L -12.3 Leu872.D, Ile875.D, Ile880.D, Tyr883.D, Phe884.D, Phe887.D, Ile891.D, Phe936.D, Leu1123.D, Ile1127.D
M -12.3 Leu872.C, Ile875.C, Ile880.C, Tyr883.C, Phe884.C, Phe887.C, Ile891.C, Phe936.C, Leu1123.C, Ile1127.C
N -11.9 Trp1060.A, Leu1061.A, Phe923.D, Thr944.D, Ala945.D, Ile948.D, Ile949.D, Leu952.D, Phe956.D
O -12.6 Tyr723.D, Val846.D, Gly847.D, Ala850.D, Pro877.D, Val881.D, Pro1119.D, Pro1120.D
P -12.5 Tyr723.C, Val846.C, Gly847.C, Ala850.C, Pro877.C, Val881.C, Pro1119.C, Pro1120.C
Q -12.8 Leu872.C, Pro877.C, Ile880.C, Val881.C, Phe884.C, Leu1123.C, Leu1124.C, Ile1127.C
R -12.8 Leu872.D, Pro877.D, Ile880.D, Val881.D, Phe884.D, Leu1123.D, Leu1124.D, Ile1127.D
S -15.5 Ile989.B, Leu992.B, Trp1020.B, Thr1024.B, Val1027.B, Gln1028.B, Tyr1031.B, Met1034.B, Trp1060.C, Leu1064.C, Ala1067.C, Val1071.C, Ile1075.C
T -15.5 Ile989.C, Leu992.C, Trp1020.C, Thr1024.C, Val1027.C, Gln1028.C, Tyr1031.C, Met1034.C, Trp1060.D, Leu1064.D, Ala1067.D, Val1071.D, Ile1075.D
U -13.0 Val846.A, Leu849.A, Ala850.A, Phe853.A, Leu854.A, Tyr857.A, His876.A, Thr878.A
V -13.0 Val846.B, Leu849.B, Ala850.B, Phe853.B, Leu854.B, Tyr857.B, His876.B, Thr878.B
W -12.5 Tyr723.A, Val846.A, Gly847.A, Ala850.A, Pro877.A, Val881.A, Pro1119.A, Pro1120.A
X -12.4 Phe923.B, Thr926.B, Val927.B, Ile930.B, Leu934.B, Ala945.B, Ile948.B, Ile949.B
Y -12.4 Ile922.C, Phe923.C, Thr926.C, Val927.C, Ile930.C, Leu934.C, Ala945.C, Ile949.C
Z -12.4 Leu872.A, Ile875.A, Ile880.A, Tyr883.A, Phe884.A, Phe887.A, Ile891.A, Phe936.A, Leu1123.A, Ile1127.A
a -12.3 Leu872.B, Ile875.B, Ile880.B, Tyr883.B, Phe884.B, Phe887.B, Ile891.B, Phe936.B, Leu1123.B, Ile1127.B
b -12.1 Phe923.C, Ala945.C, Ile948.C, Ile949.C, Leu952.C, Phe956.C, Trp1060.D, Leu1061.D
c -12.0 Phe923.B, Thr944.B, Ala945.B, Ile948.B, Ile949.B, Leu952.B, Phe956.B, Trp1060.C, Leu1061.C
d -12.8 Leu872.A, Pro877.A, Ile880.A, Val881.A, Phe884.A, Leu1123.A, Leu1124.A, Ile1127.A
6co7_IC E -16.5 Thr916.C, Trp917.C, Ile955.C, Val959.C, Ile978.C, Gln979.C, Met982.C, Phe995.D, Tyr999.D, Leu1065.D, Ile1068.D, Tyr1069.D
F -16.5 Phe995.A, Tyr999.A, Leu1065.A, Ile1068.A, Tyr1069.A, Thr916.D, Trp917.D, Ile955.D, Val959.D, Ile978.D, Gln979.D, Met982.D
G -16.5 Thr916.A, Trp917.A, Ile955.A, Phe956.A, Val959.A, Val976.A, Ile978.A, Gln979.A, Phe995.B, Tyr999.B, Leu1065.B, Ile1068.B, Tyr1069.B
H -14.2 Phe887.D, Ile891.D, Ile894.D, Arg895.D, His1126.D, Ile1129.D, Phe1130.D, Trp1133.D
I -14.2 Phe887.A, Ile891.A, Ile894.A, Arg895.A, His1126.A, Ile1129.A, Phe1130.A, Trp1133.A
J -13.8 Phe841.C, Val845.C, Leu849.C, Ile852.C, Phe853.C, Ile964.C, Phe965.C, Ile997.D, Ile1001.D
K -13.8 Ile997.A, Ile1001.A, Phe841.D, Val845.D, Leu849.D, Ile852.D, Phe853.D, Ile964.D, Phe965.D, Val967.D
L -16.7 Thr916.B, Trp917.B, Ile955.B, Phe956.B, Val959.B, Ile978.B, Gln979.B, Phe995.C, Tyr999.C, Leu1065.C, Ile1068.C, Tyr1069.C
M -14.2 Phe887.C, Ile891.C, Ile894.C, Arg895.C, His1126.C, Ile1129.C, Phe1130.C, Trp1133.C
N -14.2 Phe887.B, Ile891.B, Ile894.B, Arg895.B, His1126.B, Ile1129.B, Phe1130.B, Trp1133.B
O -13.8 Phe841.B, Val845.B, Leu849.B, Ile852.B, Phe853.B, Ile964.B, Phe965.B, Val967.B, Asn968.B, Ile997.C, Ile1001.C
P -13.7 Phe841.A, Val845.A, Leu849.A, Ile852.A, Phe853.A, Ile964.A, Phe965.A, Asn968.A, Ile997.B, Ile1001.B
TRPM2, open, Zebrafish 6drj
6drj_EC E -14.5 Trp815.B, Gly822.B, Trp825.B, Leu826.B, Val829.B, Arg842.B, Trp849.B, Pro1096.B, Pro1098.B, Phe1099.B
F -14.0 Trp815.C, Gly822.C, Trp825.C, Leu826.C, Val829.C, Arg842.C, Trp849.C, Pro1096.C, Pro1098.C, Phe1099.C
G -13.9 Trp815.D, Gly822.D, Trp825.D, Leu826.D, Val829.D, Arg842.D, Trp849.D, Pro1096.D, Pro1098.D, Phe1099.D
H -13.3 Glu1037.B, Trp1038.B, Ile1041.B, Met1042.B, Phe951.C, Met954.C, Phe955.C, Ser958.C, Val987.C, Tyr988.C, Tyr991.C
I -13.3 Glu1037.A, Trp1038.A, Ile1041.A, Met1042.A, Phe951.B, Met954.B, Phe955.B, Val987.B, Tyr988.B, Tyr991.B
J -12.9 Phe951.C, Phe955.C, Val962.C, Leu979.C, Ile982.C, Ile983.C, Trp825.D, Ala828.D, Val829.D, Ile833.D
K -12.9 Phe951.B, Phe955.B, Val962.B, Leu979.B, Ile982.B, Ile983.B, Val987.B, Trp825.C, Ala828.C, Met832.C, Ile833.C
L -12.7 Phe955.A, Val962.A, Leu979.A, Ile982.A, Ile983.A, Val987.A, Phe821.B, Trp825.B, Ala828.B, Met832.B, Ile833.B
M -12.6 Asn997.A, Thr1000.A, Asn997.B, Asn997.C, Thr1000.C, Ile1060.C, Asn997.D, Thr1000.D
N -13.8 Trp815.A, Trp825.A, Leu826.A, Val829.A, Arg842.A, Trp849.A, Pro1096.A, Pro1098.A, Phe1099.A
O -13.4 Glu1037.C, Trp1038.C, Ile1041.C, Met1042.C, Phe951.D, Met954.D, Phe955.D, Ser958.D, Val987.D, Tyr988.D, Tyr991.D
P -13.1 Phe951.A, Met954.A, Phe955.A, Ser958.A, Val987.A, Tyr988.A, Tyr991.A, Glu1037.D, Trp1038.D, Ile1041.D, Met1042.D
Q -12.9 Trp825.A, Ala828.A, Val829.A, Ile833.A, Phe951.D, Phe955.D, Val962.D, Leu979.D, Ile982.D, Ile983.D
6drj_IC [none]
TRPM2, closed, Zebrafish 6drk
6drk_EC E -13.8 Asn997.A, Thr1000.A, Asn997.B, Thr1000.B, Asn997.C, Thr1000.C, Asn997.D, Thr1000.D
F -13.7 Trp815.C, Ala818.C, Ser819.C, Leu826.C, Trp841.C, Arg842.C, Leu845.C, Pro1096.C, Pro1098.C
G -13.4 Phe951.A, Met954.A, Phe955.A, Ile983.A, Arg984.A, Val987.A, Tyr988.A, Trp1038.D, Ile1041.D, Met1042.D
H -13.1 Leu888.A, Leu892.A, Tyr909.A, Ile910.A, Val913.A, Ile914.A, Ile917.A, Ile921.A, Phe1035.D, Pro1036.D, Leu1039.D
I -12.7 Phe1035.A, Leu1039.A, Leu888.B, Leu892.B, Ile910.B, Val913.B, Ile914.B, Ile917.B, Ile921.B
J -12.6 Glu1037.A, Trp1038.A, Ile1041.A, Met1042.A, Phe951.B, Phe955.B, Val987.B, Tyr988.B
K -12.3 Ala818.B, Ser819.B, Gly822.B, Trp825.B, Leu826.B, Val829.B, Arg842.B, Trp849.B, Pro1098.B
L -13.8 Asn997.A, Thr1000.A, Asn997.B, Thr1000.B, Asn997.C, Thr1000.C, Asn997.D, Thr1000.D
M -13.7 Ile1041.C, Met1042.C, Phe951.D, Met954.D, Phe955.D, Ser958.D, Ile983.D, Arg984.D, Val987.D, Tyr988.D
M -13.0 Phe1035.C, Leu1039.C, Leu888.D, Leu892.D, Tyr909.D, Ile910.D, Val913.D, Ile914.D, Ile917.D, Ile921.D
O -12.8 Met1042.B, Leu1049.B, Phe951.C, Met954.C, Ile983.C, Arg984.C, Val987.C, Tyr988.C, Tyr991.C
P -12.6 Ser819.D, Leu826.D, Trp841.D, Arg842.D, Leu845.D, Pro1096.D, Pro1098.D, Phe1099.D
Q -12.6 Phe1035.B, Leu1039.B, Leu888.C, Tyr909.C, Ile910.C, Val913.C, Ile914.C, Ile917.C, Ile921.C
R -12.2 Ser819.A, Gly822.A, Trp825.A, Leu826.A, Val829.A, Arg842.A, Trp849.A, Pro1098.A, Leu979.D
6drk_IC E -16.0 Asn1052.A, Asn1057.A, Ile1060.A, Asn1064.A, Ile1060.B, Asn1064.B, Ile1060.C, Asn1064.C, Ile1060.D, Asn1064.D
F -15.0 Trp960.A, Val1046.A, Phe1050.A, Trp882.B, Leu924.B, Met927.B, Ile940.B, Val943.B, Arg944.B, Met947.B
G -14.0 Leu881.A, Leu885.A, Ile917.A, Leu924.A, Arg944.A, Met947.A, Met1042.D, Met1043.D, Val1046.D
H -14.0 Trp960.A, Tyr964.A, Met1043.A, Val1046.A, Tyr1047.A, Phe1050.A, Leu881.B, Trp882.B, Ile920.B, Leu924.B, Arg944.B
I -13.9 Trp960.A, Met1043.A, Val1046.A, Tyr1047.A, Phe1050.A, Leu881.B, Ile920.B, Leu924.B, Arg944.B, Met947.B, Leu948.B
J -13.5 Leu881.D, Trp882.D, Ile884.D, Leu885.D, Leu888.D, Ile917.D, Ile921.D, Leu924.D, Arg944.D
K -14.3 Arg944.A, Met947.A, Leu948.A, Phe951.A, Met954.A, Tyr991.A, Cys1045.D, Val1046.D, Leu1049.D
L -14.2 Thr851.B, Cys855.B, Ile858.B, Arg859.B, Tyr862.B, Ile894.B, Leu897.B, Ile898.B
M -15.0 Thr851.D, Cys855.D, Ile858.D, Arg859.D, Tyr862.D, Ile894.D, Leu897.D, Ile898.D
N -13.0 Trp960.B, Met1043.B, Leu881.C, Trp882.C, Leu885.C, Ile917.C, Ile920.C, Leu924.C, Arg944.C
O -13.1 Thr851.A, Val854.A, Cys855.A, Ile858.A, Arg859.A, Ile894.A, Leu897.A, Ile898.A
P -14.7 Trp960.C, Tyr964.C, Met1043.C, Val1046.C, Tyr1047.C, Phe1050.C, Ile920.D, Leu924.D, Arg944.D, Met947.D, Leu948.D
Q -14.5 Met1042.C, Cys1045.C, Val1046.C, Leu1049.C, Leu881.D, Arg944.D, Met947.D, Leu948.D, Phe951.D, Tyr991.D
R -13.6 Trp960.B, Val1046.B, Phe1050.B, Trp882.C, Leu924.C, Met927.C, Ile940.C, Val943.C, Arg944.C, Met947.C
S -13.2 Trp960.B, Met1043.B, Val1046.B, Tyr1047.B, Ile920.C, Arg944.C, Met947.C, Leu948.C
TRPM2, closed, Human 6mix
6mix_EC E -15.6 Arg962.B, Val963.B, Asp964.B, Trp965.B, Leu966.B, Phe967.B, Phe807.C, Leu810.C, Cys811.C, Ala814.C, Met818.C, Phe903.C
F -15.5 Val946.C, Val950.C, Arg962.C, Val963.C, Asp964.C, Trp965.C, Leu966.C, Phe967.C, Phe807.D, Cys811.D, Met818.D, Phe903.D
G -14.3 Phe979.A, Gly980.A, Gln981.A, Phe979.B, Gly980.B, Gln981.B, Phe979.C, Gly980.C, Gln981.C, Gly980.D, Gln981.D, Ile982.D
H -15.7 Phe807.A, Leu810.A, Cys811.A, Met818.A, Phe903.A, Val946.D, Val950.D, Arg962.D, Val963.D, Asp964.D, Trp965.D, Leu966.D, Phe967.D, Val971.D
I -15.7 Val946.A, Val950.A, Arg962.A, Val963.A, Asp964.A, Trp965.A, Leu966.A, Phe967.A, Phe807.B, Cys811.B, Met818.B, Phe903.B
6mix_IC F -14.1 Trp1023.B, Val1026.B, Leu1027.B, Lys932.C, Phe935.C, Leu938.C, Phe939.C, Phe967.C, Trp754.D
G -13.9 Trp1023.A, Val1026.A, Leu1027.A, Lys932.B, Phe935.B, Leu938.B, Phe939.B, Phe967.B, Trp754.C
H -14.1 Leu753.A, Trp754.A, Thr757.A, Trp1023.C, Val1026.C, Leu1027.C, Phe939.D, Phe967.D
I -13.3 Phe867.B, Lys870.B, Leu871.B, Gly874.B, Leu878.B, Ile898.B, Leu901.B, Leu905.B
J -13.3 Leu836.B, Val840.B, Cys841.B, Glu843.B, Met844.B, Leu847.B, Ile876.B, Val880.B, Leu883.B, Thr884.B, Leu887.B
K -13.3 Trp1023.B, Leu1024.B, Lys870.C, Gly874.C, Leu878.C, Val897.C, Ile898.C, Leu901.C, Leu905.C
L -13.2 Leu836.C, Val840.C, Cys841.C, Glu843.C, Met844.C, Ile876.C, Val880.C, Leu883.C, Thr884.C, Leu887.C
M -13.0 Leu836.D, Val840.D, Cys841.D, Glu843.D, Met844.D, Leu847.D, Ile876.D, Val880.D, Leu883.D, Thr884.D, Leu887.D
N -13.9 Lys932.A, Phe935.A, Leu938.A, Phe939.A, Phe967.A, Trp754.B, Trp1023.D, Val1026.D, Leu1027.D
P -13.2 Phe867.A, Lys870.A, Leu871.A, Gly874.A, Leu878.A, Ile898.A, Leu901.A, Leu905.A
Q -13.4 Trp1023.C, Leu1024.C, Lys870.D, Gly874.D, Leu878.D, Val897.D, Ile898.D, Leu901.D, Leu905.D
TRPM2, closed, Human 6miz
6miz_EC E -14.2 Phe1020.A, Trp1023.A, Leu938.B, Phe939.B, Ala942.B, Val943.B, Asp964.B, Phe967.B
F -13.6 Pro825.C, Tyr833.C, Leu834.C, Leu836.C, Phe837.C, Phe879.C, Leu883.C, Arg886.C, Leu887.C
G -13.6 Tyr833.D, Leu834.D, Leu836.D, Phe837.D, Phe879.D, Leu883.D, Arg886.D, Leu887.D
H -13.5 Tyr833.B, Leu834.B, Leu836.B, Phe837.B, Phe879.B, Leu883.B, Arg886.B, Leu887.B
I -13.3 Phe1020.B, Trp1023.B, Leu1024.B, Leu878.C, Pro894.C, Val897.C, Ile898.C, Leu901.C, Leu905.C
J -13.3 Phe1020.A, Trp1023.A, Leu1024.A, Leu878.B, Pro894.B, Val897.B, Ile898.B, Leu901.B, Leu905.B
K -14.3 Phe1020.B, Trp1023.B, Leu938.C, Phe939.C, Ala942.C, Val943.C, Asp964.C, Phe967.C
L -12.9 Val873.B, Leu877.B, Ala881.B, Thr884.B, Cys885.B, Thr891.B, Pro894.B, Ile898.B
M -12.6 Gly874.C, Leu877.C, Leu878.C, Ala881.C, Cys885.C, Thr891.C, Pro894.C, Ile898.C
N -12.5 Phe939.C, Leu966.C, Phe967.C, Ala970.C, Val971.C, Leu804.D, Phe807.D, Met818.D
O -12.7 Leu801.B, Leu804.B, Ser805.B, Ala808.B, Leu812.B, Tyr815.B, Trp827.B, Cys828.B, Ala831.B
P -14.1 Phe1020.C, Trp1023.C, Leu938.D, Phe939.D, Ala942.D, Val943.D, Asp964.D, Phe967.D
Q -14.0 Leu938.A, Phe939.A, Ala942.A, Val943.A, Asp964.A, Phe967.A, Phe1020.D, Trp1023.D
R -13.3 Phe1020.C, Trp1023.C, Leu1024.C, Leu878.D, Pro894.D, Val897.D, Ile898.D, Leu901.D, Leu905.D
S -13.3 Tyr833.A, Leu834.A, Leu836.A, Phe837.A, Val840.A, Phe879.A, Leu883.A, Arg886.A, Leu887.A
T -13.1 Leu878.A, Pro894.A, Val897.A, Ile898.A, Leu901.A, Leu905.A, Phe1020.D, Trp1023.D, Leu1024.D
U -13.0 Val873.A, Leu877.A, Ala881.A, Thr884.A, Cys885.A, Thr891.A, Pro894.A, Ile898.A
V -12.8 Leu801.A, Leu804.A, Ser805.A, Ala808.A, Leu812.A, Tyr815.A, Trp827.A, Cys828.A, Ala831.A
W -12.8 Val873.D, Leu877.D, Ala881.D, Thr884.D, Cys885.D, Thr891.D, Pro894.D, Ile898.D
6miz_IC E -14.6 Trp1023.A, Val1026.A, Leu1027.A, Phe935.B, Leu938.B, Phe939.B, Phe967.B, Leu753.C, Trp754.C, Thr757.C
F -14.6 Trp1023.B, Val1026.B, Leu1027.B, Lys932.C, Phe935.C, Leu938.C, Phe939.C, Phe967.C, Leu753.D, Trp754.D, Thr757.D
G -14.1 Phe979.A, Gly980.A, Leu1041.A, Asn1042.A, Ile1045.A, Leu1041.B, Asn1042.B, Ile1045.B, Phe979.C, Gly980.C, Leu1041.C, Asn1042.C, Ile1045.C, Phe979.D, Gly980.D, Leu1041.D, Asn1042.D, Ile1045.D
H -14.0 Leu1024.B, Leu1027.B, Leu1031.B, Phe1035.B, Leu871.C, Ile898.C, Leu901.C, Leu905.C, Leu908.C, Met931.C, Lys932.C, Val934.C, Phe935.C
I -14.0 Val840.D, Cys841.D, Glu843.D, Met844.D, Leu847.D, Ile876.D, Leu883.D, Thr884.D
J -14.0 Val840.C, Cys841.C, Glu843.C, Met844.C, Leu847.C, Ile876.C, Val880.C, Leu883.C, Thr884.C
K -14.0 Leu1024.C, Leu1027.C, Leu1031.C, Phe1035.C, Leu871.D, Ile898.D, Leu901.D, Leu905.D, Leu908.D, Met931.D, Val934.D, Phe935.D
L -13.7 Phe867.C, Lys870.C, Leu871.C, Gly874.C, Leu877.C, Leu878.C, Ala881.C, Cys885.C, Ile898.C
M -13.6 Phe867.D, Lys870.D, Leu871.D, Gly874.D, Leu877.D, Leu878.D, Ala881.D, Cys885.D, Ile898.D
N -14.0 Leu1024.A, Leu1027.A, Leu1031.A, Phe1035.A, Leu871.B, Ile898.B, Leu901.B, Leu905.B, Leu908.B, Met931.B, Val934.B, Phe935.B
O -13.9 Val840.B, Glu843.B, Met844.B, Leu847.B, Ile876.B, Val880.B, Leu883.B, Thr884.B
P -13.7 Phe867.B, Lys870.B, Leu871.B, Gly874.B, Leu877.B, Leu878.B, Ala881.B, Cys885.B, Ile898.B
Q -14.6 Lys932.A, Phe935.A, Leu938.A, Phe939.A, Phe967.A, Leu753.B, Trp754.B, Thr757.B, Trp1023.D, Val1026.D, Leu1027.D
R -14.4 Leu753.A, Trp754.A, Thr757.A, Trp1023.C, Val1026.C, Lys932.D, Phe935.D, Phe939.D, Phe967.D
S -13.9 Val840.A, Cys841.A, Glu843.A, Met844.A, Leu847.A, Ile876.A, Val880.A, Thr884.A
T -13.8 Leu871.A, Leu901.A, Leu905.A, Leu908.A, Val927.A, Met931.A, Val934.A, Phe935.A, Trp1023.D, Leu1024.D, Leu1027.D, Leu1031.D, Phe1035.D
TRPM2, closed, Ca and ADPR-bound, Human 6mj2
6mj2_EC E -12.7 Phe1020.A, Pro1021.A, Trp1023.A, Leu1024.A, Leu878.B, Thr891.B, Pro894.B, Ile898.B, Leu901.B, Leu905.B
F -12.7 Pro1021.C, Trp1023.C, Leu1024.C, Leu878.D, Thr891.D, Pro894.D, Ile898.D, Leu901.D, Leu905.D
G -12.7 Pro1021.B, Trp1023.B, Leu1024.B, Leu878.C, Thr891.C, Pro894.C, Ile898.C, Leu901.C, Leu905.C
H -12.3 Leu801.D, Ser805.D, Leu812.D, Tyr815.D, Cys828.D, Trp835.D, Pro1081.D, Pro1083.D
I -12.3 Leu761.C, Leu801.C, Leu804.C, Ser805.C, Ala808.C, Leu812.C, Tyr815.C, Cys828.C
J -12.2 Pro825.C, Tyr833.C, Phe837.C, Val840.C, Ile876.C, Val880.C, Leu883.C, Leu887.C
K -12.2 Pro825.D, Tyr833.D, Phe837.D, Val840.D, Ile876.D, Val880.D, Leu883.D, Leu887.D
L -12.7 Leu878.A, Thr891.A, Pro894.A, Ile898.A, Leu901.A, Leu905.A, Phe1020.D, Pro1021.D, Trp1023.D, Leu1024.D
M -12.3 Leu801.B, Ser805.B, Leu812.B, Tyr815.B, Cys828.B, Trp835.B, Pro1081.B, Pro1083.B
N -12.3 Leu801.A, Ser805.A, Leu812.A, Tyr815.A, Cys828.A, Trp835.A, Pro1081.A, Pro1083.A
O -12.2 Pro825.A, Tyr833.A, Phe837.A, Val840.A, Ile876.A, Val880.A, Leu883.A, Leu887.A
P -12.2 Pro825.B, Tyr833.B, Phe837.B, Val840.B, Ile876.B, Val880.B, Leu883.B, Leu887.B
6mj2_IC E -14.5 Val840.B, Glu843.B, Met844.B, Gln846.B, Leu847.B, Tyr863.B, Ile876.B, Val880.B
F -14.5 Val840.A, Glu843.A, Met844.A, Gln846.A, Leu847.A, Tyr863.A, Ile876.A, Val880.A
G -14.5 Val840.D, Glu843.D, Met844.D, Gln846.D, Leu847.D, Tyr863.D, Ile876.D, Val880.D
TRPM4
TRPM4, closed, with Ca and decavanadate, Human 5wp6
5wp6_EC E -14.9 Leu934.A, Leu963.A, Arg964.A, Phe967.A, Tyr968.A, Val1021.D, Leu1022.D, Val1025.D
F -14.9 Val1021.C, Leu1022.C, Val1025.C, Leu934.D, Leu963.D, Arg964.D, Phe967.D, Tyr968.D
G -13.8 Leu791.A, Leu795.A, Ser798.A, Leu802.A, Leu906.A, Phe935.D, Val939.D, Val942.D, Phe959.D, Ile962.D, Leu963.D, Phe967.D
H -13.8 Phe935.C, Val939.C, Val942.C, Phe959.C, Ile962.C, Leu963.C, Phe967.C, Leu791.D, Leu795.D, Ser798.D, Leu802.D, Leu906.D
I -13.7 Val788.A, Ser789.A, Leu792.A, Leu796.A, Ser812.A, Leu813.A, Leu816.A, Trp820.A, Ala1076.A, Pro1078.A, Phe1079.A
J -13.6 Val788.B, Ser789.B, Leu792.B, Leu796.B, Ser812.B, Leu813.B, Leu816.B, Trp820.B, Ala1076.B, Pro1078.B, Phe1079.B
K -12.6 Tyr1015.C, Ala1016.C, Trp1018.C, Leu1019.C, Val870.D, Cys874.D, Leu890.D, Thr893.D, Val894.D, Ile897.D, Val901.D
L -12.5 Val870.A, Cys874.A, Leu890.A, Thr893.A, Val894.A, Ile897.A, Val901.A, Ala1016.D, Trp1018.D, Leu1019.D
M -13.4 Phe935.A, Val939.A, Val942.A, Phe959.A, Ile962.A, Leu963.A, Phe967.A, Leu791.B, Leu795.B, Ser798.B, Leu802.B, Leu906.B
N -15.0 Val1021.A, Leu1022.A, Val1025.A, Phe931.B, Leu934.B, Leu963.B, Arg964.B, Phe967.B, Tyr968.B
O -14.9 Val1021.B, Leu1022.B, Val1025.B, Leu934.C, Leu963.C, Arg964.C, Phe967.C, Tyr968.C
P -13.8 Phe935.B, Val939.B, Val942.B, Phe959.B, Ile962.B, Leu963.B, Phe967.B, Leu791.C, Leu795.C, Ser798.C, Leu802.C, Leu906.C
Q -13.7 Val788.D, Ser789.D, Leu792.D, Leu796.D, Ser812.D, Leu813.D, Leu816.D, Trp820.D, Ala1076.D, Pro1078.D, Phe1079.D
R -13.6 Val788.C, Ser789.C, Leu792.C, Leu796.C, Ser812.C, Leu813.C, Leu816.C, Trp820.C, Ala1076.C, Pro1078.C, Phe1079.C
S -12.4 Ala1016.B, Trp1018.B, Leu1019.B, Val870.C, Cys874.C, Leu890.C, Thr893.C, Val894.C, Ile897.C, Val901.C
T -12.4 Ala1016.A, Trp1018.A, Leu1019.A, Val870.B, Cys874.B, Leu890.B, Thr893.B, Val894.B, Ile897.B, Val901.B
5wp6_IC E -15.9 Phe936.C, Trp940.C, Leu1023.C, Trp864.D, Ile897.D, Met900.D, Val901.D, Val904.D, Ile920.D, Val921.D, Val923.D, Ser924.D, Met927.D
F -15.9 Trp864.A, Ile897.A, Met900.A, Val901.A, Val904.A, Ile920.A, Val921.A, Val923.A, Ser924.A, Met927.A, Phe936.D, Trp940.D, Leu1023.D
G -14.9 Phe931.A, Leu934.A, Phe935.A, Gly938.A, Leu941.A, Phe967.A, Phe910.B, Asn913.B, Gln915.B, Leu916.B
H -14.9 Phe910.A, Asn913.A, Gln915.A, Leu916.A, Phe931.D, Leu934.D, Phe935.D, Gly938.D, Leu941.D, Phe967.D
I -13.5 Ile690.B, Val694.B, Phe783.B, Met784.B, Val787.B, Val788.B, Leu791.B, Leu792.B, Phe910.B, Asn913.B
J -13.4 Ile690.A, Val694.A, Phe783.A, Met784.A, Val787.A, Val788.A, Leu791.A, Leu792.A, Phe910.A, Asn913.A
K -13.1 Phe697.A, Trp776.A, Ile782.A, Gly785.A, Ala1074.A, Leu1075.A, Ala1076.A, Pro1078.A, Phe1079.A
L -13.0 Phe697.B, Trp776.B, Ile782.B, Gly785.B, Val788.B, Ala1074.B, Leu1075.B, Ala1076.B, Pro1078.B, Phe1079.B
M -12.9 Ser863.A, Cys867.A, Val870.A, Cys874.A, Ile897.A, Asp898.A, Val901.A, Ser924.A
N -12.9 Ser863.D, Cys867.D, Val870.D, Cys874.D, Ile897.D, Asp898.D, Val901.D, Ser924.D
O -15.9 Phe936.A, Trp940.A, Leu1023.A, Trp864.B, Ile897.B, Met900.B, Val901.B, Val904.B, Leu907.B, Ile920.B, Val921.B, Val923.B, Ser924.B, Met927.B
P -15.9 Phe936.B, Trp940.B, Leu1023.B, Trp864.C, Ile897.C, Met900.C, Val901.C, Val904.C, Leu907.C, Ile920.C, Val921.C, Val923.C, Ser924.C, Met927.C
Q -14.9 Phe931.B, Leu934.B, Phe935.B, Gly938.B, Leu941.B, Phe967.B, Phe910.C, Asn913.C, Gln915.C, Leu916.C
R -14.9 Phe931.C, Leu934.C, Phe935.C, Gly938.C, Leu941.C, Phe967.C, Phe910.D, Asn913.D, Gln915.D, Leu916.D
S -13.5 Ile690.C, Val694.C, Phe783.C, Met784.C, Val787.C, Val788.C, Leu791.C, Leu792.C, Phe910.C, Asn913.C
T -13.4 Trp680.D, Ile690.D, Val694.D, Phe783.D, Met784.D, Val787.D, Val788.D, Leu791.D, Leu792.D, Phe910.D, Asn913.D
U -13.1 Phe697.D, Trp776.D, Ile782.D, Gly785.D, Ala1074.D, Leu1075.D, Ala1076.D, Pro1078.D, Phe1079.D
V -13.0 Phe697.C, Trp776.C, Ile782.C, Gly785.C, Val788.C, Ala1074.C, Leu1075.C, Ala1076.C, Pro1078.C, Phe1079.C
W -12.9 Ser863.C, Cys867.C, Val870.C, Cys874.C, Ile897.C, Asp898.C, Val901.C, Ser924.C
X -13.0 Ser863.B, Cys867.B, Val870.B, Cys874.B, Ile897.B, Asp898.B, Val901.B, Ser924.B
TRPM4, closed, Mouse 6bcj
6bcj_EC E -16.1 Leu959.C, Arg960.C, Phe963.C, Tyr964.C, Trp1014.D, Val1017.D, Leu1018.D, Ile1021.D
F -16.0 Cys934.A, Pro956.A, Leu959.A, Arg960.A, Phe963.A, Tyr964.A, Val1017.C, Ile1021.C
G -13.6 Ser785.B, Leu788.B, Leu792.B, His795.B, Asp800.B, Ser809.B, Leu812.B, Trp816.B, Ala1072.B, Pro1074.B, Leu1075.B
H -13.6 Ser785.A, Leu788.A, Leu792.A, His795.A, Asp800.A, Ser809.A, Leu812.A, Trp816.A, Ala1072.A, Pro1074.A, Leu1075.A
I -12.3 Leu791.A, Ala794.A, His795.A, Leu798.A, Val799.A, Cys934.C, Val935.C, Val938.C, Val942.C, Leu955.C, Ile958.C, Leu959.C, Phe963.C
J -13.0 Cys934.A, Val935.A, Val938.A, Val942.A, Leu955.A, Ile958.A, Leu959.A, Phe963.A, Leu791.B, Ala794.B, His795.B, Leu798.B, Val799.B
K -13.7 Ser785.C, Leu788.C, Leu792.C, His795.C, Asp800.C, Ser809.C, Leu812.C, Trp816.C, Ala1072.C, Pro1074.C, Leu1075.C
L -12.3 Leu791.C, Ala794.C, His795.C, Leu798.C, Val799.C, Cys934.D, Val935.D, Val938.D, Val942.D, Leu955.D, Ile958.D, Leu959.D, Phe963.D
M -16.1 Val1017.B, Ile1021.B, Cys934.D, Pro956.D, Leu959.D, Arg960.D, Phe963.D, Tyr964.D
N -16.0 Val1017.A, Ile1021.A, Cys934.B, Pro956.B, Leu959.B, Arg960.B, Phe963.B, Tyr964.B
O -13.6 Ser785.D, Leu788.D, Leu792.D, His795.D, Asp800.D, Ser809.D, Leu812.D, Trp816.D, Ala1072.D, Pro1074.D, Leu1075.D
P -12.7 Cys934.B, Val935.B, Val938.B, Val942.B, Leu955.B, Ile958.B, Leu959.B, Phe963.B, Leu791.D, Ala794.D, His795.D, Leu798.D, Val799.D
6bcj_IC E -15.4 Trp860.C, Leu893.C, Leu900.C, Leu903.C, Ile916.C, Val919.C, Ser920.C, Phe932.D, Trp936.D, Leu1018.D, Leu1019.D, Val1022.D, Val1026.D, Leu1030.D
F -15.4 Trp860.A, Leu893.A, Leu900.A, Leu903.A, Ile916.A, Val919.A, Ser920.A, Phe932.C, Trp936.C, Leu1018.C, Leu1019.C, Val1022.C, Val1026.C, Leu1030.C
G -14.5 Phe927.A, Leu930.A, Phe931.A, Cys934.A, Asn909.B, Gln911.B, Leu912.B, Leu1018.C, Ile1021.C
H -14.5 Asn909.A, Leu912.A, Phe927.C, Leu930.C, Phe931.C, Cys934.C, Leu1018.D, Ile1021.D
I -13.9 Ile1021.B, Ile690.C, Phe906.C, Asn909.C, Leu912.C, Phe927.D, Leu930.D, Phe931.D, Cys934.D
J -14.7 Ile690.A, Leu694.A, Phe698.A, Phe779.A, Leu780.A, Val783.A, Val784.A, Leu787.A, Leu788.A, Phe906.A, Asn909.A
K -14.6 Ile690.B, Leu694.B, Phe698.B, Phe779.B, Leu780.B, Val783.B, Val784.B, Leu787.B, Phe906.B, Asn909.B
L -15.4 Phe932.B, Trp936.B, Leu1018.B, Leu1019.B, Val1022.B, Val1026.B, Leu1030.B, Trp860.D, Leu893.D, Leu900.D, Leu903.D, Ile916.D, Val919.D, Ser920.D
M -15.3 Phe932.A, Trp936.A, Leu1018.A, Leu1019.A, Val1022.A, Val1026.A, Leu1030.A, Trp860.B, Leu893.B, Leu900.B, Leu903.B, Ile916.B, Val919.B, Ser920.B
N -14.6 Leu1018.A, Ile1021.A, Phe927.B, Leu930.B, Phe931.B, Cys934.B, Asn909.D, Gln911.D, Leu912.D
O -14.7 Ile690.C, Leu694.C, Phe698.C, Phe779.C, Leu780.C, Val783.C, Val784.C, Leu787.C, Leu788.C, Phe906.C, Asn909.C
P -14.7 Ile690.D, Leu694.D, Phe698.D, Phe779.D, Leu780.D, Val783.D, Val784.D, Leu787.D, Leu788.D, Phe906.D, Asn909.D
TRPM4, closed, Mouse 6bcl
6bcl_EC E -15.7 Val1017.B, Ile1021.B, Cys934.D, Pro956.D, Leu959.D, Arg960.D, Phe963.D, Tyr964.D
F -15.6 Leu930.C, Pro956.C, Leu959.C, Arg960.C, Phe963.C, Tyr964.C, Val1017.D, Ile1021.D
G -14.2 Ser785.D, Leu788.D, Leu792.D, His795.D, Asp800.D, Ser809.D, Leu812.D, Trp816.D, Ala1072.D, Pro1074.D, Leu1075.D
H -14.2 Ser785.C, Leu788.C, Leu792.C, His795.C, Asp800.C, Ser809.C, Leu812.C, Trp816.C, Ala1072.C, Pro1074.C, Leu1075.C
I -14.2 Ser785.A, Leu788.A, Leu792.A, His795.A, Asp800.A, Ser809.A, Leu812.A, Trp816.A, Ala1072.A, Pro1074.A, Leu1075.A
J -13.5 Leu787.C, Leu791.C, Ala794.C, His795.C, Leu798.C, Val799.C, Leu902.C, Cys934.D, Val935.D, Val938.D, Val942.D, Leu955.D, Ile958.D, Leu959.D, Phe963.D
K -13.4 Leu791.A, Ala794.A, His795.A, Leu798.A, Val799.A, Cys934.C, Val935.C, Val938.C, Val942.C, Leu955.C, Ile958.C, Leu959.C, Phe963.C
L -12.3 Pro806.C, Leu811.C, Tyr814.C, Phe818.C, Leu821.C, Leu872.C, Val875.C, Leu879.C
M -12.3 Pro806.A, Leu811.A, Tyr814.A, Phe818.A, Leu821.A, Leu872.A, Val875.A, Leu879.A
N -12.3 Pro806.B, Leu811.B, Tyr814.B, Phe818.B, Leu821.B, Leu825.B, Leu872.B, Val875.B, Leu879.B
O -15.8 Val1017.A, Ile1021.A, Cys934.B, Pro956.B, Leu959.B, Arg960.B, Phe963.B, Tyr964.B
P -15.2 Cys934.A, Leu959.A, Arg960.A, Phe963.A, Tyr964.A, Trp1014.C, Val1017.C, Leu1018.C
Q -14.2 Ser785.B, Leu788.B, Leu792.B, His795.B, Asp800.B, Ser809.B, Leu812.B, Trp816.B, Ala1072.B, Pro1074.B, Leu1075.B
R -13.6 Cys934.A, Val935.A, Val938.A, Val942.A, Leu955.A, Ile958.A, Leu959.A, Phe963.A, Leu787.B, Leu791.B, Ala794.B, His795.B, Leu798.B, Val799.B, Leu902.B
S -13.6 Cys934.B, Val935.B, Val938.B, Val942.B, Leu955.B, Ile958.B, Leu959.B, Phe963.B, Leu787.D, Leu791.D, Ala794.D, His795.D, Leu798.D, Val799.D, Leu902.D
6bcl_IC E -15.2 Phe932.B, Trp936.B, Leu1018.B, Leu1019.B, Val1022.B, Trp860.D, Leu893.D, Leu900.D, Leu903.D, Ile916.D, Val917.D, Val919.D, Ser920.D, Met923.D
F -14.4 Asn909.A, Gln911.A, Leu912.A, Phe927.C, Leu930.C, Phe931.C, Cys934.C, Ile1021.D
G -14.4 Ile1021.B, Asn909.C, Gln911.C, Leu912.C, Phe927.D, Leu930.D, Phe931.D, Cys934.D
H -15.1 Trp860.C, Leu893.C, Leu900.C, Leu903.C, Ile916.C, Val919.C, Ser920.C, Met923.C, Phe932.D, Trp936.D, Leu1018.D, Leu1019.D, Val1022.D
I -14.9 Ile690.C, Leu694.C, Phe698.C, Phe779.C, Leu780.C, Val783.C, Val784.C, Leu787.C, Leu788.C, Phe906.C, Asn909.C
J -14.9 Ile690.A, Leu694.A, Phe698.A, Phe779.A, Leu780.A, Val783.A, Val784.A, Leu787.A, Leu788.A, Phe906.A, Asn909.A
K -13.5 Phe697.A, Trp772.A, Gly781.A, Val784.A, Ala1070.A, Leu1071.A, Ala1072.A, Leu1075.A
L -13.5 Phe697.C, Trp772.C, Gly781.C, Val784.C, Ala1070.C, Leu1071.C, Ala1072.C, Leu1075.C
M -13.9 Phe927.B, Leu930.B, Phe931.B, Cys934.B, Phe963.B, Ile690.D, Phe906.D, Asn909.D, Gln911.D, Leu912.D
N -15.2 Phe932.A, Trp936.A, Leu1018.A, Leu1019.A, Val1022.A, Trp860.B, Leu893.B, Leu900.B, Leu903.B, Ile916.B, Val919.B, Ser920.B, Met923.B
O -14.4 Phe927.A, Leu930.A, Phe931.A, Cys934.A, Asn909.B, Gln911.B, Leu912.B, Ile1021.C
P -15.7 Trp860.A, Leu893.A, Met896.A, Leu900.A, Leu903.A, Ile916.A, Val919.A, Ser920.A, Trp936.C, Leu1018.C, Leu1019.C, Val1022.C, Val1026.C, Leu1030.C
Q -14.9 Ile690.D, Leu694.D, Phe698.D, Phe779.D, Leu780.D, Val783.D, Val784.D, Leu787.D, Leu788.D, Phe906.D, Asn909.D
R -14.9 Ile690.B, Leu694.B, Phe698.B, Phe779.B, Leu780.B, Val783.B, Val784.B, Leu787.B, Leu788.B, Phe906.B, Asn909.B
S -13.5 Phe697.B, Trp772.B, Gly781.B, Val784.B, Leu788.B, Ala1070.B, Leu1071.B, Ala1072.B, Leu1075.B
T -13.5 Phe697.D, Trp772.D, Gly781.D, Val784.D, Leu788.D, Ala1070.D, Leu1071.D, Ala1072.D, Leu1075.D
TRPM4, closed, ATP bound, Mouse 6bco
6bco_EC E -15.3 Asp980.A, Trp1014.A, Val1017.A, Cys934.B, Leu959.B, Arg960.B, Phe963.B, Tyr964.B
F -15.0 Pro956.A, Leu959.A, Arg960.A, Phe963.A, Tyr964.A, Val1017.C, Leu1018.C, Ile1021.C
G -15.1 Leu930.C, Cys934.C, Leu959.C, Arg960.C, Phe963.C, Tyr964.C, Trp1014.D, Val1017.D, Leu1018.D, Ile1021.D
H -13.8 Ser785.B, Leu788.B, Leu792.B, His795.B, Asp800.B, Ser809.B, Leu812.B, Trp816.B, Ala1072.B, Pro1074.B, Leu1075.B
I -13.7 Ser785.A, Leu788.A, Leu792.A, His795.A, Asp800.A, Ser809.A, Leu812.A, Trp816.A, Ala1072.A, Pro1074.A, Leu1075.A
J -15.1 Val1017.B, Leu1018.B, Ile1021.B, Pro956.D, Ser957.D, Leu959.D, Arg960.D, Phe963.D, Tyr964.D
K -13.8 Ser785.D, Leu788.D, Leu792.D, His795.D, Asp800.D, Ser809.D, Leu812.D, Trp816.D, Ala1072.D, Pro1074.D, Leu1075.D
L -13.7 Ser785.C, Leu788.C, Leu792.C, His795.C, Asp800.C, Ser809.C, Leu812.C, Trp816.C, Ala1072.C, Pro1074.C, Leu1075.C
6bco_IC E -15.1 Phe927.B, Phe931.B, Cys934.B, Val938.B, Phe963.B, Asn909.D, Gln911.D, Leu912.D
F -14.8 Trp860.A, Leu893.A, Met896.A, Leu900.A, Leu903.A, Ile916.A, Val919.A, Ser920.A, Phe932.C, Trp936.C, Leu1015.C, Leu1019.C, Val1022.C, Val1026.C, Leu1030.C
G -14.8 Phe932.A, Trp936.A, Leu1015.A, Leu1019.A, Val1026.A, Leu1030.A, Trp860.B, Leu893.B, Leu900.B, Ile916.B, Val919.B, Ser920.B
H -14.5 Phe697.A, Trp772.A, Gly781.A, Val784.A, Ser785.A, Leu788.A, Ala1070.A, Leu1071.A, Ala1072.A, Leu1075.A
I -14.5 Phe697.B, Trp772.B, Gly781.B, Val784.B, Ser785.B, Leu788.B, Ala1070.B, Leu1071.B, Ala1072.B, Leu1075.B
J -14.3 Thr859.A, Trp860.A, Cys863.A, Leu893.A, Ile897.A, Leu1015.C, Leu1018.C, Leu1019.C, Val1022.C
K -15.2 Ile690.D, Leu694.D, Phe698.D, Leu780.D, Val784.D, Leu787.D, Leu788.D, Leu791.D, Phe906.D, Asn909.D
L -15.1 Phe927.A, Phe931.A, Cys934.A, Val938.A, Phe963.A, Asn909.B, Gln911.B, Leu912.B
M -14.5 Asn909.A, Leu912.A, Phe927.C, Leu930.C, Phe931.C, Cys934.C, Leu1018.D, Ile1021.D
N -14.9 Ile690.B, Leu694.B, Phe698.B, Phe779.B, Leu780.B, Val784.B, Leu787.B, Phe906.B, Asn909.B
O -13.6 Leu821.A, Glu824.A, Leu825.A, Gly828.A, Leu829.A, Leu852.A, Leu865.A, Thr869.A, Leu872.A, Leu873.A
P -13.6 Leu821.B, Glu824.B, Leu825.B, Gly828.B, Leu829.B, Leu852.B, Leu865.B, Thr869.B, Leu872.B, Leu873.B
Q -13.6 Phe818.A, Cys822.A, Leu825.A, Arg826.A, Leu829.A, Gly830.A, Ile1077.A, His1080.A, Leu1083.A, Leu1084.A
R -13.5 Phe818.B, Cys822.B, Leu825.B, Arg826.B, Leu829.B, Ile1077.B, His1080.B, Leu1083.B, Leu1084.B
S -13.6 Phe818.C, Cys822.C, Leu825.C, Arg826.C, Leu829.C, Ile1077.C, His1080.C, Leu1083.C, Leu1084.C
T -13.5 Phe818.D, Cys822.D, Leu825.D, Arg826.D, Leu829.D, Gly830.D, Ile1077.D, His1080.D, Leu1083.D, Leu1084.D
U -15.1 Asn909.C, Gln911.C, Leu912.C, Phe927.D, Phe931.D, Cys934.D, Val938.D, Phe963.D
V -14.8 Trp860.C, Leu893.C, Met896.C, Leu900.C, Leu903.C, Ile916.C, Val919.C, Ser920.C, Phe932.D, Trp936.D, Leu1015.D, Leu1019.D, Val1022.D, Val1026.D, Leu1030.D
W -14.8 Phe932.B, Trp936.B, Leu1015.B, Leu1019.B, Val1026.B, Leu1030.B, Trp860.D, Leu893.D, Leu900.D, Ile916.D, Val919.D, Ser920.D
X -14.7 Leu787.A, Leu902.A, Asn909.A, Gln911.A, Leu912.A, Phe927.C, Phe931.C, Cys934.C, Val938.C, Phe963.C
Y -14.5 Phe697.D, Trp772.D, Gly781.D, Val784.D, Ser785.D, Leu788.D, Ala1070.D, Leu1071.D, Ala1072.D, Leu1075.D
Z -14.5 Phe697.C, Trp772.C, Gly781.C, Val784.C, Ser785.C, Leu788.C, Ala1070.C, Leu1071.C, Ala1072.C, Leu1075.C
a -14.3 Thr859.C, Trp860.C, Cys863.C, Leu893.C, Ile897.C, Leu1015.D, Leu1018.D, Leu1019.D, Val1022.D
b -14.3 Leu1015.B, Leu1018.B, Leu1019.B, Val1022.B, Thr859.D, Trp860.D, Cys863.D, Leu893.D, Ile897.D
c -15.1 Ile690.C, Leu694.C, Phe698.C, Phe779.C, Leu780.C, Val784.C, Leu787.C, Leu788.C, Leu791.C, Phe906.C, Asn909.C
d -15.1 Ile690.A, Leu694.A, Phe698.A, Leu780.A, Val784.A, Leu787.A, Leu788.A, Leu791.A, Phe906.A, Asn909.A
g -13.6 Leu821.C, Glu824.C, Leu825.C, Gly828.C, Leu829.C, Leu852.C, Leu865.C, Thr869.C, Leu872.C, Leu873.C
h -13.6 Leu821.D, Glu824.D, Leu825.D, Gly828.D, Leu829.D, Leu852.D, Leu865.D, Thr869.D, Leu872.D, Leu873.D
TRPM4, closed, ATP bound, Mouse 6bcq
6bcq_EC E -15.7 Trp1014.B, Val1017.B, Leu1018.B, Ile1021.B, Pro956.D, Leu959.D, Arg960.D, Phe963.D, Tyr964.D
F -15.6 Pro956.C, Leu959.C, Arg960.C, Phe963.C, Tyr964.C, Val1017.D, Leu1018.D, Ile1021.D
G -15.4 Leu930.A, Cys934.A, Pro956.A, Leu959.A, Arg960.A, Phe963.A, Tyr964.A, Trp1014.C, Val1017.C, Leu1018.C, Ile1021.C
H -13.4 Ser785.C, Leu788.C, Leu792.C, His795.C, Asp800.C, Ser809.C, Leu812.C, Trp816.C, Ala1072.C, Pro1074.C, Leu1075.C
I -13.0 Ser785.A, Leu788.A, Leu792.A, His795.A, Asp800.A, Ser809.A, Leu812.A, Trp816.A, Ala1072.A, Pro1074.A, Leu1075.A
J -12.6 Leu866.A, Thr869.A, Leu873.A, Leu886.A, Thr889.A, Val890.A, Leu893.A, Tyr1011.C, Ala1012.C, Trp1014.C
K -12.4 Tyr1011.B, Ala1012.B, Trp1014.B, Leu866.D, Thr869.D, Leu873.D, Leu886.D, Thr889.D, Val890.D, Leu893.D
L -15.5 Val1017.A, Ile1021.A, Cys934.B, Pro956.B, Leu959.B, Arg960.B, Phe963.B, Tyr964.B
M -13.6 Ser785.D, Leu788.D, Leu791.D, Leu792.D, His795.D, Asp800.D, Ser809.D, Leu812.D, Trp816.D, Ala1072.D, Pro1074.D, Leu1075.D
N -12.7 Ser785.B, Leu788.B, Leu792.B, His795.B, Asp800.B, Ser809.B, Leu812.B, Trp816.B, Ala1072.B, Pro1074.B, Leu1075.B
O -12.6 Tyr1011.A, Ala1012.A, Trp1014.A, Leu866.B, Thr869.B, Leu873.B, Leu886.B, Thr889.B, Val890.B, Leu893.B
6bcq_IC E -15.1 Leu821.C, Glu824.C, Leu825.C, Gly828.C, Leu829.C, Leu852.C, Leu865.C, Leu868.C, Thr869.C, Leu872.C, Leu873.C
F -15.0 Thr859.A, Trp860.A, Cys863.A, Leu866.A, Leu893.A, Ile897.A, Leu900.A, Leu1015.C, Leu1019.C
G -14.8 Thr859.C, Trp860.C, Cys863.C, Leu866.C, Leu893.C, Ile897.C, Leu900.C, Leu1015.D, Leu1019.D
H -14.7 Leu821.A, Glu824.A, Leu825.A, Gly828.A, Leu829.A, Leu852.A, Leu865.A, Thr869.A, Leu872.A, Leu873.A
I -14.5 Leu791.A, Gln911.A, Leu912.A, Phe927.C, Phe931.C, Cys934.C, Val938.C, Phe963.C
K -14.9 Ile690.A, Leu694.A, Phe698.A, Phe779.A, Val783.A, Val784.A, Leu787.A, Phe906.A, Asn909.A
L -14.6 Phe927.A, Leu930.A, Phe931.A, Cys934.A, Phe906.B, Asn909.B, Leu912.B, Leu1018.C, Ile1021.C
M -14.5 Phe697.A, Trp772.A, Gly781.A, Val784.A, Ala1070.A, Leu1071.A, Ala1072.A, Leu1075.A
N -14.5 Phe697.C, Trp772.C, Thr777.C, Gly781.C, Val784.C, Leu788.C, Ala1070.C, Leu1071.C, Ala1072.C, Leu1075.C
O -14.3 Phe818.C, Cys822.C, Leu825.C, Arg826.C, Leu829.C, Ile1077.C, His1080.C, Val1081.C, Leu1084.C
P -14.2 Asn909.C, Gln911.C, Leu912.C, Phe927.D, Leu930.D, Phe931.D, Cys934.D, Phe963.D
Q -13.9 Phe818.A, Cys822.A, Leu825.A, Arg826.A, Leu829.A, Ile1077.A, His1080.A, Val1081.A, Leu1084.A
R -13.8 Ile690.B, Leu694.B, Phe698.B, Phe779.B, Leu780.B, Val783.B, Val784.B, Leu787.B, Phe906.B, Asn909.B
S -14.1 Ile690.C, Leu694.C, Phe698.C, Phe779.C, Leu780.C, Val783.C, Val784.C, Leu787.C, Phe906.C, Asn909.C
T -15.3 Leu1015.B, Leu1019.B, Thr859.D, Trp860.D, Cys863.D, Leu866.D, Leu893.D, Ile897.D, Leu900.D
U -14.8 Phe697.B, Trp772.B, Gly781.B, Val784.B, Leu788.B, Ala1070.B, Leu1071.B, Ala1072.B, Leu1075.B
V -14.6 Leu1015.A, Leu1018.A, Leu1019.A, Val1022.A, Thr859.B, Trp860.B, Cys863.B, Leu893.B, Ile897.B, Leu900.B
X -14.8 Leu821.B, Glu824.B, Leu825.B, Gly828.B, Leu829.B, Leu852.B, Leu865.B, Thr869.B, Leu872.B, Leu873.B
Y -14.1 Phe927.B, Leu930.B, Phe931.B, Cys934.B, Phe963.B, Asn909.D, Gln911.D, Leu912.D
Z -14.3 Phe697.D, Trp772.D, Thr777.D, Ala778.D, Gly781.D, Ser785.D, Leu788.D, Ala1070.D, Leu1071.D, Ala1072.D, Leu1075.D
a -14.3 Leu821.D, Glu824.D, Leu825.D, Gly828.D, Leu829.D, Leu852.D, Leu865.D, Leu868.D, Thr869.D, Leu872.D, Leu873.D
b -14.0 Phe818.B, Cys822.B, Leu825.B, Arg826.B, Leu829.B, Ile1077.B, His1080.B, Val1081.B, Leu1083.B, Leu1084.B
c -14.0 Ile690.D, Leu694.D, Phe698.D, Leu780.D, Val784.D, Leu787.D, Phe906.D, Asn909.D
TRPM4, closed, Human 6bqr
6bqr_EC E -15.0 Val1021.A, Leu1022.A, Val1025.A, Leu934.B, Phe935.B, Leu963.B, Arg964.B, Phe967.B, Tyr968.B
F -14.9 Val1021.B, Leu1022.B, Val1025.B, Leu934.D, Phe935.D, Pro960.D, Leu963.D, Arg964.D, Phe967.D, Tyr968.D
G -13.9 Leu792.C, Leu795.C, Leu796.C, Arg799.C, Leu813.C, Trp820.C, Ala1076.C, Phe1079.C
H -13.8 Leu792.D, Leu795.D, Leu796.D, Arg799.D, Leu813.D, Trp820.D, Ala1076.D, Phe1079.D
I -13.3 Leu791.C, Leu795.C, Ser798.C, Arg799.C, Leu802.C, Val803.C, Val942.D, Val946.D, Phe959.D, Ile962.D, Leu963.D, Val966.D, Phe967.D
J -14.9 Leu934.C, Phe935.C, Leu963.C, Arg964.C, Phe967.C, Tyr968.C, Val1021.D, Leu1022.D, Val1025.D
K -13.1 Phe822.B, Leu825.B, Leu829.B, Leu876.B, Val879.B, Gly880.B, Leu883.B, Thr884.B
L -13.1 Phe822.D, Leu825.D, Leu829.D, Leu876.D, Val879.D, Gly880.D, Leu883.D, Thr884.D
M -12.6 Tyr1015.A, Trp1018.A, Leu1019.A, Val870.B, Leu890.B, Thr893.B, Val894.B, Ile897.B, Val901.B
N -12.4 Tyr1015.B, Trp1018.B, Leu1019.B, Val870.D, Leu890.D, Thr893.D, Val894.D, Ile897.D
O -13.3 Val942.B, Val946.B, Phe959.B, Ile962.B, Leu963.B, Val966.B, Phe967.B, Leu791.D, Leu795.D, Ser798.D, Arg799.D, Leu802.D, Val803.D
P -14.9 Leu934.A, Phe935.A, Leu963.A, Arg964.A, Phe967.A, Tyr968.A, Val1021.C, Leu1022.C, Val1025.C
Q -13.7 Leu792.B, Leu795.B, Leu796.B, Arg799.B, Leu813.B, Trp820.B, Ala1076.B, Phe1079.B
R -13.6 Leu792.A, Leu795.A, Leu796.A, Arg799.A, Leu813.A, Trp820.A, Ala1076.A, Phe1079.A
S -13.1 Phe822.C, Leu825.C, Leu829.C, Leu876.C, Val879.C, Gly880.C, Cys881.C, Leu883.C, Thr884.C
T -12.8 Val942.A, Val946.A, Phe959.A, Ile962.A, Leu963.A, Val966.A, Phe967.A, Leu791.B, Leu795.B, Ser798.B, Arg799.B, Leu802.B, Val803.B
U -12.8 Phe822.A, Leu825.A, Leu829.A, Leu876.A, Val879.A, Gly880.A, Leu883.A, Thr884.A
V -12.4 Val870.A, Leu890.A, Thr893.A, Val894.A, Ile897.A, Tyr1015.C, Trp1018.C, Leu1019.C
W -13.2 Leu791.A, Leu795.A, Ser798.A, Arg799.A, Leu802.A, Val803.A, Val942.C, Val946.C, Phe959.C, Ile962.C, Leu963.C, Val966.C, Phe967.C
X -13.1 Leu869.C, Val870.C, Thr873.C, Cys874.C, Leu877.C, Leu890.C, Thr893.C, Val894.C, Trp1018.D, Leu1019.D
6bqr_IC E -15.5 Gln915.C, Leu916.C, Lys928.D, Phe931.D, Leu934.D, Phe935.D, Leu941.D, Phe967.D
F -15.4 Lys928.B, Phe931.B, Leu934.B, Phe935.B, Leu941.B, Phe967.B, Ile690.D, Gln915.D, Leu916.D
G -14.7 Phe936.A, Trp940.A, Leu1023.A, Ile1026.A, Trp864.B, Ile897.B, Val904.B, Leu907.B, Ile920.B, Val921.B, Val923.B, Ser924.B, Met927.B
H -15.2 Trp680.C, Ile690.C, Leu693.C, Phe698.C, Phe783.C, Met784.C, Val787.C, Val788.C, Leu791.C, Phe910.C, Asn913.C
I -15.1 Trp680.D, Ile690.D, Leu693.D, Phe698.D, Phe783.D, Met784.D, Val787.D, Val788.D, Leu791.D, Phe910.D, Asn913.D
J -14.5 Phe936.B, Trp940.B, Ile1026.B, Trp864.D, Ile897.D, Val904.D, Leu907.D, Ile920.D, Val921.D, Val923.D, Ser924.D, Met927.D
K -15.3 Lys928.A, Phe931.A, Leu934.A, Phe935.A, Leu941.A, Phe967.A, Gln915.B, Leu916.B
L -15.2 Gln915.A, Leu916.A, Lys928.C, Phe931.C, Leu934.C, Phe935.C, Leu941.C, Phe967.C
M -14.6 Trp864.C, Ile897.C, Val904.C, Leu907.C, Ile920.C, Val921.C, Val923.C, Ser924.C, Met927.C, Phe936.D, Trp940.D, Ile1026.D
N -15.1 Trp680.A, Ile690.A, Leu693.A, Phe698.A, Phe783.A, Met784.A, Val787.A, Val788.A, Leu791.A, Phe910.A, Asn913.A
O -15.1 Trp680.B, Ile690.B, Leu693.B, Phe698.B, Phe783.B, Met784.B, Val787.B, Val788.B, Leu791.B, Phe910.B, Asn913.B
P -14.4 Trp864.A, Ile897.A, Val904.A, Leu907.A, Ile920.A, Val921.A, Val923.A, Ser924.A, Met927.A, Phe936.C, Trp940.C, Ile1026.C
TRPM4, closed, Ca bound, Human 6bqv
6bqv_EC E -15.0 Trp1018.A, Val1021.A, Leu1022.A, Val1025.A, Leu934.B, Phe935.B, Leu963.B, Arg964.B, Phe967.B, Tyr968.B
F -15.0 Leu934.A, Phe935.A, Leu963.A, Arg964.A, Phe967.A, Tyr968.A, Val1021.C, Leu1022.C, Val1025.C
G -12.8 Tyr1015.A, Trp1018.A, Leu1019.A, Val870.B, Leu890.B, Thr893.B, Val894.B, Ile897.B
H -12.8 Val870.A, Leu890.A, Thr893.A, Val894.A, Ile897.A, Tyr1015.C, Ala1016.C, Trp1018.C, Leu1019.C
I -15.0 Leu934.C, Phe935.C, Leu963.C, Arg964.C, Phe967.C, Tyr968.C, Val1021.D, Leu1022.D, Val1025.D
J -15.0 Val1021.B, Leu1022.B, Val1025.B, Leu934.D, Phe935.D, Leu963.D, Arg964.D, Phe967.D, Tyr968.D
K -12.8 Val870.C, Leu890.C, Thr893.C, Val894.C, Ile897.C, Tyr1015.D, Trp1018.D, Leu1019.D
L -12.8 Tyr1015.B, Trp1018.B, Leu1019.B, Val870.D, Leu890.D, Thr893.D, Val894.D, Ile897.D
6bqv_IC E -15.3 Ile897.A, Met900.A, Val904.A, Leu907.A, His908.A, Ile920.A, Val921.A, Val923.A, Ser924.A, Phe936.C, Trp940.C, Leu1023.C
F -15.3 Phe936.A, Trp940.A, Leu1023.A, Ile897.B, Met900.B, Val904.B, Leu907.B, His908.B, Ile920.B, Val921.B, Val923.B, Ser924.B
G -14.8 Phe931.A, Leu934.A, Phe935.A, Phe967.A, Phe910.B, Asn913.B, Gln915.B, Leu916.B
H -14.6 Ile690.D, Phe698.D, Phe783.D, Met784.D, Val787.D, Val788.D, Leu791.D, Leu795.D, Phe910.D, Asn913.D
I -14.9 Phe931.B, Leu934.B, Phe935.B, Gly938.B, Val942.B, Phe967.B, Ile690.D, Asn913.D, Gln915.D, Leu916.D
J -14.0 Trp680.B, Ile690.B, Val780.B, Phe783.B, Met784.B, Val787.B, Val788.B, Leu791.B, Leu795.B, Phe910.B, Asn913.B
K -15.3 Ile897.C, Met900.C, Val904.C, Leu907.C, His908.C, Ile920.C, Val921.C, Val923.C, Ser924.C, Phe936.D, Trp940.D, Leu1023.D
L -14.6 Ile690.A, Phe698.A, Phe783.A, Met784.A, Val787.A, Val788.A, Leu791.A, Leu795.A, Phe910.A, Asn913.A
M -14.6 Trp680.C, Ile690.C, Phe698.C, Phe783.C, Met784.C, Val787.C, Val788.C, Leu791.C, Leu795.C, Phe910.C, Asn913.C
N -14.1 Val1025.B, Phe910.C, Asn913.C, Gln915.C, Leu916.C, Phe931.D, Leu934.D, Phe935.D, Gly938.D, Leu941.D, Phe967.D
O -14.9 Ile690.A, Asn913.A, Gln915.A, Leu916.A, Phe931.C, Leu934.C, Phe935.C, Gly938.C, Val942.C, Phe967.C
TRPM4, closed, Human 6bwi
6bwi_EC E -14.2 Asn1017.A, Trp1018.A, Val1021.A, Leu1022.A, Leu963.D, Arg964.D, Phe967.D, Tyr968.D
F -13.9 Leu934.A, Phe935.A, Leu963.A, Arg964.A, Phe967.A, Tyr968.A, Trp1018.B, Val1021.B, Leu1022.B, Val1025.B
G -13.0 Pro810.A, Leu815.A, Tyr818.A, Phe819.A, Phe822.A, Leu883.A, Ile1080.A, Val1081.A, Leu1085.A
H -13.0 Pro810.C, Leu815.C, Tyr818.C, Phe819.C, Phe822.C, Leu883.C, Ile1080.C, Val1081.C, Leu1085.C
I -15.2 Gly938.C, Leu963.C, Phe967.C, Tyr968.C, Asn1017.D, Trp1018.D, Val1021.D, Leu1022.D, Val1025.D
J -12.7 Pro810.D, Leu815.D, Phe819.D, Phe822.D, Cys826.D, Ile1080.D, Val1081.D, His1084.D, Leu1085.D
K -13.9 Leu934.B, Phe935.B, Pro960.B, Arg964.B, Phe967.B, Tyr968.B, Trp1018.C, Val1021.C, Leu1022.C, Val1025.C
L -12.6 Pro810.B, Leu815.B, Phe819.B, Phe822.B, Cys826.B, Leu883.B, Ile1080.B, Val1081.B, His1084.B, Leu1085.B
6bwi_IC E -14.5 Ile690.D, Met784.D, Val787.D, Val788.D, Leu791.D, Leu795.D, Phe910.D, Asn913.D, Leu916.D
F -14.5 Ile690.C, Met784.C, Val787.C, Val788.C, Leu791.C, Leu795.C, Phe910.C, Asn913.C, Gln915.C, Leu916.C
G -14.1 Trp864.A, Ile897.A, Met900.A, Val904.A, Leu907.A, Ile920.A, Val921.A, Val923.A, Ser924.A, Met927.A, Phe936.B, Trp940.B, Leu1023.B
H -14.1 Trp864.C, Ile897.C, Met900.C, Val904.C, Leu907.C, Ile920.C, Val921.C, Val923.C, Ser924.C, Met927.C, Phe936.D, Trp940.D, Leu1023.D
I -14.0 Phe936.A, Trp940.A, Leu1023.A, Trp864.D, Ile897.D, Met900.D, Val904.D, Leu907.D, Ile920.D, Val921.D, Val923.D, Ser924.D, Met927.D
J -13.7 Phe931.A, Leu934.A, Phe935.A, Gly938.A, Leu941.A, Phe967.A, Val1025.B, Ile690.D, Leu916.D
K -13.6 Val1025.A, Ile690.C, Leu916.C, Phe931.D, Leu934.D, Phe935.D, Gly938.D, Leu941.D, Phe967.D
L -13.6 Ser863.C, Trp864.C, Cys867.C, Ile897.C, Val901.C, Leu1019.D, Leu1022.D, Leu1023.D
M -13.6 Ser863.A, Trp864.A, Cys867.A, Ile897.A, Val901.A, Leu1019.B, Leu1022.B, Leu1023.B
N -14.7 Ile690.A, Met784.A, Val787.A, Val788.A, Leu791.A, Leu795.A, Phe910.A, Asn913.A, Leu916.A
O -14.2 Ile690.B, Met784.B, Val787.B, Val788.B, Leu791.B, Leu795.B, Phe910.B, Asn913.B, Leu916.B
P -14.2 Trp864.B, Ile897.B, Met900.B, Val904.B, Leu907.B, Ile920.B, Val921.B, Val923.B, Ser924.B, Met927.B, Phe936.C, Trp940.C, Leu1023.C
Q -13.5 Ser863.B, Trp864.B, Cys867.B, Ile897.B, Val901.B, Leu1019.C, Leu1022.C, Leu1023.C
R -14.5 Ile690.B, Phe931.C, Leu934.C, Phe935.C, Leu937.C, Gly938.C, Leu941.C, Phe967.C
S -14.4 Ile690.A, Phe931.B, Leu934.B, Phe935.B, Leu937.B, Gly938.B, Leu941.B, Phe967.B
TRPM7
TRPM7, closed, Mouse 5zx5
5zx5_EC E -13.4 Leu1012.B, Pro1028.B, Ser1029.B, Trp1030.B, Leu1032.B, Ala1033.B, Ile1036.B, Leu864.C, Met868.C, Thr871.C, Phe872.C, Leu875.C, Leu976.C
F -13.1 Phe894.A, Ala897.A, Ile932.A, Phe936.A, Phe939.A, Gly940.A, Phe943.A, Gly944.A
G -13.1 Phe894.C, Ala897.C, Ile932.C, Phe936.C, Phe939.C, Gly940.C, Phe943.C, Gly944.C
H -14.6 Leu864.A, Met868.A, Thr871.A, Phe872.A, Leu976.A, Leu1012.D, Pro1028.D, Ser1029.D, Trp1030.D, Leu1032.D, Ala1033.D, Ile1036.D
I -14.3 Leu1012.C, Pro1028.C, Ser1029.C, Trp1030.C, Leu1032.C, Ala1033.C, Ile1036.C, Leu864.D, Met868.D, Thr871.D, Phe872.D, Leu875.D, Leu976.D
J -12.6 Ile933.B, Phe936.B, Val937.B, Gly940.B, Leu941.B, Gly944.B, Ala945.B, Lys946.B, Val957.B
K -14.2 Leu1012.A, Pro1028.A, Ser1029.A, Trp1030.A, Leu1032.A, Ala1033.A, Ile1036.A, Leu864.B, Met868.B, Thr871.B, Phe872.B, Leu976.B
L -13.8 Phe894.D, Ala897.D, Ile898.D, Ile932.D, Phe936.D, Phe939.D, Gly940.D, Phe943.D, Gly944.D
5zx5_IC E -16.3 Leu1072.A, Leu1076.A, Val1079.A, Val1083.A, Phe924.B, Leu967.B, Ile970.B, Phe971.B, Val974.B, Val990.B, Ile993.B, Gly994.B, Val997.B
F -16.1 Leu1076.B, Val1079.B, Val1083.B, Phe924.C, Leu967.C, Ile970.C, Phe971.C, Val974.C, Val990.C, Ile993.C, Gly994.C, Val997.C
G -16.0 Phe924.A, Leu967.A, Ile970.A, Phe971.A, Val974.A, Val990.A, Ile993.A, Gly994.A, Val997.A, Leu1072.D, Leu1076.D, Val1079.D, Val1083.D
H -15.2 Val1005.B, Leu1009.B, Leu1012.B, Ile1036.B, Val1037.B, Phe856.C, Trp857.C, Thr860.C, Leu864.C, Leu976.C, Phe979.C, Leu980.C, Val982.C
I -15.0 Val1005.A, Leu1009.A, Leu1012.A, Val1037.A, Phe856.B, Leu864.B, Leu976.B, Phe979.B, Leu980.B, Val982.B
J -13.8 Phe1075.B, Ala1078.B, Val1079.B, Phe1082.B, Val997.C, Ala998.C, Phe1001.C, Val1004.C, Val1037.C, Tyr1041.C
K -13.5 Val997.A, Ala998.A, Phe1001.A, Val1004.A, Val1037.A, Tyr1041.A, Phe1075.D, Ala1078.D, Val1079.D, Phe1082.D
L -13.4 Phe1075.A, Ala1078.A, Val1079.A, Phe1082.A, Val997.B, Ala998.B, Phe1001.B, Val1004.B, Val1037.B, Tyr1041.B
M -16.1 Leu1076.B, Val1079.B, Val1083.B, Phe924.C, Leu967.C, Ile970.C, Phe971.C, Val974.C, Val990.C, Ile993.C, Gly994.C, Val997.C
N -16.0 Phe924.A, Leu967.A, Ile970.A, Phe971.A, Val974.A, Val990.A, Ile993.A, Gly994.A, Lys995.A, Val997.A, Leu1072.D, Leu1076.D, Val1079.D, Val1083.D
O -15.6 Leu1076.C, Val1079.C, Val1083.C, Phe924.D, Leu967.D, Ile970.D, Phe971.D, Val974.D, Val990.D, Ile993.D, Gly994.D, Val997.D
P -15.4 Val1005.C, Leu1009.C, Leu1012.C, Val1037.C, Phe856.D, Trp857.D, Thr860.D, Leu864.D, Leu976.D, Phe979.D, Leu980.D, Val982.D
Q -15.0 Phe856.A, Thr860.A, Leu864.A, Leu976.A, Phe979.A, Leu980.A, Val982.A, Val1005.D, Leu1009.D, Leu1012.D, Val1037.D
R -13.8 Phe1075.B, Ala1078.B, Val1079.B, Phe1082.B, Val997.C, Ala998.C, Phe1001.C, Val1004.C, Val1037.C, Tyr1041.C
S -13.5 Gly994.A, Val997.A, Ala998.A, Phe1001.A, Val1004.A, Val1037.A, Tyr1041.A, Phe1075.D, Ala1078.D, Val1079.D, Phe1082.D
T -13.5 Phe1075.C, Ala1078.C, Val1079.C, Phe1082.C, Val997.D, Ala998.D, Met1000.D, Phe1001.D, Val1004.D, Val1037.D, Tyr1041.D
TRPM8
TRPM8, closed, Collared Flycatcher, 6bpq
6bpq_EC [none]
6bpq_IC [none]
TRPM8, closed, with PtdIns(4,5)P2 and menthol analogue, Collared Flycatcher 6nr2
6nr2_EC E -14.9 Phe871.A, Val875.A, Val878.A, Val882.A, Trp895.A, Ile898.A, Phe899.A, Val902.A, Leu750.B, Ala753.B, Leu757.B, Leu842.B
F -14.9 Leu750.A, Ala753.A, Leu757.A, Leu842.A, Phe871.D, Val875.D, Val878.D, Val882.D, Trp895.D, Ile898.D, Phe899.D, Val902.D
G -14.1 Trp876.A, Phe880.A, Arg884.A, Ala909.A, Met910.A, Tyr962.A, Thr966.A, Leu969.A, Leu970.A, Phe911.B
H -13.9 Phe911.A, Trp876.D, Phe880.D, Arg884.D, Ala909.D, Met910.D, Tyr962.D, Leu970.D
I -13.9 Trp876.C, Phe880.C, Arg884.C, Ala909.C, Met910.C, Tyr962.C, Leu970.C, Phe911.D
J -12.8 Trp953.C, Leu804.D, Phe807.D, Tyr808.D, Ala811.D, Phe815.D, Ser826.D, Ile830.D
K -12.7 Leu804.A, Phe807.A, Tyr808.A, Ala811.A, Phe815.A, Ser826.A, Ile830.A, Trp953.D
L -14.9 Phe871.B, Val875.B, Val878.B, Val882.B, Trp895.B, Ile898.B, Phe899.B, Val902.B, Leu750.C, Ala753.C, Leu757.C, Leu842.C
M -14.8 Phe871.C, Val875.C, Val878.C, Val882.C, Trp895.C, Ile898.C, Phe899.C, Val902.C, Leu750.D, Ala753.D, Leu757.D, Leu842.D
N -13.9 Trp876.B, Phe880.B, Arg884.B, Ala909.B, Met910.B, Tyr962.B, Leu970.B, Phe911.C
O -12.8 Trp953.B, Leu804.C, Phe807.C, Tyr808.C, Ala811.C, Phe815.C, Ser826.C, Ile830.C
P -12.8 Trp953.A, Leu804.B, Phe807.B, Tyr808.B, Ala811.B, Phe815.B, Ser826.B, Ile830.B
6nr2_IC E -13.5 Leu797.A, Ile864.A, Phe867.A, Phe868.A, Phe871.A, Ile956.D, Val959.D, Cys960.D, Met963.D
F -13.5 Ile956.C, Val959.C, Cys960.C, Met963.C, Leu797.D, Ile864.D, Phe867.D, Phe868.D, Phe871.D
G -13.5 Ile956.B, Val959.B, Cys960.B, Met963.B, Leu797.C, Ile864.C, Phe867.C, Phe868.C, Phe871.C
H -13.5 Ile956.A, Val959.A, Cys960.A, Met963.A, Leu797.B, Ile864.B, Phe867.B, Phe868.B, Phe871.B
TRPM8, closed, with PtdIns(4,5)P2 and icilin, Collared Flycatcher 6nr3
6nr3_EC E -13.8 Phe871.B, Val875.B, Val878.B, Val882.B, Ile898.B, Phe899.B, Val902.B, Ile746.C, Leu750.C, Ala753.C, Tyr754.C, Leu757.C, Leu842.C, Phe846.C
F -13.7 Phe871.C, Val875.C, Val878.C, Val882.C, Ile898.C, Phe899.C, Val902.C, Ile746.D, Leu749.D, Leu750.D, Ala753.D, Tyr754.D, Leu757.D, Leu842.D, Phe846.D
G -13.6 Ala909.B, Met910.B, Gly912.B, Tyr962.B, Ser965.B, Thr966.B, Leu969.B, Leu970.B, Phe911.C, Leu969.C
H -13.3 Leu908.A, Ala909.A, Met910.A, Gly912.A, Tyr962.A, Leu969.A, Leu970.A, Phe911.B, Leu969.B, Leu973.B
I -13.3 Leu908.C, Ala909.C, Met910.C, Phe911.C, Gly912.C, Tyr962.C, Leu969.C, Leu970.C, Phe911.D, Leu969.D, Leu973.D
J -13.1 Phe911.A, Leu969.A, Leu973.A, Ala909.D, Met910.D, Phe911.D, Gly912.D, Tyr962.D, Leu969.D, Leu970.D
K -13.9 Phe871.A, Val875.A, Val878.A, Val882.A, Ile898.A, Phe899.A, Val902.A, Ile746.B, Leu750.B, Ala753.B, Tyr754.B, Leu757.B, Leu842.B, Phe846.B
L -13.8 Ile746.A, Leu749.A, Leu750.A, Ala753.A, Tyr754.A, Leu757.A, Leu842.A, Phe846.A, Phe871.D, Val875.D, Val878.D, Val882.D, Ile898.D, Phe899.D, Val902.D
6nr3_IC E -14.3 Ile956.A, Leu797.B, Met801.B, Leu804.B, Leu833.B, Val837.B, Gln860.B, Met863.B, Ile864.B, Phe867.B
F -14.3 Ile956.B, Leu797.C, Met801.C, Leu804.C, Leu833.C, Val837.C, Gln860.C, Arg861.C, Met863.C, Ile864.C, Phe867.C
G -13.6 Ile696.C, Leu699.C, Phe700.C, Phe735.C, Phe738.C, Ser739.C, Val742.C, Ile743.C, Ile746.C
H -13.6 Ile696.D, Phe700.D, Phe735.D, Phe738.D, Ser739.D, Val742.D, Ile743.D, Ile746.D
I -14.3 Leu797.A, Met801.A, Leu804.A, Leu833.A, Val837.A, Gln860.A, Met863.A, Ile864.A, Phe867.A, Ile956.D
J -14.3 Ile956.C, Leu797.D, Met801.D, Leu804.D, Leu833.D, Val837.D, Gln860.D, Met863.D, Ile864.D, Phe867.D
K -13.6 Ile696.B, Leu699.B, Phe700.B, Phe735.B, Phe738.B, Ser739.B, Val742.B, Ile743.B, Ile746.B
L -13.6 Ile696.A, Leu699.A, Phe700.A, Phe735.A, Phe738.A, Ser739.A, Val742.A, Ile743.A, Ile746.A
TRPM8, closed, with PtdIns(4,5)P2 and icilin, Collared Flycatcher,6nr4
6nr4_EC [none]
6nr4_IC E -13.4 Ile956.A, Val959.A, Met963.A, Leu797.B, Ile864.B, Phe867.B, Phe868.B, Phe871.B, Ala874.B, Tyr907.B
F -13.3 Ile956.B, Val959.B, Cys960.B, Met963.B, Leu797.C, Ile864.C, Phe867.C, Phe868.C, Phe871.C, Arg850.D
G -12.8 Leu970.A, Leu973.A, Leu974.A, Met977.A, Phe978.A, Leu973.B, Leu974.B, Met977.B, Phe978.B, Met977.C, Phe978.C, Leu974.D, Met977.D, Phe978.D
H -12.7 Leu973.A, Leu974.A, Met977.A, Phe978.A, Met977.B, Phe978.B, Leu974.C, Met977.C, Phe978.C, Leu973.D, Leu974.D, Met977.D, Phe978.D
I -13.3 Leu797.A, Ile864.A, Phe867.A, Phe868.A, Phe871.A, Tyr907.A, Ile956.D, Val959.D, Met963.D
J -13.3 Ile956.C, Val959.C, Met963.C, Leu797.D, Ile864.D, Phe867.D, Phe868.D, Phe871.D, Ala874.D, Tyr907.D
TRPML1
TRPML1, closed, Human 5wj5
5wj5_EC E -13.3 Ile73.A, Leu74.A, Ile81.A, Trp398.A, Gln484.C, Trp491.C, Phe441.D, Leu457.D, Ser458.D
F -13.2 Phe441.A, Leu457.A, Ser458.A, Ile73.B, Leu74.B, Ile81.B, Trp398.B, Gln484.D, Trp491.D
G -13.0 Ala433.A, Tyr436.A, Leu437.A, Ser456.A, Leu457.A, Ser458.A, Ser461.A, Trp491.D, Tyr499.D
H -12.9 Leu85.A, Trp491.C, Tyr499.C, Ala433.D, Tyr436.D, Leu437.D, Ser456.D, Leu457.D, Ser458.D, Ser461.D
I -12.8 Trp491.B, Tyr499.B, Ala433.C, Tyr436.C, Leu437.C, Ser456.C, Leu457.C, Ser458.C, Ser461.C, Leu85.D
J -12.7 Gln484.B, Trp491.B, Phe441.C, Ser456.C, Leu457.C, Ser458.C, Ile73.D, Leu74.D, Ile81.D, Trp398.D
K -13.1 Gln484.A, Trp491.A, Phe441.B, Leu457.B, Ser458.B, Ile73.C, Leu74.C, Ile81.C, Trp398.C
L -13.0 Trp491.A, Tyr499.A, Ala433.B, Tyr436.B, Leu437.B, Ser456.B, Leu457.B, Ser458.B, Ser461.B
5wj5_IC E -15.2 Leu357.A, Ile388.A, Thr392.A, Leu395.A, Leu396.A, Val399.A, Arg403.A, Arg419.A, Leu422.A, Phe493.D, Leu496.D
F -13.7 Leu492.C, Phe493.C, Leu496.C, Gly353.D, Ile356.D, Leu357.D, Thr360.D, Leu396.D
G -13.6 Phe493.C, Leu496.C, Ile388.D, Thr392.D, Leu396.D, Leu418.D, Arg419.D, Leu422.D
H -12.8 Val434.B, Val70.C, Ile73.C, Leu74.C, Ile81.C, Trp398.C, Val401.C, Tyr404.C, Leu405.C, Phe408.C
I -12.9 Val434.A, Val70.B, Ile73.B, Leu74.B, Ile81.B, Trp398.B, Val401.B, Tyr404.B, Leu405.B, Phe408.B
J -12.9 Val70.A, Ile73.A, Leu74.A, Ile81.A, Trp398.A, Val401.A, Tyr404.A, Leu405.A, Phe408.A, Val434.D
K -12.8 Val70.D, Ile73.D, Leu74.D, Ile81.D, Trp398.D, Val401.D, Tyr404.D, Leu405.D, Phe408.D
L -12.6 Ile356.A, Leu357.A, Thr360.A, Leu364.A, Val385.A, Ile388.A, Leu389.A, Leu489.D
M -14.9 Phe493.A, Leu496.A, Leu357.B, Ile388.B, Thr392.B, Leu396.B, Val399.B, Arg403.B, Arg419.B
N -13.8 Phe493.B, Leu496.B, Ile388.C, Thr392.C, Leu396.C, Leu418.C, Arg419.C, Leu422.C
O -12.6 Ile356.C, Leu357.C, Thr360.C, Leu364.C, Val385.C, Leu389.C, Thr392.C, Leu396.C
TRPML1, open, with agonist, Human  5wj9
5wj9_EC E -13.4 Phe441.B, Trp444.B, Ile73.C, Leu74.C, Thr77.C, Val78.C, Ile81.C, Trp398.C
F -12.4 Phe441.A, Trp444.A, Ile73.B, Leu74.B, Thr77.B, Val78.B, Ile81.B, Leu85.B, Trp398.B
G -12.2 Thr77.A, Val78.A, Ile81.A, Leu82.A, Leu85.A, Trp398.A, Leu437.D, Phe441.D, Trp444.D, Leu457.D
H -12.0 Leu437.C, Phe441.C, Trp444.C, Thr77.D, Val78.D, Ile81.D, Leu82.D, Leu85.D, Trp398.D
5wj9_IC E -13.5 Leu492.C, Phe493.C, Leu496.C, Gly353.D, Ile356.D, Leu357.D, Thr360.D, Ile388.D, Thr392.D, Leu396.D
F -13.4 Leu492.B, Phe493.B, Leu496.B, Gly353.C, Ile356.C, Leu357.C, Thr360.C, Ile388.C, Thr392.C, Leu396.C, Arg419.C
G -13.0 Gln495.C, Tyr499.C, Met508.C, Leu418.D, Leu422.D, Val425.D, Met426.D, Cys429.D, Ser461.D
H -13.0 Val70.A, Ile73.A, Leu74.A, Thr77.A, Val78.A, Ile81.A, Trp398.A, Tyr404.A, Phe441.D
I -12.9 Gln495.B, Tyr499.B, Met508.B, Leu418.C, Leu422.C, Val425.C, Met426.C, Cys429.C, Ser461.C
J -12.7 Lys62.A, Cys64.A, Met67.A, Leu68.A, Val71.A, Val75.A, Phe301.A, Val304.A
K -12.7 Phe441.C, Val70.D, Ile73.D, Leu74.D, Thr77.D, Val78.D, Ile81.D, Trp398.D, Tyr404.D
L -12.3 Lys62.D, Cys64.D, Met67.D, Leu68.D, Val71.D, Val75.D, Phe301.D, Val304.D
M -13.4 Leu492.A, Phe493.A, Leu496.A, Gly353.B, Ile356.B, Leu357.B, Thr360.B, Ile388.B, Thr392.B, Leu396.B, Arg419.B
N -13.0 Gln495.A, Tyr499.A, Met508.A, Leu418.B, Leu422.B, Val425.B, Met426.B, Cys429.B, Ser461.B
O -13.0 Phe441.B, Val70.C, Ile73.C, Leu74.C, Thr77.C, Val78.C, Ile81.C, Trp398.C, Tyr404.C
P -12.9 Leu418.A, Leu422.A, Val425.A, Met426.A, Cys429.A, Ser461.A, Gln495.D, Leu496.D, Tyr499.D, Met508.D
Q -12.8 Phe441.A, Val70.B, Ile73.B, Leu74.B, Thr77.B, Val78.B, Ile81.B, Trp398.B, Tyr404.B
R -12.7 Lys62.B, Cys64.B, Met67.B, Leu68.B, Val71.B, Val75.B, Phe301.B, Val304.B
S -12.4 Lys62.C, Cys64.C, Met67.C, Leu68.C, Val71.C, Val75.C, Phe301.C, Val304.C
TRPML1, closed, Mouse 5wpq
5wpq_EC [none]
5wpq_IC E -14.1 Phe493.C, Gly353.D, Trp354.D, Ile356.D, Leu357.D, Thr360.D, Ile388.D, Thr392.D, Leu396.D
F -14.1 Phe493.B, Gly353.C, Trp354.C, Ile356.C, Leu357.C, Thr360.C, Ile388.C, Thr392.C, Leu396.C
G -14.0 Phe493.A, Gly353.B, Trp354.B, Ile356.B, Leu357.B, Thr360.B, Ile388.B, Thr392.B, Leu396.B
H -13.2 Lys62.C, Pro63.C, Cys64.C, Met67.C, Leu68.C, Val71.C, Val303.C, Val304.C, Leu307.C, Thr308.C
I -13.2 Lys62.D, Cys64.D, Met67.D, Leu68.D, Val71.D, Val303.D, Val304.D, Leu307.D, Thr308.D
J -12.7 Val70.D, Ile73.D, Leu74.D, Val78.D, Ile81.D, Trp398.D, Val401.D, Tyr404.D, Leu405.D
K -12.3 Val70.C, Ile73.C, Leu74.C, Thr77.C, Val78.C, Ile81.C, Trp398.C, Val401.C, Tyr404.C, Leu405.C
L -14.0 Gly353.A, Trp354.A, Ile356.A, Leu357.A, Thr360.A, Ile388.A, Thr392.A, Leu396.A, Phe493.D
M -13.2 Lys62.A, Cys64.A, Met67.A, Leu68.A, Val71.A, Val303.A, Val304.A, Leu307.A, Thr308.A
N -13.2 Lys62.B, Pro63.B, Cys64.B, Met67.B, Leu68.B, Val71.B, Val303.B, Val304.B, Leu307.B, Thr308.B
O -12.6 Val70.A, Ile73.A, Leu74.A, Val78.A, Ile81.A, Trp398.A, Val401.A, Tyr404.A, Leu405.A
P -12.6 Val70.B, Ile73.B, Leu74.B, Val78.B, Ile81.B, Trp398.B, Val401.B, Tyr404.B, Leu405.B
TRPML1, closed, Mouse 5wpt
5wpt_EC [none]
5wpt_IC E -13.4 Tyr439.C, Phe493.C, Leu496.C, Tyr497.C, Gly353.D, Trp354.D, Leu357.D, Leu395.D, Leu396.D, Val399.D
F -13.3 Tyr439.A, Phe493.A, Leu496.A, Tyr497.A, Gly353.B, Leu357.B, Leu395.B, Leu396.B, Val399.B
G -13.3 Tyr439.B, Phe493.B, Leu496.B, Tyr497.B, Gly353.C, Trp354.C, Leu357.C, Leu395.C, Leu396.C, Val399.C
H -13.4 Gly353.A, Leu357.A, Leu395.A, Leu396.A, Val399.A, Tyr439.D, Phe493.D, Leu496.D, Tyr497.D
I -12.9 Ile356.C, Leu357.C, Thr360.C, Leu364.C, Ile388.C, Leu389.C, Thr392.C, Leu396.C
J -12.8 Gln495.C, Leu496.C, Tyr499.C, Ser500.C, Leu504.C, Met508.C, Leu422.D, Met426.D
K -12.7 Ile356.B, Leu357.B, Thr360.B, Leu364.B, Ile388.B, Leu389.B, Thr392.B, Leu396.B
L -12.3 Phe441.B, Val70.C, Ile73.C, Leu74.C, Thr77.C, Val78.C, Ile81.C, Trp398.C, Tyr404.C
M -12.5 Val70.B, Leu74.B, Thr77.B, Val78.B, Ile81.B, Trp398.B, Tyr404.B, Leu405.B, Phe407.B
N -12.6 Ile356.A, Leu357.A, Thr360.A, Leu364.A, Ile388.A, Leu389.A, Thr392.A, Leu396.A
O -12.6 Val70.A, Ile73.A, Leu74.A, Thr77.A, Val78.A, Ile81.A, Trp398.A, Tyr404.A, Leu405.A
TRPML1, closed, Mouse, 5wpv
5wpv_EC [none]
5wpv_IC E -14.4 Arg427.A, Cys430.A, Val434.A, Leu74.B, Thr77.B, Trp398.B, Val401.B, Leu405.B, Phe408.B, Tyr411.B
F -14.2 Leu74.A, Thr77.A, Trp398.A, Val401.A, Leu405.A, Phe408.A, Tyr411.A, Arg427.D, Cys430.D, Val434.D
G -14.5 Arg427.C, Cys430.C, Val434.C, Leu74.D, Thr77.D, Trp398.D, Val401.D, Leu405.D, Phe408.D, Tyr411.D
H -14.4 Arg427.B, Cys430.B, Val434.B, Leu74.C, Thr77.C, Trp398.C, Val401.C, Leu405.C, Phe408.C, Tyr411.C
TRPML1, closed, plus PtdIns(3,5)P2, Human 6e7p
6e7p_EC E -13.6 Phe441.A, Ser456.A, Leu457.A, Ser458.A, Ile73.B, Ile81.B, Trp398.B, Gln484.D, Trp491.D
F -13.6 Ile73.A, Ile81.A, Trp398.A, Gln484.C, Trp491.C, Phe441.D, Ser456.D, Leu457.D, Ser458.D
G -13.0 Ala433.A, Tyr436.A, Leu437.A, Leu457.A, Ser458.A, Ser461.A, Gln484.D, Trp491.D, Tyr499.D
H -12.9 Gln484.C, Trp491.C, Tyr499.C, Cys429.D, Ala433.D, Tyr436.D, Leu437.D, Leu457.D, Ser458.D, Ser461.D
I -13.5 Gln484.A, Trp491.A, Phe441.B, Ser456.B, Leu457.B, Ser458.B, Ile73.C, Ile81.C, Trp398.C
J -13.5 Gln484.B, Trp491.B, Phe441.C, Ser456.C, Leu457.C, Ser458.C, Ile73.D, Ile81.D, Trp398.D
K -13.0 Gln484.B, Trp491.B, Tyr499.B, Cys429.C, Ala433.C, Tyr436.C, Leu437.C, Leu457.C, Ser458.C, Ser461.C
6e7p_IC E -14.4 Tyr439.C, Phe493.C, Leu496.C, Tyr497.C, Ser500.C, Leu504.C, Thr392.D, Leu395.D, Leu396.D, Val399.D, Ile415.D, Leu418.D, Arg419.D, Leu422.D
F -14.4 Thr392.A, Leu395.A, Val399.A, Ile402.A, Ile415.A, Leu418.A, Arg419.A, Leu422.A, Ile435.D, Tyr439.D, Phe493.D, Leu496.D, Tyr497.D, Leu504.D
G -14.3 Tyr439.A, Phe493.A, Leu496.A, Tyr497.A, Ser500.A, Leu504.A, Thr392.B, Leu395.B, Leu396.B, Val399.B, Ile402.B, Ile415.B, Leu418.B, Leu422.B
H -13.5 Phe313.D, Ala317.D, Arg318.D, Leu320.D, Leu321.D, Ile356.D, Val359.D, Val363.D
I -13.1 Cys430.A, Ile73.B, Leu74.B, Thr77.B, Val78.B, Trp398.B, Val401.B, Leu405.B, Phe408.B, Tyr411.B
J -13.0 Phe493.A, Gly353.B, Ile356.B, Leu357.B, Thr360.B, Ile388.B, Thr392.B, Leu396.B
K -13.0 Gly353.A, Ile356.A, Leu357.A, Thr360.A, Ile388.A, Thr392.A, Leu396.A, Phe493.D
L -12.9 Phe493.C, Gly353.D, Trp354.D, Ile356.D, Leu357.D, Thr360.D, Ile388.D, Thr392.D, Leu396.D
M -12.8 Ile73.A, Leu74.A, Thr77.A, Val78.A, Ile81.A, Trp398.A, Val401.A, Tyr404.A, Leu405.A, Phe408.A, Tyr411.A, Cys430.D
N -12.4 Met426.A, Arg427.A, Cys430.A, Ala433.A, Tyr436.A, Leu437.A, Ser461.A, Tyr411.B, Tyr499.D
O -13.3 Phe313.B, Ala317.B, Arg318.B, Leu320.B, Leu321.B, Ile356.B, Val359.B, Val363.B
P -13.3 Tyr499.B, Met426.C, Arg427.C, Cys429.C, Cys430.C, Ala433.C, Tyr436.C, Leu437.C, Ser461.C, Tyr411.D
Q -14.4 Tyr439.B, Phe493.B, Leu496.B, Tyr497.B, Ser500.B, Leu504.B, Thr392.C, Leu395.C, Leu396.C, Val399.C, Ile415.C, Leu418.C, Leu422.C
R -13.5 Phe313.C, Ala317.C, Arg318.C, Leu320.C, Leu321.C, Ile356.C, Val359.C, Val363.C
S -13.2 Val70.C, Ile73.C, Leu74.C, Trp398.C, Val401.C, Tyr404.C, Leu405.C, Phe408.C, Tyr411.C
T -13.0 Phe493.B, Gly353.C, Trp354.C, Ile356.C, Leu357.C, Thr360.C, Ile388.C, Thr392.C, Leu396.C
U -13.0 Cys430.C, Val434.C, Thr77.D, Trp398.D, Val401.D, Leu405.D, Phe408.D, Tyr411.D
V -12.5 Tyr499.A, Met426.B, Arg427.B, Cys430.B, Ala433.B, Leu437.B, Ser461.B, Tyr411.C
TRPML1, closed, plus PtdIns(4,5)P2, Human 6e7y
6e7y_EC [none]
6e7y_IC E -14.2 Leu357.A, Thr360.A, Leu364.A, Ile388.A, Leu389.A, Thr392.A, Leu396.A, Arg419.A
F -13.5 Pro63.B, Cys64.B, Met67.B, Leu68.B, Val71.B, Phe301.B, Val304.B, Thr308.B
G -14.0 Leu492.A, Phe493.A, Leu496.A, Leu357.B, Ile388.B, Thr392.B, Leu396.B, Arg419.B
H -13.5 Pro63.A, Cys64.A, Met67.A, Leu68.A, Val71.A, Phe301.A, Val304.A, Thr308.A
I -13.7 Pro63.C, Cys64.C, Lys65.C, Leu66.C, Met67.C, Leu68.C, Val71.C, Leu300.C, Val304.C, Thr308.C
J -13.6 Phe493.C, Gly353.D, Ile356.D, Leu357.D, Thr360.D, Leu364.D, Ile388.D, Thr392.D, Leu396.D
K -13.5 Phe493.B, Gly353.C, Ile356.C, Leu357.C, Thr360.C, Ile388.C, Thr392.C, Leu396.C
L -13.7 Pro63.D, Cys64.D, Lys65.D, Leu66.D, Met67.D, Leu68.D, Val71.D, Leu300.D, Val304.D, Thr308.D
TRPML1, open, plus PtdIns(3,5)P2 and agonist  ML-SA1, Human 6e7z
6e7z_EC E -12.4 Phe441.B, Ile73.C, Leu74.C, Thr77.C, Val78.C, Ile81.C, Leu82.C, Leu85.C, Trp398.C
F -12.4 Phe441.C, Leu74.D, Thr77.D, Val78.D, Ile81.D, Leu82.D, Leu85.D, Trp398.D
G -12.4 Phe441.A, Ile73.B, Leu74.B, Thr77.B, Val78.B, Ile81.B, Leu82.B, Leu85.B, Trp398.B
H -12.3 Leu74.A, Thr77.A, Val78.A, Ile81.A, Leu82.A, Leu85.A, Trp398.A, Phe441.D
6e7z_IC E -13.6 Val434.C, Leu437.C, Phe441.C, Val70.D, Ile73.D, Trp398.D, Val401.D, Tyr404.D, Leu405.D
F -13.6 Cys430.B, Val434.B, Leu437.B, Phe441.B, Leu74.C, Thr77.C, Trp398.C, Leu405.C, Tyr411.C
G -13.0 Phe493.B, Leu496.B, Trp354.C, Leu357.C, Thr392.C, Leu395.C, Leu396.C, Val399.C
H -13.0 Phe493.A, Leu496.A, Trp354.B, Leu357.B, Thr392.B, Leu395.B, Leu396.B, Val399.B, Leu418.B
I -13.2 Trp354.A, Ile356.A, Leu357.A, Thr360.A, Leu364.A, Ile388.A, Thr392.A, Leu396.A
J -14.2 Val70.B, Ile73.B, Leu74.B, Thr77.B, Trp398.B, Val401.B, Tyr404.B, Leu405.B
K -13.4 Tyr439.C, Phe493.C, Leu496.C, Tyr497.C, Ser500.C, Leu504.C, Trp354.D, Thr392.D, Leu395.D, Leu396.D, Val399.D, Ile402.D, Ile415.D, Leu418.D
L -13.4 Leu74.A, Thr77.A, Trp398.A, Leu405.A, Tyr411.A, Cys430.D, Val434.D, Leu437.D, Phe441.D
TRPML3
TRPML3, closed, with CHS and PE, Marmoset 5w3s
5w3s_EC E -13.9 Trp475.C, Tyr483.C, Ala420.D, Tyr423.D, Leu424.D, Leu444.D, Asn445.D, Ser448.D
F -13.9 Trp475.A, Tyr483.A, Ala420.C, Tyr423.C, Leu424.C, Leu444.C, Asn445.C, Ser448.C
G -13.9 Ala420.A, Tyr423.A, Leu424.A, Leu444.A, Asn445.A, Ser448.A, Trp475.B, Tyr483.B
H -13.2 Phe428.C, Leu444.C, Ile70.D, Ala71.D, Thr74.D, Val78.D, Leu82.D, Trp385.D
I -12.8 Ile70.B, Ala71.B, Thr74.B, Val78.B, Leu82.B, Trp385.B, Phe428.D, Leu444.D
J -13.2 Ile67.C, Leu68.C, Ala71.C, Met72.C, Ile75.C, Leu79.C, Asn284.C, Phe288.C
K -13.3 Phe428.A, Leu444.A, Ile70.C, Ala71.C, Thr74.C, Val78.C, Leu82.C, Trp385.C
L -13.2 Ile70.A, Ala71.A, Thr74.A, Val78.A, Leu82.A, Trp385.A, Phe428.B, Leu444.B
5w3s_IC E -15.5 Phe477.C, Gly340.D, Trp341.D, Met344.D, Ile347.D, Thr379.D, Leu383.D, Leu386.D, Gln406.D
F -15.4 Gly340.C, Trp341.C, Met344.C, Ile347.C, Thr379.C, Leu383.C, Leu386.C, Gln406.C
G -13.3 Met421.C, Phe428.C, Cys50.D, Ile67.D, Ile70.D, Ala71.D, Thr74.D, Trp385.D, Val388.D, Tyr391.D, Leu392.D, Phe394.D
H -13.2 Met421.A, Phe428.A, Cys50.C, Ile67.C, Ile70.C, Ala71.C, Thr74.C, Trp385.C, Val388.C, Tyr391.C, Leu392.C
I -13.2 Cys50.B, Ile67.B, Ile70.B, Ala71.B, Thr74.B, Trp385.B, Val388.B, Tyr391.B, Leu392.B, Met421.D, Phe428.D
J -12.8 Trp385.B, Leu392.B, Phe395.B, Tyr398.B, Cys417.D, Met421.D, Leu424.D, Phe428.D
K -12.8 Cys417.C, Met421.C, Leu424.C, Phe428.C, Trp385.D, Leu392.D, Phe395.D, Tyr398.D
L -15.5 Gly340.A, Trp341.A, Met344.A, Ile347.A, Thr379.A, Leu383.A, Leu386.A, Gln406.A
M -15.4 Gly340.B, Trp341.B, Met344.B, Ile347.B, Thr379.B, Leu383.B, Leu386.B, Gln406.B
N -13.2 Cys50.A, Ile67.A, Ile70.A, Ala71.A, Thr74.A, Trp385.A, Val388.A, Tyr391.A, Leu392.A, Phe394.A, Phe395.A, Met421.B, Phe428.B
O -12.8 Trp385.A, Leu392.A, Phe395.A, Tyr398.A, Cys417.B, Met421.B, Leu424.B, Phe428.B
P -12.8 Cys417.A, Met421.A, Leu424.A, Phe428.A, Trp385.C, Leu392.C, Phe395.C, Tyr398.C
TRPML3, open, with agonist ML-SA1, Human 6ayf
6ayf_EC E -13.3 Ala420.B, Tyr423.B, Leu424.B, Cys427.B, Ser443.B, Leu444.B, Asn445.B, Ser448.B, Tyr472.C, Trp475.C, Tyr483.C
F -13.2 Trp475.A, Tyr483.A, Tyr423.D, Leu424.D, Cys427.D, Ser443.D, Leu444.D, Asn445.D, Ser448.D
G -13.1 Ala420.C, Tyr423.C, Leu424.C, Cys427.C, Leu444.C, Asn445.C, Ser448.C, Tyr472.D, Trp475.D, Tyr483.D
H -12.7 Phe428.A, Trp431.A, Ser443.A, Leu444.A, Asn445.A, Ala71.D, Val78.D, Leu82.D, Trp385.D
I -12.7 Ala71.A, Val78.A, Leu82.A, Gln85.A, Trp385.A, Phe428.B, Trp431.B, Ser443.B, Leu444.B, Asn445.B
J -13.4 Ile70.B, Ala71.B, Thr74.B, Val78.B, Leu82.B, Trp385.B, Phe428.C, Leu444.C
K -13.3 Ala420.A, Tyr423.A, Leu424.A, Cys427.A, Ser443.A, Leu444.A, Asn445.A, Ser448.A, Tyr472.B, Trp475.B, Tyr483.B
L -13.0 Ile70.C, Ala71.C, Thr74.C, Val78.C, Leu82.C, Trp385.C, Phe428.D, Leu444.D
6ayf_IC E -14.0 Glu51.A, Leu63.A, Ile67.A, Ile70.A, Ala71.A, Thr74.A, Ile75.A, Trp385.A, Val388.A, Tyr391.A, Leu392.A, Phe394.A, Phe395.A
F -14.0 Leu63.B, Ile67.B, Ile70.B, Ala71.B, Thr74.B, Ile75.B, Trp385.B, Val388.B, Tyr391.B, Leu392.B, Phe394.B, Phe395.B
G -14.0 Leu63.C, Ile67.C, Ile70.C, Ala71.C, Thr74.C, Ile75.C, Trp385.C, Val388.C, Tyr391.C, Leu392.C, Phe394.C, Phe395.C
H -13.4 Trp341.B, Met344.B, Met382.B, Leu383.B, Leu386.B, Ile402.B, Leu405.B, Gln406.B, Ile422.C, Phe477.C, Ile480.C, Tyr481.C, Ser484.C, Leu488.C
I -13.3 Trp341.C, Met344.C, Met382.C, Leu383.C, Leu386.C, Ile402.C, Leu405.C, Gln406.C, Ile422.D, Phe477.D, Ile480.D, Tyr481.D, Leu488.D
J -14.0 Leu63.D, Ile67.D, Ile70.D, Ala71.D, Thr74.D, Ile75.D, Trp385.D, Val388.D, Tyr391.D, Leu392.D, Phe394.D, Phe395.D
K -13.5 Ile422.A, Phe477.A, Ile480.A, Tyr481.A, Leu488.A, Trp341.D, Met344.D, Met382.D, Leu383.D, Leu386.D, Ile402.D, Leu405.D, Gln406.D
L -13.5 Trp341.A, Met344.A, Met382.A, Leu383.A, Leu386.A, Ile402.A, Leu405.A, Gln406.A, Phe477.B, Ile480.B, Tyr481.B, Ser484.B, Leu488.B
TRPN
TRPN (NOMPC), closed, with PC, Drosophila 5vkq
5vkq_EC E -12.8 Phe1452.A, Met1456.A, Phe1486.A, Val1489.A, His1492.A, Pro1493.A, Ile1312.D, Met1315.D, Ile1316.D, Ser1319.D, Thr1324.D, Phe1409.D
F -12.6 Ile1279.C, Ile1312.C, Met1315.C, Ile1316.C, Ser1319.C, Thr1324.C, Phe1452.D, Met1456.D, Phe1486.D, His1492.D, Pro1493.D
G -12.4 Tyr1337.D, Trp1338.D, Val1341.D, Gly1342.D, Ile1345.D, Trp1346.D, Pro1592.D, Leu1593.D, Val1596.D
H -12.4 Trp1338.C, Val1341.C, Gly1342.C, Ile1345.C, Trp1346.C, Pro1592.C, Leu1593.C, Val1596.C
I -12.3 Leu1373.A, Ala1377.A, Gly1380.A, Val1381.A, Ser1384.A, Phe1388.A, Ser1390.A, Lys1391.A, Leu1397.A
J -12.4 Trp1338.A, Val1341.A, Gly1342.A, Ile1345.A, Trp1346.A, Pro1592.A, Leu1593.A, Leu1595.A, Val1596.A
K -12.7 Leu1373.D, Ala1377.D, Gly1380.D, Val1381.D, Ser1384.D, Phe1388.D, Ser1390.D, Lys1391.D, Leu1397.D
L -13.0 Ile1312.B, Met1315.B, Ser1319.B, Thr1324.B, Phe1452.C, Met1456.C, Phe1486.C, His1492.C, Pro1493.C
M -12.8 Ile1312.A, Met1315.A, Ile1316.A, Ser1319.A, Thr1324.A, Phe1409.A, Phe1452.B, Met1456.B, Phe1486.B, Val1489.B, His1492.B, Pro1493.B
N -12.6 Leu1373.C, Leu1374.C, Ala1377.C, Val1381.C, Ser1384.C, Phe1388.C, Lys1391.C, Leu1397.C
O -12.3 Trp1338.B, Val1341.B, Gly1342.B, Ile1345.B, Trp1346.B, Pro1592.B, Leu1593.B, Leu1595.B, Val1596.B
P -12.5 Leu1373.B, Leu1374.B, Ala1377.B, Val1381.B, Ser1384.B, Phe1388.B, Lys1391.B, Leu1397.B
5vkq_IC E -14.1 Leu1275.C, Ile1279.C, Phe1304.C, Leu1308.C, Ile1312.C, Met1315.C, Ile1316.C, Ile1416.C, Phe1419.C, Leu1420.C, Phe1422.C, Phe1452.D
F -14.0 Phe1452.A, Leu1275.D, Phe1304.D, Leu1308.D, Ile1312.D, Met1315.D, Ile1416.D, Phe1419.D, Leu1420.D, Phe1422.D
G -13.9 Leu1533.A, Ile1536.A, Val1537.A, Ile1540.A, Gly1363.D, Leu1364.D, Ser1366.D, Ile1367.D, Leu1370.D, Leu1407.D, Leu1411.D, Val1414.D, Leu1437.D
H -13.6 Gly1363.A, Leu1364.A, Ser1366.A, Ile1367.A, Leu1370.A, Leu1407.A, Leu1411.A, Val1414.A, Leu1437.A, Leu1533.B, Ile1536.B, Val1537.B, Ile1540.B
I -13.2 Leu1437.A, Lys1438.A, Leu1440.A, Ala1441.A, Leu1444.A, Phe1497.A, Ile1536.B, Ile1540.B, Leu1543.B
J -14.1 Leu1275.A, Phe1304.A, Leu1308.A, Ile1312.A, Met1315.A, Ile1416.A, Phe1419.A, Leu1420.A, Phe1422.A, Phe1452.B
K -14.7 Ala1445.A, Ala1448.A, Ile1449.A, Phe1452.A, Ile1494.A, Phe1497.A, Leu1420.D, His1423.D, Leu1425.D, Phe1426.D
L -13.6 Leu1420.C, Leu1425.C, Ala1441.D, Ala1445.D, Ala1448.D, Phe1452.D, Ile1494.D, Phe1497.D
M -13.5 Ile1536.A, Ile1540.A, Leu1543.A, Leu1437.D, Leu1440.D, Ala1441.D, Leu1444.D, Phe1497.D, Glu1498.D, Phe1501.D
N -13.6 Leu1437.C, Leu1440.C, Ala1441.C, Leu1444.C, Phe1497.C, Glu1498.C, Phe1501.C, Ile1536.D, Ile1540.D, Leu1543.D
O -14.1 Gly1363.C, Leu1364.C, Ser1366.C, Ile1367.C, Leu1370.C, Leu1407.C, Leu1411.C, Val1414.C, Leu1437.C, Ile1536.D, Val1537.D, Ile1540.D
P -13.7 Gly1363.B, Leu1364.B, Ser1366.B, Ile1367.B, Leu1370.B, Leu1407.B, Leu1411.B, Val1414.B, Leu1437.B, Leu1533.C, Ile1536.C, Val1537.C, Ile1540.C
Q -13.2 Leu1275.B, Ile1279.B, Phe1304.B, Leu1308.B, Ile1312.B, Met1315.B, Ile1316.B, Ser1319.B, Ile1416.B, Phe1419.B, Leu1420.B, Phe1422.B, Phe1452.C
R -13.0 Leu1437.B, Leu1440.B, Ala1441.B, Leu1444.B, Phe1497.B, Glu1498.B, Phe1501.B, Lys1535.C, Ile1536.C, Gly1539.C, Ile1540.C, Leu1543.C
S -14.2 Leu1420.A, Leu1425.A, Ala1445.B, Ala1448.B, Ile1449.B, Phe1452.B, Ile1494.B, Phe1497.B
T -13.6 Leu1420.B, His1423.B, Leu1425.B, Phe1426.B, Ala1441.C, Ala1445.C, Ala1448.C, Phe1452.C, Ile1494.C, Phe1497.C